Paget's disease of the male breast clinically and histopathologically mimicking melanoma

Stretch, Jonathan R.; Denton, Karin; Millard, P.R.; Horak, E.

doi:10.1111/j.1365-2559.1991.tb00240.x

Cited by 25 publications

(19 citation statements)

References 6 publications

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“…It was first reported in 1990 by Ho et al 3 , and only a few such cases have been described afterwards [1][2][3][4][5][6][7][8][9][10][11] . It has been described as hyperpigmented patches or plaques involving the areola and nipple, which may simulate melanoma both clinically and histopathologically.…”

Section: Discussionmentioning

confidence: 99%

“…The local production of melanocytic chemotactic factor by breast cancer cells and pigment blockade of the melanocytes have been postulated as the cause for the clinical pigmentation in some cases of mammary Paget's disease 16 . Dusty melanin has also been described within the cytoplasm of the neoplastic cells of mammary Paget's disease, without an increased number of melanocytes 3,4 . Another possibility would be phagocytosis of the melanin pigment from the melanocytes by the epithelial cells of the carcinoma 17 .…”

Section: Discussionmentioning

confidence: 99%

“…The characteristic pigmentation is mostly due to the presence of dispersed melanocytes within the tumor and melanophages in the stroma 2 . Only a few such cases have been described after the first reported case of pigmented mammary Paget's disease in 1990 [1][2][3][4][5][6][7][8][9][10][11] . Herein, we report on a rare case of pigmented mammary Paget's disease.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Pigmented Mammary Paget's Disease

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Case of Pigmented Mammary Paget's Disease

et al. 2008

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“…Out of the cases reported only nine cases were presented as the pigmented variant of mammary Paget's disease [7,8,12,16,[19][20][21][22][23] . All reported cases of PMPD in men were associated with an underlying breast carcinoma but one (Bernadi et al).…”

Section: Case Presentationmentioning

confidence: 99%

Pigmented mammary paget’s disease mimicking melanoma in male patients: a case report and review of the literature

Rencüzoğulları

Okoh

Yalav

et al. 2015

CRCP

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Background: Pigmented mammary Paget's disease (PMPD) of the male breast is extremely rare, and only few cases have been reported to date. Due to the scarcity of the disease, diagnosis as well as treatment is usually delayed. Men tend to present with earlier symptoms, nevertheless, prognosis is known to be worse, with only 20% to 30% of the patients surviving over a five year period. Methods:A case report of a 47-year-old male who presented with a chronic pigmented lesion on the nipple that was later on diagnosed as PMPD.Results: Microscopic pathological evaluation of mastectomy specimen of the nipple revealed invasive ductal carcinoma Grade II and in situ ductal carcinoma. Estrogen and progesterone receptors were 95% and 80% positive for tumor cells. Atypical cells stained positivite for anticytokeratin 7, c-erbB-2, and CEA on immunohistochemistry while cytoplasmic dusty melanin pigments stained focally positive for S-100 and HMB-45.Conclusion: Although being a rare entity; PMPD should always be kept in mind as a differential diagnosis in melanocytic lesions of the nipple. Histopathology including immunohistochemical staining should always be performed for the correct diagnosis and management.

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“…Paget’s disease is an intraductal carcinoma of the breast with spread into the epidermis of the nipple and areola [1, 2, 3, 4, 5, 6, 7]. Most patients with Paget’s disease are females, and only 1–5% of mammary carcinomas occur in males [3, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

Pigmented Paget’s Disease of the Male Breast: Report of a Case

et al. 2001

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An 83-year-old man with pigmented Paget’s disease of the breast is reported. He had a blackish swollen right nipple with bloody discharge that lasted for 8 months. Histopathology of the lesion disclosed intraepidermal and dermal atypical cells forming small clusters and underlying intraductal carcinoma. Melanocytes were dispersed in the epidermis. Dermal melanophages were also detected. The atypical cells were positive for carcinoembryonic antigen, human-milk fat globule protein and a recently described new antigen, RCAS-1, but negative for S-100 or HMB-45. We diagnosed this case as Paget’s disease of the male breast. Paget’s disease of the breast is usually nonpigmented and occurs almost exclusively in women. Pigmented Paget’s disease of the male breast is extremely rare, and only a few cases have been reported. Albeit rare, pigmented Paget’s disease has to be included in the differential diagnosis of pigmented lesions of the nipple.

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Paget's disease of the male breast clinically and histopathologically mimicking melanoma

Cited by 25 publications

References 6 publications

A Case of Pigmented Mammary Paget's Disease

A Case of Pigmented Mammary Paget's Disease

Pigmented mammary paget’s disease mimicking melanoma in male patients: a case report and review of the literature

Pigmented Paget’s Disease of the Male Breast: Report of a Case

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