Paget's disease of the esophagus

Karakök, Metin; Aydın, Abdullah; Sarı, İbrahim; Koruk, Mehmet; Savaş, Merve; Kadayıfçı, Abdurrahman

doi:10.1046/j.1442-2050.2002.00266.x

Cited by 8 publications

(5 citation statements)

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“…According to several reports of primary esophageal Paget's disease, the patients' main complaints were dysphagia or chest discomfort similar to reflux esophagitis [2]. As Paget's cancer cells grow extensively superficially and multifocally into the mucosal and submucosal ducts without any protruded lesions, it is not so easy to diagnose this rare disease [3]. Endoscopic Lugol iodine spraying (Lugol chromoendoscopy) identifies Lugol-voiding lesions (LVLs), suggesting malignancy.…”

Section: Discussionmentioning

confidence: 99%

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Rare Primary Esophageal Paget’s Disease Diagnosed on a Large Bloc Specimen Obtained by Endoscopic Mucosal Resection

Mori

Ayaki

Kobara

et al. 2017

JGLD

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Primary esophageal Paget's disease is rare. Only a few case reports have described the intraepithelial papillary capillary loop (IPCL) pattern obtained by magnified Narrow Band Imaging (M-NBI) endoscopy in this rare pathology. This report highlights the usefulness of M-NBI and the successful diagnosis using a large bloc specimen obtained by endoscopic mucosal resection with the cap method (EMR-c). A 53-year-old man was referred to endoscopic examination for dysphagia. The endoscopic image revealed a ring-shaped scarring of the esophagus suggestive for eosinophilic esophagitis. The IPCL pattern by M-NBI endoscopy showed an inflammatory pattern, and the entire epithelium of the esophagus was not stained by Lugol iodine spraying. Based on six biopsies randomly performed, a poorly differentiated adenocarcinoma was diagnosed. Since the M-NBI pattern and the histology were completely different, EMR-c was performed to obtain large bloc specimens for a more detailed diagnosis. The pathological findings revealed extensive Paget's cells infiltration into the epithelium and multifocal invasion from the mucosa to the submucosal layer with adenocarcinoma. In conclusion, a large bloc specimen by EMR-c might be more useful than a small biopsy for an accurate diagnosis of the rare esophageal Paget's disease.

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Section: Discussionmentioning

confidence: 99%

“…Conventional Lugol chromoendoscopy is used to diagnose the malignant potential lesion of the esophagus. This technique has some limitations for the correct assessment of Lugol-voiding lesions (LVLs) [3]. Magnified Narrow Band Imaging (M-NBI) endoscopy might be used for a better characterization of LVLs [4].…”

Section: Introductionmentioning

confidence: 99%

Rare Primary Esophageal Paget’s Disease Diagnosed on a Large Bloc Specimen Obtained by Endoscopic Mucosal Resection

Mori

Ayaki

Kobara

et al. 2017

JGLD

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“…Background: Paget’s disease is thought to be a peculiar type of epidermotropic adenocarcinoma of mammary and extramammary tissues[ 80 ]. Extramammary Paget’s disease is most commonly seen in the vulva and anus, while an oesophageal location is exceedingly rare, with less than ten cases described[ 81 , 82 ]. Oesophageal Paget’s disease (OPD) always arises in the setting of Barrett’s oesophagus[ 81 , 82 ].…”

Section: Rare Primitive Oesophageal Malignant Tumours Of Epithelial Omentioning

confidence: 99%

“…Clinical features and diagnostic approach: Typically, patients complain of progressive dysphagia, eventually accompanied by chest discomfort similar to reflux oesophagitis[ 81 , 82 ]. EGDS is a first-line diagnostic tool.…”

Section: Rare Primitive Oesophageal Malignant Tumours Of Epithelial Omentioning

confidence: 99%

Histopathological landscape of rare oesophageal neoplasms

Businello

Pozzo

Sbaraglia

et al. 2020

WJG

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The landscape of neoplastic pathology of the oesophagus is dominated by malignancies of epithelial origin, in particular by oesophageal adenocarcinoma and oesophageal squamous cell carcinoma. However, several other histopathological variants can be distinguished, some associated with peculiar histopathological profiles and prognostic behaviours and frequently underrecognized in clinical practice. The aim of this review is to provide a comprehensive characterization of the main morphological and clinical features of these rare variants of oesophageal neoplastic lesions.

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“…Having been first described in the breast by Sir James Paget in 1874, extramammary Paget’s disease is an entity most commonly seen in the vulva and anus but it is known to occur rarely in the esophagus, almost exclusively in the context of invasive esophageal adenocarcinoma. Paget’s cells within esophageal squamous epithelium are found in 4.9% of invasive adenocarcinoma cases and are most commonly associated with diffuse, poorly differentiated adenocarcinoma with dyscohesive malignant cells [2–5]. Few case reports are present in the literature to describe Paget’s cells within the esophagus but those that exist include cases involving mucous gland carcinoma, adenosquamous carcinoma and adenocarcinoma arising on a background of Barrett’s esophagus [2–5].…”

Section: Introductionmentioning

confidence: 99%