Paget’s disease of the axilla arising from an underlying accessory mammary tissue

Khoury, Mona El; Lalonde, Lucie; David, Julie; Issa-Chergui, Badia; Péloquin, L.; Trop, Isabelle

doi:10.1016/j.crad.2010.12.010

Cited by 10 publications

(11 citation statements)

References 10 publications

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“…However, the location was far from the normal milk line along which ectopic nipples usually occur and a previously existing nipple was not observed. Extramammary Paget disease is thought to arise from apocrine glands, as it occurs in the genital, perianal, and axillary areas [4,5] . However, the recurrence was far from the axilla and no apocrine glands were present.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of breast carcinoma as Paget disease of the skin at a prior core needle biopsy site: Case report and review of the literature

Calvillo

Guo

Brostrom

et al. 2015

International Journal of Surgery Case Reports

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HighlightsRecurrence of breast cancer at the site of a prior core needle biopsy after definitive surgery is very rare—only 13 cases have been reported.The majority are recurrent invasive cancers forming palpable masses in dermis and subcutaneous tissue at the skin puncture site of the core needle biopsy.Diagnosis can be delayed if a lesion is not initially recognized as being at a needle biopsy site.We report the first case of needle puncture site recurrence as Paget disease of the epidermis (ductal carcinoma in situ).It is important to document the site of the skin puncture of a needle biopsy to aid in early detection, and recognition, of needle track recurrences.

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Section: Discussionmentioning

confidence: 99%

Recurrence of breast carcinoma as Paget disease of the skin at a prior core needle biopsy site: Case report and review of the literature

Calvillo

Guo

Brostrom

et al. 2015

International Journal of Surgery Case Reports

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“…Other rare areas affected by EMPD include the axilla, vulva and even less frequently the external ear canal, truncal skin and eyelids 1,8. Unlike mammary Paget's disease, EMPD is less often associated with an underlying malignancy 9. A recent study showed that only 14% of patients with unilateral axillary EMPD had an underlying carcinoma 10…”

Section: Discussionmentioning

confidence: 99%

Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature

2014

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Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget's cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.

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“…This would cause severe melanogenesis and diffuse pigmentation. An alternative hypothesis is that diffuse melanosis occurs as a result of chemotherapy-induced tumor lysis with the release of melanosomes into the bloodstream [7]. The release of melanosomes, later excreted in the urine, is also a potential explanation for the frequently observed melanuria.…”

Section: Dear Editorsmentioning

confidence: 99%

“…Pigmentation of axillary EMP lesions is very rare; in such instances, the lesions must be differentiated from melanoma and Bowen disease [5]. Another very rare type of axillary EMP has been reported by Khoury and colleagues who described a solitary lesion in the axilla which was associated with an underlying ductal carcinoma in situ of the breast, and had formed in ectopic mammary tissue of the axilla [7]. There are various therapeutic approaches to EMP.…”

Section: Extramammary Paget Disease Involving One Axillamentioning

confidence: 99%

Diffuse melanosis in a patient with multifocal liver and thyroid metastases of a malignant melanoma

Jantke

Schön

Kretschmer

et al. 2012

J Deutsche Derma Gesell

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Paget’s disease of the axilla arising from an underlying accessory mammary tissue

Cited by 10 publications

References 10 publications

Recurrence of breast carcinoma as Paget disease of the skin at a prior core needle biopsy site: Case report and review of the literature

Recurrence of breast carcinoma as Paget disease of the skin at a prior core needle biopsy site: Case report and review of the literature

Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature

Diffuse melanosis in a patient with multifocal liver and thyroid metastases of a malignant melanoma

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