Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features

Giltman, Larry I.; Osborne, Pamela T.; Coleman, Sidney A.; Uthman, Edward '

doi:10.1002/jso.2930280408

Cited by 18 publications

(2 citation statements)

References 9 publications

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“…Kubota et al 6 reviewed 28 cases of perianal Paget's disease associated with anorectal carcinoma. 1,5,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] We found continuity between the primary anal canal carcinoma and the perianal lesion in the epidermis in our patient. The Paget's cells were scattered from the distal surgical margin of the anal canal adenocarcinoma to the epidermis of the perianal skin, forming some glandular structures.…”

Section: Discussionmentioning

confidence: 89%

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

et al. 2006

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A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal. The patient was asymptomatic. The lesion was 14 mm in diameter and located 5 mm from the dentate line. Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal. During transanal local excision of the tumor, an abnormality of the perianal skin was recognized. Although intraoperative frozen section of the perianal skin did not show malignancy, permanent sections of the perineal skin revealed Paget's cells in the epidermis. Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin. Thus, we performed additional wide local excision of the perianal skin including the distal margin of the previous local excision. Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion. Scattered Paget's cells also formed some glandular structures. Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma. This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.

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Section: Discussionmentioning

confidence: 89%

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

et al. 2006

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“…Mucoepidermoid carcinoma of the anal canal, a type of primary malignant tumor, is a rare lesion that is characterized by goblet cell-type mucous cells arranged in solid sheets. To date, only 58 cases have been reported in the literature (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The origin of this tumor is a subject of debate, and its precise histogenesis also remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the anal canal: A case report and review of the literature

Yamamoto¹,

Hirata

Tuneyoshi³

et al. 2018

mol clin onc

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Mucoepidermoid carcinoma of the anal canal is a rare tumor. We herein report the case of a 74-year-old male patient with a high-grade mucoepidermoid carcinoma of the anal canal who was treated by local surgical resection and subsequent irradiation. However, the patient succumbed to liver and lung metastases 2 years after the procedure. The characteristic findings of mucoepidermoid carcinoma of the anus remain unclear to date due to rarity of this tumor. Since 1954, when this type of tumor was first described, only 58 cases of patients diagnosed with mucoepidermoid carcinoma of the anus have been reported to date. In this context, a review of the existing English literature on this rare tumor was also performed.

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Surgical Pathology of the Anal Canal: A Review of Recent Literature on Anatomy and Pathology

Fenger¹

1989

Progress in Surgical Pathology

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Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features

Cited by 18 publications

References 9 publications

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

Anal Canal Carcinoma with Pagetoid Spread: Report of a Case

Mucoepidermoid carcinoma of the anal canal: A case report and review of the literature

Surgical Pathology of the Anal Canal: A Review of Recent Literature on Anatomy and Pathology

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