Paget's disease and metastatic carcinoma. A case report

Ja, Roberts

doi:10.1302/0301-620x.68b1.3941136

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the previously published cases that reported coexistence of PDB and metastatic bone disease, the primary sites of malignancy were the breast, lung, and prostate. [18][19][20][21] In our patient, the final diagnosis of metastatic bone disease secondary to adenocarcinoma of the lung was found after PDB was diagnosed by bone biopsy. As illustrated in the case, three modalities, including radiography, bone biopsy and 18 F-FDG PET/CT were utilized in the diagnostic process.…”

Section: Discussionmentioning

confidence: 84%

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Lim

Kok

Kamaruddin

2018

JAFES

View full text Add to dashboard Cite

A 69-year-old female complained of intermittent left hip pain for the past 3 years. Biochemical tests revealed normal serum calcium and phosphorus with markedly raised alkaline phosphatase. MRI of the hip revealed extensive marrow signal abnormalities at the left pelvic bone, while CT of the thorax revealed a spiculated lung nodule at the left lower lung lobe. In order to diagnose either primary, metastatic bone tumour or Paget's disease of the bone (PDB), an open biopsy of the left iliac bone was performed. The histopathology of bone biopsy of the left iliac bone was consistent with PDB. A CT guided biopsy of the lung mass done later revealed adenocarcinoma of the lung. She had 18 F-FDG PET-CECT Scan for staging evaluation and result was suggestive of new bony metastases. Patient was started on IV Zoledronic acid for treatment of the PDB. In view of the stage 4 lung adenocarcinoma with bony metastases, patient was scheduled for palliative chemotherapy.

show abstract

Section: Discussionmentioning

confidence: 84%

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Lim

Kok

Kamaruddin

2018

JAFES

View full text Add to dashboard Cite

show abstract

“…Among the previously published cases, the primary sites of malignancy in patients with Paget's disease were the breast, lung, and prostate. [789]…”

Section: Discussionmentioning

confidence: 99%

“…[8] A 99m Tc MDP bone scan may be useful in differentiating the etiology of low back pain, when diagnosis is questionable. In Paget's disease, the tracer uptake is intense, symmetrical, and well demarcated.…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone

Shetty

Prabhu

et al. 2016

J Family Med Prim Care

View full text Add to dashboard Cite

Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon. We report a case of a 63-year-old man who presented with back pain and a lump in the right breast. He was earlier diagnosed to have Paget's disease of bone based on characteristic skeletal radiological features,99mTc methylene diphosphonate bone scan and elevated alkaline phosphatase, and treated with bisphosphonates, and his disease was in remission. Further evaluation revealed an underlying skeletal metastatic disease secondary to a breast malignancy. He underwent radical mastectomy with axillary node clearance, radiotherapy, and chemotherapy. In addition, he also received parenteral bisphosphonates for his skeletal metastatic bone disease.

show abstract

“…Goldenberg (1961) mentioned a case of metastasis from prostate to Pagetic iliac bone.9 Due to the increased blood supply to the limbs in Paget's disease,'" there may be preferential haematogenous metastasis to the affected bone from a primary site. 8 Paget's disease can be detected much earlier by a bone scan, which may show a monostotic Paget's disease to be a polyostotic disease. Bone scans help not only in diagnosis but also in assessment of the activity of the Pagetic lesion.…”

Section: Discussionmentioning

confidence: 99%

Unilateral sclerosis of upper femur

Kumar

Shoaib

1998

Postgraduate Medical Journal

View full text Add to dashboard Cite

A 75-year-old man, a known patient with diagnosed prostate carcinoma for about 18 months, presented to us in the emergency department with sudden onset, excruciating pain around the right hip and thigh region. He was unable to walk or bear weight on the right side. There was no history of trauma or fever and he had never had similar pain in the past. He was on medical treatment for his prostate carcinoma. On examination he was in obvious discomfort from pain despite having an intramuscular analgesia. All the vital signs were stable. Local examination revealed an increase in skin temperature and tenderness in the upper thigh. Any attempts at palpation or movement aggravated the pain. There was no obvious swelling, abnormal mobility or crepitus. Routine blood investigations (blood counts, urea and electrolytes) were within normal limits. Bone profile was recorded as calcium 2.23 mmol/l (normal range 2.2-2.6), phosphorus 1.08 mmol/l (0.8-1.4), alkaline phosphatase 104 IU/l (40-120) and prostate-specific antigen 4.1 ,ug/l (0.0-4.0). An X-ray of the pelvis is shown in the figure. X-Rays of lumbar spine, chest and skull did not reveal any bony abnormality.

show abstract

Paget's disease and metastatic carcinoma. A case report

Cited by 6 publications

References 0 publications

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

Metastatic Bone Disease Secondary to Bronchial Adenocarcinoma in a Patient with Paget’s Disease of the Bone

An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone

Unilateral sclerosis of upper femur

Contact Info

Product

Resources

About