Paeonol inhibits melanoma growth by targeting PD1 through upregulation of miR-139-5p

Chen, Xianjie; Xu, Zhenyuan; Li, Meng; Ding, Wenyuan; Zhong, Jun; Deng, Suihui; Li, Siyan; Miao, Jifei; Liu, Xiaoyi; Wen, Quan; Ye, Sen; Li, Chun; Li, Hui

doi:10.1016/j.bbrc.2023.03.005

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…The aforementioned mechanisms underscore the potential of Pae in conferring cardio‐protection and promoting vascular regeneration. Moreover, Pae exhibits extensive antitumor properties by modulating the tumor microenvironment through multiple signaling pathways, thereby impeding cancer cell proliferation (Zhou et al, 2020), inducing apoptosis and autophagy in cancer cells (Gao et al, 2019; Saahene et al, 2018), and fostering immune regulation against tumors within the human body (Chen et al, 2023). However, due to its inherent instability and short half‐life, the translation of its antitumor effect into clinical practice remains challenging.…”

Section: Discussion and Further Perspectivementioning

confidence: 99%

Protective mechanism of Paeonol on central nervous system

Wu,

Liu,

Zhang

et al. 2023

Phytotherapy Research

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Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists in many medicinal plants and has pharmacological effects such as anti‐atherosclerosis, antiplatelet aggregation, anti‐oxidation, and anti‐inflammatory, which keeps generally used in the treatment of cardiovascular and cerebrovascular diseases. Based on the therapeutic effects of Paeonol for cardiovascular and cerebrovascular diseases, this article reviewed the pharmacological effects of Paeonol in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, diabetes encephalopathy, and other neurological diseases, providing a reference for the research of the mechanism of Paeonol in central nervous system diseases.

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Section: Discussion and Further Perspectivementioning

confidence: 99%

Protective mechanism of Paeonol on central nervous system

Wu,

Liu,

Zhang

et al. 2023

Phytotherapy Research

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“…Epirubicin, a potent chemotherapeutic drug used in the treatment of breast cancer, was found to reduce cardiotoxicity and synergistically enhance anti-tumor responses in 4T1 cell tumor-bearing mice when treated with Paeonol [104]. In the context of adjuvant immunotherapy, there are no studies on the use of Paeonol in TNBC and other breast cancer subtypes; however, its adjunctive effects in melanomas have been implicated by targeting the immune checkpoint ligand PD-1 and regulating the microRNA miR-139-5p in thymocytes [145]. The compound is limited by its poor solubility in water and has low bioavailability and high volatility in normal conditions, rendering difficulty in drug delivery without modifications [146].…”

Section: Polyphenolsmentioning

confidence: 99%

Natural-Product-Derived Adjunctive Treatments to Conventional Therapy and Their Immunoregulatory Activities in Triple-Negative Breast Cancer

et al. 2023

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Triple-negative breast cancer (TNBC) is an invasive and persistent subtype of breast cancer that is likely to be resistant to conventional treatments. The rise in immunotherapy has created new modalities to treat cancer, but due to high costs and unreliable efficacy, adjunctive and complementary treatments have sparked interest in enhancing the efficacy of currently available treatments. Natural products, which are bioactive compounds derived from natural sources, have historically been used to treat or ameliorate inflammatory diseases and symptoms. As TNBC patients have shown little to no response to immunotherapy, the potential of natural products as candidates for adjuvant immunotherapy is being explored, as well as their immunomodulatory effects on cancer. Due to the complexity of TNBC and the ever-changing tumor microenvironment, there are challenges in determining the feasibility of using natural products to enhance the efficacy or counteract the toxicity of conventional treatments. In view of technological advances in molecular docking, pharmaceutical networking, and new drug delivery systems, natural products show promise as potential candidates in adjunctive therapy. In this article, we summarize the mechanisms of action of selected natural-product-based bioactive compounds and analyze their roles and applications in combination treatments and immune regulation.

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“…It was found that tumor progression was accompanied by accelerated thymic atrophy and apoptosis of thymocytes (differentiated CD4 + and CD8 + T cells) and that paeonol increased the mRNA levels of granzyme B in thymocytes and inhibited melanoma growth. Paeonol targets miR-139e5p to downregulate PD1 expression in the thymus to abolish immune dysfunction in melanoma ( Chen et al, 2023 ). This result suggests that paeonol has some immunomodulatory effects in combating tumor growth.…”

Section: Paeonol Anticancer Effectsmentioning

confidence: 99%

Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy

Chang

Feng

et al. 2023

Front. Pharmacol.

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Cancer represents one of the leading causes of mortality worldwide. Conventional clinical treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy. However, these treatments have inherent limitations, such as multidrug resistance and the induction of short- and long-term multiple organ damage, ultimately leading to a significant decrease in cancer survivors’ quality of life and life expectancy. Paeonol, a nature active compound derived from the root bark of the medicinal plant Paeonia suffruticosa, exhibits various pharmacological activities. Extensive research has demonstrated that paeonol exhibits substantial anticancer effects in various cancer, both in vitro and in vivo. Its underlying mechanisms involve the induction of apoptosis, the inhibition of cell proliferation, invasion and migration, angiogenesis, cell cycle arrest, autophagy, regulating tumor immunity and enhanced radiosensitivity, as well as the modulation of multiple signaling pathways, such as the PI3K/AKT and NF-κB signaling pathways. Additionally, paeonol can prevent adverse effects on the heart, liver, and kidneys induced by anticancer therapy. Despite numerous studies exploring paeonol’s therapeutic potential in cancer, no specific reviews have been conducted. Therefore, this review provides a systematic summary and analysis of paeonol’s anticancer effects, prevention of side effects, and the underlying mechanisms involved. This review aims to establish a theoretical basis for the adjunctive strategy of paeonol in cancer treatment, ultimately improving the survival rate and enhancing the quality of life for cancer patients.

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Paeonol inhibits melanoma growth by targeting PD1 through upregulation of miR-139-5p

Cited by 6 publications

References 33 publications

Protective mechanism of Paeonol on central nervous system

Protective mechanism of Paeonol on central nervous system

Natural-Product-Derived Adjunctive Treatments to Conventional Therapy and Their Immunoregulatory Activities in Triple-Negative Breast Cancer

Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy

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