Paeonol attenuates TNBS-induced colitis by inhibiting NF-κB and STAT1 transactivation

Ishiguro, Kazuhiro; Ando, Takafumi; Maeda, Osamu; Hasegawa, Mari; Kadomatsu, Kenji; Ohmiya, Naoki; Niwa, Yasumasa; Xavier, Ramnik J.; Goto, Hidemi

doi:10.1016/j.taap.2006.07.002

Cited by 70 publications

(52 citation statements)

References 22 publications

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“…35 Our data indicate that at 48 hours of TNBS instillation the levels of both TNF␣ and IFN␥ was significantly elevated and that the increase was partially inhibited by glutamine treatment (Table 2).…”

Section: Glutamine Inhibits Oxidative Stress and Cytokine Production mentioning

confidence: 56%

Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis

Filho

Fillmann

Mauriz

et al. 2008

Inflammatory Bowel Diseases

105

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Section: Glutamine Inhibits Oxidative Stress and Cytokine Production mentioning

confidence: 56%

Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis

Filho

Fillmann

Mauriz

et al. 2008

Inflammatory Bowel Diseases

105

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“…Unfortunately, despite many years of extensive research implicating immune dysfunction, genetic susceptibility, and bacterial flora within the intestinal environment as possible factors associated with development of the disease, its pathogenesis is still poorly understood. Several therapies including corticosteroids and sulfasalazine have been used for UC but these treatments cause serious side effects such as hormonal disturbance, peptic ulcers, liver dysfunction, and psychological problems (Sandborn and Targan, 2002;Ishiguro et al, 2006). Consequently, these adverse effects sometimes lead to discontinuation of corticosteroid treatment and result in acute UC exacerbation.…”

Section: Discussionmentioning

confidence: 99%

“…Most therapies for UC include glucocorticosteroids, sulfasalazine and other such drugs (Sandborn and Targan, 2002;Ishiguro et al, 2006). However, these treatments cause serious side effects and there is a pressing need for developing effective therapeutic approaches for UC.…”

Section: Introductionmentioning

confidence: 99%

Pulsatilla koreanaAmeliorates Ddextran Sulfate Sodium-induced Ccolitis in Mice

Kim

2015

BSL

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Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Pulsatilla koreana (P. koreana) is a perennial plant that grows around Korea and it has various pharmacological effects such as anti-cancer and anti-inflammatory activity. However, the regulatory effects of P. koreana in intestinal inflammation are not yet understood. This study attempted to determine the effect of P. koreana in dextran sulfate sodium (DSS)-induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of P. koreana attenuated DSS-induced the weight loss, colon shortening and Disease activity index in mice. Additionally, P. koreana inhibited the cyclooxygenase-2 and prostaglandin E 2 levels in DSS-treated colon tissues. These results provide experimental evidence that P. koreana might be a useful therapeutic medicine for patients with UC.

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“…Methyl Gallate (210) has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity, which might provide the basis for developing novel anti-inflammatory drugs [171]. While 185 had anti-anaphylactic activity by regulating histamine and TNF-a [172], paeonol enema might be useful for the treatment of colitis [173]. Compound 117, (À)-epigallocatechin gallate (137), gallacetophenone (212), but not gallic acid (209), significantly inhibited LPS-induced NO production in macrophages [108].…”

mentioning

confidence: 99%