Paeonol Attenuates the Endothelial-to-Mesenchymal Transition Induced
by TGF-β1 in Human Umbilical Vein Endothelial Cells through ALK5-
Smad2/3 Signaling Pathway
Abstract:Background:
Paeonol (Pae), the main active compound of the root of Paeonia albiflora, is efficacious in treating atherosclerosis (AS). Endothelial dysfunction is throughout the pathological progression of AS. It is expected that inhibition of Endothelial-to-mesenchymal transition (EndMT) will be a key target for AS treatment.
Objective:
In this study, we investigated the molecular mechanism of the regulatory effect of Pae on EndMT in human umbilical vein endothelial cells (HUVECs).
Methods:
Cell cytotoxici… Show more
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