Paediatric sequential organ failure assessment (pSOFA) score: a new mortality prediction score in the paediatric intensive care unit

El-Mashad, Ghada M; El-Mekkawy, Muhammad Said; Zayan, Mohamed Helmy

doi:10.1016/j.anpede.2019.11.001

Cited by 27 publications

(40 citation statements)

References 24 publications

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“…Previous studies also showed no significant differences between the gender, although slightly more boys had sepsis (54.7% and 52.7% respectively). 7,8 Pneumonia was the most common disease or the most source of infection, found in 63 (58.3%) subjects.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric SOFA score for detecting sepsis in children

Aulia

Triratna

Iriani

et al. 2020

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Background The pediatric logistic organ dysfunction-2 (PELOD-2) score is recommended by the Indonesian Pediatric Society Emergency and Intensive Care Working Group as an indicator of life-threatening organ dysfunction for sepsis in children. However, The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) recommended the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score in determining life-threatening organ dysfunction, which has not been adjusted for pediatric patients. Objective To assess the accuracy of the pediatric SOFA score in diagnosing sepsis in children admitted to the pediatric intensive care unit (PICU) at Mohammad Hoesin Hospital, Palembang, South Sumatera. Methods The study was conducted in children with organ dysfunction caused by infection admitted in PICU, from April to December 2019. Subjects were included by consecutive sampling, according to the following inclusion criteria: all patients aged 1 month to 18 years who met organ dysfunction and two SIRS criteria, with infection according to the 2005 PSCC criteria. Laboratory tests performed included complete blood count (CBC), blood gas analysis, measurement of C-reactive protein (CRP), liver and kidney function tests. In all patients, pSOFA and PELOD-2 scores were calculated within 24 hours of admission. We compared the accuracy of pSOFA score to PELOD-2 score ≥ 11. Results Of 108 subjects, there were 59 males and 49 females, with median age 11 (range 1-193) months. We compared the accuracy of pSOFA score to PELOD-2 score ≥ 11 and obtained a sensitivity of 93.3% and a specificity of 79.5%, for pSOFA cut-off score ≥ 8. Pediatric SOFA score cutoff ≥ 8 was determined by receiver operating curve (ROC). The area under the curve (AUC) for pediatric SOFA score was 93.9% (95%CI 89.7 to 98.0%). Conclusion Pediatric SOFA score ≥ 8 is the optimal cut-off for predicting life-threatening organ dysfunction in pediatric sepsis. Multicenter revalidation is needed to find the most optimal cut-off point for general use in Indonesia.

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Section: Discussionmentioning

confidence: 99%

“…5 Previous studies also noted a majority of subjects aged 1-11 months. 6,7 However, another study in the United States noted a higher mean age of 49 months. The age difference may have been due to their 8-252-month age range of subjects.…”

Section: Discussionmentioning

confidence: 99%

Pediatric SOFA score for detecting sepsis in children

Aulia

Triratna

Iriani

et al. 2020

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“…To guide the decision-making for the case definition and guidelines, a series of literature searches were performed using PubMed. The search terms and results of the searches are described in detail in [99] , [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] .…”

Section: Preamblementioning

confidence: 99%

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Muñoz

Cramer²,

Dekker

et al. 2021

Vaccine

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This is a Brighton Collaboration Case Definition of the term “Vaccine Associated Enhanced Disease” to be utilized in the evaluation of adverse events following immunization. The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. The case definition format of the Brighton Collaboration was followed to develop a consensus definition and defined levels of certainty, after an exhaustive review of the literature and expert consultation. The document underwent peer review by the Brighton Collaboration Network and by selected Expert Reviewers prior to submission.

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“…El-Mashad et al 14 dalam penelitian tentang pSOFA sebagai skor baru untuk pengukuran mortalitas pada anak di PICU menjelaskan bahwa Skor pSOFA berguna untuk memprediksi mortalitas 30 hari pada populasi PICU umum dan lebih baik daripada skor PRISM dan PIM2. Namun, pSOFA kurang berhasil dalam memprediksi lamanya pasien untuk dirawat di PICU.…”

Section: Perbandingan Psofa Dengan Skor Disfungsi Organ Yang Lainunclassified

Pediatric Sequential Organ Failure Assessment Score: Modifikasi Sistem Skor Pada Sepsis Anak

Dewi

2020

J Indon Med Assoc

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Pendahuluan: Society of Critical Care Medicine (SCCM) dan European Society of Intensive Care Medicine (ESICM) mengeluarkan definisi sepsis terbaru (Sepsis-3) yaitu disfungsi organ yang mengancam jiwa akibat disregulasi respon imun pejamu terhadap infeksi. Skor Sequential Organ Failure Assessment (SOFA) telah dipilih dan divalidasi sebagai sistem penilaian untuk mengukur disfungsi organ dikarenakan skor SOFA pada pasien dewasa dengan kecurigaan infeksi, sebanding atau bahkan lebih unggul daripada sistem penilaian lainnya dalam membedakan mortalitas rumah sakit. Untuk mengadaptasi definisi Sepsis-3, skor SOFA diadaptasi dan divalidasi untuk pasien anak-anak yang mengidap sakit kritis (pSOFA) dengan menggunakan kriteria yang telah disesuaikan berdasarkan usia. Hasil penelitian menunjukan perkiraan mortalitas pada pSOFA saat waktu kedatangan, hari 2, 4, 7 dan 14 setelah masuk Pediatric Intensive Care Unit (PICU) lebih baik dibandingkan skor disfungsi organ lainnya. Evaluasi serial dari skor pSOFA pada hari pertama setelah masuk PICU juga sangat baik dalam memprediksi prognosis dari pasien pediatri onkologi yang memakai ventilator selama 3 hari, anak-anak dengan sepsis di PICU dan berguna untuk memprediksi mortalitas 30 hari pada populasi PICU, namun kurang berhasil dalam memprediksi lamanya pasien untuk dirawat di PICU.

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Paediatric sequential organ failure assessment (pSOFA) score: a new mortality prediction score in the paediatric intensive care unit

Cited by 27 publications

References 24 publications

Pediatric SOFA score for detecting sepsis in children

Pediatric SOFA score for detecting sepsis in children

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

Pediatric Sequential Organ Failure Assessment Score: Modifikasi Sistem Skor Pada Sepsis Anak

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