Paediatric progressive primary tuberculosis

Yogo, Naoki; Furukawa, Chihiro; Hayano, Satoshi

doi:10.1016/j.jctube.2022.100318

Cited by 2 publications

(2 citation statements)

References 5 publications

(4 reference statements)

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“…Geographically speaking, Africa and Asia bear the brunt of TB. Nearly 40% of TB cases worldwide are reported in China and India [1][2][3][4]. Rifampicin is a semisynthetic anti-microbial delivered from Streptomyces mediterranei.…”

Section: Introductionmentioning

confidence: 99%

“…A few different forms of Mycobacteria are resistant to its broad antimicrobial range. It stifles the beginning of RNA synthesis in defenceless living things by impeding DNA-subordinate RNA polymerase action by creating a stable complex with the molecule [1][2][3][4]. Antituberculosis drugs cause hepatotoxicity in certain people prompting intense liver disappointment, which brings about death.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemometric-Assisted UV-Spectrophotometric Method for Quantification of Novel Anti-Tubercular Liquisolid Formulation

Tandel¹,

Patel²,

Thakkar³

et al. 2023

Int J Pharm Res Allied Sci

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To simultaneously determine quercetin and rifampicin in raw material and liquid-solid formulation, a numerical technique built on spectroscopic data associated with partial least squares (PLS) multi -variate measurement is suggested in this work. Rifampicin and quercetin spectra were captured at concentrations that fell within the 2-10 µg/ml linear range for each compound. They were used to compute 25 simulated mixtures containing 16 calibration and 9 validation sets, with wavelength spacing of λ=15 nm in hydrochloric acid (0.1 M) and phosphate buffer pH-6.8. The wavelength ranges were 200 to 630 nm. Based on the validation and calibration data's (RMSE) root mean square errors, the models' appropriateness was determined. Recovery studies (%) and relative prediction errors were used to compare and contrast the analytical capabilities of various chemometric techniques. The recovery study's findings showed that this technique was successfully used to formulate pharmaceuticals without excipient interference. The suggested technique is quick, easy to use, and can be utilised as a replacement for traditional analytical tools in the formulation and quality control of pharmaceuticals.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%