Paediatric pancreatic diseases

Coffey, Michael J.; Ooi, Chee Y.

doi:10.1111/jpc.14688

Cited by 4 publications

(8 citation statements)

References 47 publications

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“…This study, which used fasting blood sugar and HbA1c as screening tools, reported one patient (7.1%) with diabetes mellitus, comparable to 4–9% in children with CP from other reports 41,42 . An oral glucose tolerance test is also indicated in patients with CP, 3 particularly when the patients have a pre‐diabetes range of fasting blood sugar or HbA1c levels 41 …”

Section: Discussionmentioning

confidence: 61%

“…Moreover, annually monitoring of fat-soluble vitamins is recommended in patients with CP and should be considered in patients with ARP. 3,41 Four patients were documented with a suboptimal level of the vitamins in this study. However, the monitoring was only available in the last 10 years at our institute.…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatitis, an inflammation process of the pancreas, 1 is the most common pancreatic disorder in children. 2,3 Pediatric pancreatitis can be divided into acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP). 4 While the inflammation in AP is reversible, 2 the pathophysiology of CP is characterized by progressive pancreatic fibroinflammation leading to exocrine and endocrine pancreatic insufficiency (PI).…”

mentioning

confidence: 99%

“…Pancreatitis, an inflammation process of the pancreas, 1 is the most common pancreatic disorder in children 2,3 . Pediatric pancreatitis can be divided into acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) 4 .…”

mentioning

confidence: 99%

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Etiology and outcome of acute recurrent pancreatitis and chronic pancreatitis

Getsuwan

Tanpowpong

Lertudomphonwanit

et al. 2022

Pediatrics International

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Background Owing to the lack of data, we aimed to determine the etiology and outcome of acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) in children in Southeast Asia. Methods This retrospective study was conducted at a university hospital in Bangkok, Thailand. We included patients aged <18 years who were diagnosed with pancreatitis from 2000 to 2021. Results Among 155 patients with pancreatitis, 21 (13.5%) were diagnosed with either ARP (n = 7) or CP (n = 14). Clinical manifestations of CP included chronic abdominal pain (n = 10, 71.4%), steatorrhea (n = 8, 57.1%), and diabetes mellitus (n = 1, 7.1%). Positive radiological findings compatible with CP were detected from an abdominal ultrasound, computed tomography, magnetic resonance cholangiopancreatography in 70%, 90.9%, and 92.9% of patients, respectively. Genetic, metabolic, and pancreaticobiliary causes were the major causes of ARP/CP (23.8% each) and the etiologies were unidentified in one‐fifth of the patients. Patients with metabolic diseases who had AP were at‐risk of developing ARP (hazards ratio [HR], 4.7, 95% confidence interval [CI]: 1.5–13.9). Children with ARP or CP were younger than those with AP (P = 0.04). Approximately two‐thirds of patients with CP had growth faltering and they had more episodes of hospitalization due to acute attacks when compared to patients with ARP ( 4 [interquartile range [IQR], 3–6] vs. 3 [IQR, 2–3]; P = 0.02). Conclusion Genetic, metabolic, and pancreaticobiliary diseases were the common etiologies of ARP and CP among children living in a developing country in Southeast Asia. The burden of CP included malnutrition and frequent hospitalization. The findings emphasize the importance of an early etiological diagnosis and monitoring for pancreatic insufficiency in ARP/CP.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Etiology and outcome of acute recurrent pancreatitis and chronic pancreatitis

Getsuwan

Tanpowpong

Lertudomphonwanit

et al. 2022

Pediatrics International

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“…2019; Li et al . 2019), cystic fibrosis (Coffey and Ooi 2020), inflammatory bowel disease (Fofanova et al . 2016), Crohn's disease and irritable bowel syndrome (Gu et al .…”

Section: Human Milk Microbiota: Diversitymentioning

confidence: 99%

Bio‐therapeutics from human milk: prospects and perspectives

Singh

Rokana

et al. 2021

J Appl Microbiol

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Human milk is elixir for neonates and is a rich source of nutrients and beneficial microbiota required for infant growth and development. Its benefits prompted research into probing the milk components and their use as prophylactic or therapeutic agents. Culture-independent estimation of milk microbiome and high-resolution identification of milk components provide information, but a holistic purview of these research domains is lacking. Here, we review the current research on bio-therapeutic components of milk and simplified future directions for its efficient usage. Publicly available databases such as PubMed and Google scholar were searched for keywords such as probiotics and prebiotics related to human milk, microbiome and milk oligosaccharides. This was further manually curated for inclusion and exclusion criteria relevant to human milk and clinical efficacy. The literature was classified into subgroups and then discussed in detail to facilitate understanding. Although milk research is still in infancy, it is clear that human milk has many functions including protection of infants by passive immunization through secreted antibodies, and transfer of immune regulators, cytokines and bioactive peptides. Unbiased estimates show that the human milk carries a complex community of microbiota which serves as the initial inoculum for establishment of infant gut. Our search effectively screened for evidence that shows that milk also harbours many types of prebiotics such as human milk oligosaccharides which encourage growth of beneficial probiotics. The milk also trains the naive immune system of the infant by supplying immune cells and stimulatory factors, thereby strengthening mucosal and systemic immune system. Our systematic review would improve understanding of human milk and the inherent complexity and diversity of human milk. The interrelated functional role of human milk components especially the oligosaccharides and microbiome has been discussed which plays important role in human health.

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Making Research Flourish Through ESPGHAN

Gasparetto

Strisciuglio

Assa

et al. 2021

J. pediatr. gastroenterol. nutr.

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Recent research breakthroughs have emerged from applied basic research throughout all scientific areas, including adult and paediatric gastroenterology, hepatology and nutrition (PGHAN). The research landscape within the European Society of Paediatric Gastroenterology and Nutrition (ESPGHAN) is also inevitably changing from clinical research to studies involving applied laboratory research. This position paper aims to depict the current status quo of basic science and translational research within ESPGHAN, and to delineate how the society could invest in research in the present and future time. The paper also explores which research areas in the field of PGHAN represent the current and future priorities, and what type of support is needed across the ESPGHAN working groups (WGs) and special interest groups (SIGs) to fulfil their research goals.

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Paediatric pancreatic diseases

Cited by 4 publications

References 47 publications

Etiology and outcome of acute recurrent pancreatitis and chronic pancreatitis

Etiology and outcome of acute recurrent pancreatitis and chronic pancreatitis

Bio‐therapeutics from human milk: prospects and perspectives

Making Research Flourish Through ESPGHAN

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