Paediatric osteofibrous dysplasia-like adamantinoma with classical radiological findings

Ondhia, Meraj; Garg, Neeraj; Vaiyapuri, Sumathi; Harave, Srikrishna

doi:10.1136/bcr-2018-224487

Cited by 3 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Classic AD is a low-grade tumor with metastatic potential that requires aggressive surgery with wide margins, as it is not sensitive to chemotherapy and radiotherapy. In the literature and in the current study, OFD-like AD followed a benign but aggressive course [ 9 , 11 – 13 , 20 ]. There are some reports of LR of OFD-like AD, but no reports of distant metastasis.…”

Section: Discussionmentioning

confidence: 92%

“…Another study that included five patients with OFD-like AD treated with curettage reported three cases of LR, but no metastasis or progression to classic AD [ 20 ]; two of the three patients with LR had pathological fractures, which might negatively affect local control [ 20 ]. Another three isolated case reports of OFD-like AD have reported no distant metastasis [ 11 – 13 ]. In the current study, the incidence of LR of OFD-like AD was 14.3%, and there was no metastasis detected.…”

Section: Discussionmentioning

confidence: 99%

“…There are also differences between OFD-like AD and classic AD regarding the clinical characteristics and prognosis. However, most reports about OFD-like AD are case reports or small case series [ 9 , 11 – 14 ]. Thus, more cases from different centers are still warranted.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience

et al. 2020

View full text Add to dashboard Cite

Background The clinical and molecular characteristics of osteofibrous dysplasia (OFD)-like adamantinoma (AD) differ from those of classic AD. Most reports about OFD-like AD are case reports or small case series. More cases from different centers are still warranted. Methods The orthopedic oncology database of our institution was searched to identify patients with AD. The cases of OFD-like and classic AD of the long bones were retrospectively analyzed. Between December 1999 and August 2016, 23 patients were treated for AD, comprising seven with OFD-like AD and 16 with classic AD. The outcomes were compared between AD subtypes. Results In the OFD-like AD group, four lesions were treated with extensive curettage, while three were treated with wide resection. The median follow-up duration in the OFD-like AD group was 66 months (range 43–131 months). At the end of follow-up, there was only one case of local recurrence (LR) in the OFD-like AD group, giving a LR rate of 14.3% (1/7). No distant metastasis or progression to classic AD was detected in the OFD-like AD group. In the classic AD group, the treatments were below-the-knee amputation in one patient with extensive tibial and fibular lesions, curettage with a bone graft in one patient who was diagnosed with OFD based on a core needle biopsy, hemi-cortical excision and reconstruction in two patients, and segmental resection and reconstruction in 12 patients. At the end of follow-up, there were three cases of LR in the classic AD group, giving a LR rate of 18.8% (3/16); two patients developed lung metastasis after LR and died of the disease at 88 and 126 months after the first surgery in our hospital, respectively. The classic AD group had a metastatic rate of 12.5% (2/16), a final limb salvage rate of 75%, and estimated 5- and 10-year survival rates of 88.9% and 77.1%, respectively. Conclusions OFD-like AD has a better outcome than classic AD. For OFD-like AD, extensive curettage is suggested if the tumor extent allows. For classic AD, aggressive resection with wide margins is essential to achieve local control. A long-term follow-up is necessary due to the possibility of late complications.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[12,13] The typical appearance of adamantinoma would be a lytic expansile lesion with narrow transition zone, with typical soap bubble appearance, which is not seen in this patient. [12,14] It was also reported that 60% of patients had preceding history of trauma of the affected leg. [1] Soft tissue extension is reported in less than 15% of cases, in which the patient has.…”

Section: Discussionmentioning

confidence: 99%

Osteo-fibrous Dysplasia like Adamantinoma: A Diagnostic Dilemma

Setia

Ros

Ismail

et al. 2022

Preprint

View full text Add to dashboard Cite

Osteofibrous dysplasia-like adamantinoma is a rare, intermediate grade primary bone tumour of unknown aetiology, which typically involve mid-tibia diaphyseal region. We present a case which was initially suspected as metastasis as patient had underlying colonic cancer. Biopsy was taken twice for confirmatory diagnosis. Patient had an atypical imaging presentation of OFD-like adamantinoma, as the age of the patient and radiographical presentation were more of a classic adamantinoma. The ability to recognize the pattern and distribution and keeping it as a differential is important. MRI findings would be non-specific, but useful in term of locoregional staging. Even though histopathological examination provides definite diagnosis, it may sometimes yield false negative. Bone scan can be useful in detecting primary and metastatic osteoblastic bone tumour. Imaging findings and its closest differentials were discussed.

show abstract

Osteofibrous dysplasia: a narrative review

Liu,

Tong,

et al. 2024

J Orthop Surg Res

View full text Add to dashboard Cite

Osteofibrous dysplasia (OFD) is a rare, benign, self-limited bone disorder with a relatively low incidence, accounting for approximately 0.2% of all primary bone tumors. It was frequently found intra-cortical of the mid-shaft of the tibia. OFD can also occur in other skeletal regions, including the fibula, ulna, radius, femur, humerus, ischium, rib, tarsus, metatarsals, vertebral, and capitate. OFD can present with asymptomatic, mass, pain, swelling, deformity, and even pathological fracture. OFD might be misdiagnosed as adamantinoma (AD) and because they are three subtypes origin from the same family of bone tumors and have similar imaging features. Moreover, pathology could provide evidence for an accurate diagnosis of OFD, but misdiagnosis may occur due to small sampling materials. To date, few studies have comprehensively introduced the epidemiology, clinical manifestations, pathogenesis, radiological features, pathology, and treatment for OFD. We herein discuss clinical signs, diagnosis methods, and treatment options of OFD to improve the understanding of OFD, which is helpful for accurate diagnosis and appropriate treatment.

show abstract

Paediatric osteofibrous dysplasia-like adamantinoma with classical radiological findings

Cited by 3 publications

References 3 publications

Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience

Outcome of osteofibrous dysplasia-like versus classic adamantinoma of long bones: a single-institution experience

Osteo-fibrous Dysplasia like Adamantinoma: A Diagnostic Dilemma

Osteofibrous dysplasia: a narrative review

Contact Info

Product

Resources

About