Paediatric optical coherence tomography normative databases: A real need

Muñoz-Gallego, A.; Rodríguez‐Salgado, Martín; Cruz, Javier de la; López-López, Cristina; Cañas-Zamarra, Ignacio; Tejada-Palacios, P.

doi:10.1016/j.oftale.2019.08.003

Cited by 1 publication

(2 citation statements)

References 41 publications

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“…As none of the currently available OCT devices include a normative database for the paediatric population, 22 age-appropriate comparison data was collected in a group of 140 healthy children and young adults of 5–25 years of age ( Table 1 ). Exclusion criteria were any ophthalmological or neurological disease, prematurity, large refractive errors > +6 Dioptres (D) or < −6 D, anisometropia, strabismus or amblyopia.…”

Section: Methodsmentioning

confidence: 99%

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Optical Coherence Tomography Can Predict Visual Acuity in Children with Optic Nerve Hypoplasia

Skriapa-Manta¹,

Nilsson²,

Svoboda³

et al. 2022

OPTH

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Optic nerve hypoplasia (ONH) is a common cause of visual impairment in children. Clinical complexity can cause diagnostic delay and difficulties predicting visual outcome. We evaluated whether optical coherence tomography (OCT) can improve the diagnosis and prediction of vision. Methods: Thirty-seven eyes with ONH from 12 girls and 8 boys, median age 10.5 years (range 2.8-18.9 years), were included in this cross-sectional cohort study. The majority, 17/20, had bilateral ONH. Ophthalmological assessments included best corrected visual acuity (BCVA), fundus photography, measurement of the peripapillary retinal nerve fibre layer (pRNFL), macular ganglion cell complex (GCC), Bruch's membrane opening (BMO) and visual fields. We compared OCT parameters with comparison data collected on 140 healthy individuals 5 to 25 years old. Pearson's correlation coefficient was used to determine the correlation of OCT parameters and BCVA. Results: OCT demonstrated thinner mean pRNFL (p < 0.001) and mean GCC compared to the reference material (p < 0.001). BCVA displayed a strong or moderate correlation to pRNFL and to all sectors of the GCC except the inferotemporal. BCVA correlated strongly to Bruch's membrane opening (BMO) (0.71, p < 0.001), and moderately to the Zeki ratio (−0.52, p < 0.001). Multivariate analyses showed that BMO explained 48% of the variance in BCVA. Visual fields correlated strongly to pRNFL and GCC thickness. GCC thinning corresponded to visual field defects presence and location. Conclusion: OCT can facilitate the diagnosis of ONH. Parameters such as pRNFL, GCC and BMO can be predictors of visual acuity whereas GCC and pRNFL thinning can indicate location and severity of visual field defects.

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Section: Methodsmentioning

confidence: 99%

“…As none of the currently available OCT devices include a normative database for the paediatric population, 22 ageappropriate comparison data was collected in a group of 140 healthy children and young adults of 5-25 years of age…”

Section: Reference Datamentioning

confidence: 99%