Paediatric musculoskeletal matters (pmm) – collaborative development of an online evidence based interactive learning tool and information resource for education in paediatric musculoskeletal medicine

Smith, Nicola; Rapley, Tim; Jandial, Sharmila; English, Christine; Davies, Barbara; Wyllie, Ruth; Foster, Helen

doi:10.1186/s12969-015-0062-4

Cited by 33 publications

(24 citation statements)

References 21 publications

(19 reference statements)

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“…With both sources, nonoverlapping results were obtained with regard to differential microRNA expression between the patient groups 22. In pediatric lupus patients, a relationship between the level of several urinary microRNAs and lupus nephritis activity was found when cell‐free supernatant was used, but not with the cell pellet 23. These studies indicate that using several sources of urinary microRNA can have added value.…”

Section: Methodology For Measuring Micrornas In Urinementioning

confidence: 93%

“…Items for which the interindividual variation should be minimized in kidney transplant recipients include the donor source (living vs. deceased), donor age, interval after transplantation, type of immunosuppressive medication, and viral infections (especially cytomegalovirus and BKV). Because urinary cell pellets, cell‐free urine, and urinary exosomes can yield different outcomes 22, 23, consideration should be given to evaluate these urinary microRNA sources in parallel because they can all be obtained from the same urinary specimen. Uniform protocols should be applied for the isolation of microRNA and the measurement of its concentration.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

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Urinary MicroRNA as Biomarker in Renal Transplantation

Vrie

Deegens

Eikmans

et al. 2017

American Journal of Transplantation

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Urine represents a noninvasive source in which proteins and nucleic acids can be assessed. Such analytes may function as biomarkers to monitor kidney graft pathology at every desired frequency, thereby providing a time window to prevent graft damage by therapeutic intervention. Recently, several proteins have been measured in urine as markers of graft injury. However, the specificity is limited, and measuring urinary proteins generally lacks the potential to predict early kidney graft damage. Currently, urinary mRNA and microRNA are being investigated to evaluate the prognostic value of changes in gene expression during the initial stages of graft damage. At such time point, a change in treatment regimen and dosage is expected to have maximum potency to minimize future decline in graft function. Both mRNA and microRNAs have shown promising results in both detection and prediction of graft injury. An advantage of microRNAs compared to mRNA molecules is their stability, a characteristic that is beneficial when working with urine samples. In this review, we provide the current state of urinary biomarkers in renal transplantation, with a focus on urinary microRNA. In addition, we discuss the methods used to study urinary microRNA expression.

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Section: Methodology For Measuring Micrornas In Urinementioning

confidence: 93%

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Urinary MicroRNA as Biomarker in Renal Transplantation

Vrie

Deegens

Eikmans

et al. 2017

American Journal of Transplantation

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“…The paediatric GALS (pGALS) [62,86] examination tool was designed specifically for use by medical students and P C P s ( p a e d i a t r i c R e g i o n a l E x a m i n a t i o n o f t h e Musculoskeletal System [pREMS] was developed for postgraduate training) [87]. To further support students and nonspecialists who lack confidence in performing the pGALS examination and diagnosing paediatric MSK conditions, a free online resource called Paediatric Musculoskeletal Matters (PMM) [88,89] was developed (Table 3). While simple paediatric MSK physical examination tools do exist, an adequate knowledge base is a prerequisite for the interpretation of clinical findings [33].…”

Section: Gals and Pgalsmentioning

confidence: 99%

“…To support students and non-specialists who lack confidence in performing the pGALS examination and diagnosing paediatric MSK conditions [88,89]. PMM is endorsed by professional organisations (Paediatric Rheumatology European Society [PReS], British Society for Paediatric and Adolescent Rheumatology [BSPAR]) and NICE.…”

Section: Paediatric Musculoskeletal Matters (Pmm)mentioning

confidence: 99%

A global perspective on the challenges and opportunities in learning about rheumatic and musculoskeletal diseases in undergraduate medical education

et al. 2019

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Rheumatic and musculoskeletal diseases (RMDs) encompass a spectrum of degenerative, inflammatory conditions predominantly affecting the joints. They are a leading cause of disability worldwide and an enormous socioeconomic burden. However, worldwide deficiencies in adult and paediatric RMD knowledge among medical school graduates and primary care physicians (PCPs) persist. In October 2017, the World Forum on Rheumatic and Musculoskeletal Diseases (WFRMD), an international think tank of RMD and related experts, met to discuss key challenges and opportunities in undergraduate RMD education. Topics included needs analysis, curriculum content, interprofessional education, teaching and learning methods, implementation, assessment and course evaluation and professional formation/career development, which formed a framework for this white paper. We highlight a need for all medical graduates to attain a basic level of RMD knowledge and competency to enable them to confidently diagnose, treat/manage or refer patients. The importance of attracting more medical students to a career in rheumatology, and the indisputable value of integrated, multidisciplinary and multiprofessional care are also discussed. We conclude that RMD teaching for the future will need to address what is being taught, but also where, why and to whom, to ensure that healthcare providers deliver the best patient care possible in their local setting.

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“…The PMM website (www.pmmonline.org) is a free and open evidence based, peer reviewed e-resource with user engagement to inform content and website design functionality (19). PMM Nursing (2017) is a further version of PMM to address the needs of the wider nursing community (17).…”

Section: Introductionmentioning

confidence: 99%

A Mixed Methods Evaluation of The Paediatric Musculoskeletal Matters (PMM) Online Portfolio

Smith

Foster

Jandial

2020

Preprint

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Background Electronic resources (e-resources) have considerable potential to reach users around the world to promote awareness and knowledge about musculoskeletal conditions. The ‘PMM portfolio’ targets non-specialists in musculoskeletal medicine and comprises the Paediatric Musculoskeletal Matters (PMM) website, the paediatric Gait, Arms, Legs and Spine (pGALS) app and e-learning modules (ELM). Our aim was to evaluate the ‘PMM portfolio’ to gain insights about it’s impact on learning and clinical practice. Methods Mixed methods (e-resource analytics, online survey, interviews) with PMM and ELM registered users in addition to purposive sampling of users using UK and international contacts within paediatrics and paediatric rheumatology. Data was analysed using descriptive statistics and free-text comments using qualitative techniques. A Paired T-Test compared self-rated confidence before and after use of the e-resources. Results There has been wide international reach for all e-resources PMM website (662,827 hits, 262,476 users, 214 countries, data 31st July 2020), pGALS app (12,670 downloads, 70 countries, data 31st July 2020); ELM (150 users, 30 countries, data 30th May 2019). There were 164 responses to the survey from 25 countries from a range of students, trainees and health care professionals. Most deemed the ‘PMM portfolio’ to be ‘useful or very useful’ for their learning (or when used to teach others) and reported significantly increased self-rated confidence in their clinical examination and reasoning skills following access to the e-resources (PMM website, p=<0.01; pGALS app, p=<0.01; ELM, p=<0.01). Easy, open access, clinical images, videos and cases were deemed the most valued features of the e-resources. The most popular PMM website pages related to clinical assessment. There was high uptake of the pGALS app and pGALS’ ELM especially from trainees and allied health professionals. Conclusions The ‘PMM portfolio’ has wide reach amongst a spectrum of our target users to raise awareness and improve knowledge and skills. Ongoing engagement with users will facilitate further iterations of the ‘PMM portfolio’ to remain relevant for the global context. PMM as a model of e-learning has increasing applicability with the ongoing Covid-19 pandemic and is an important way to expand global paediatric rheumatology.

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Paediatric musculoskeletal matters (pmm) – collaborative development of an online evidence based interactive learning tool and information resource for education in paediatric musculoskeletal medicine

Cited by 33 publications

References 21 publications

Urinary MicroRNA as Biomarker in Renal Transplantation

Urinary MicroRNA as Biomarker in Renal Transplantation

A global perspective on the challenges and opportunities in learning about rheumatic and musculoskeletal diseases in undergraduate medical education

A Mixed Methods Evaluation of The Paediatric Musculoskeletal Matters (PMM) Online Portfolio

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