Paediatric massive transfusion

Blain, Stuart; Paterson, Neil

doi:10.1093/bjaed/mkv051

Cited by 19 publications

(16 citation statements)

References 11 publications

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“…Pediatric population is especially vulnerable to massive bleeding due to an immature hemostatic mechanism such as low coagulant and procoagulant concentration as well as relatively dysfunctional fibrinogen. 10 This study demonstrated that massive bleeding occurred in 31 out of 34 cases (91%).…”

Section: Discussionmentioning

confidence: 69%

“…For this reason, signs and symptoms of hypovolemia cannot be used as a predictor of early blood loss. 10 Nacoti, et al reported that bleeding volume and allogeneic red cell transfusion affected patient and transplant outcome. 12 It is also interesting to note that there was a discrepancy in the bleeding volume and the transfused PRC volume reported in this study.…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with the need for intraoperative packed red cells transfusion in pediatric liver transplant patients

Kapuangan

Utariani

Hanindito

2019

Bali J Anaesthesiol

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Background: Massive hemorrhage is one of the most common problems encountered during a liver transplantation procedure. Correction of the blood loss using packed red cells (PRC) is essential during the procedure to improve outcome. This retrospective study aims to investigate preoperative and intraoperative factors that may predict the PRC need. Materials and methods: Thirty-four patients who underwent pediatric liver transplantation procedure within 2010-2018 were included in this study. Their medical record was examined and the data was analyzed using a comparison of mean and regression model. Results:The mean bleeding in this study was found to be 906.62±674.30 mL, while the mean PRC transfusion was 566.71±307.30 mL. Correction of blood loss was also compensated with other means such as a crystalloid or colloid fluid. Conclusion:This study statistically demonstrated that pre-operative weight, as well as bleeding volume, significantly affect the PRC transfusion requirement (p <0.05). However, other factors such as hemoglobin and surgical duration may also be clinically significant factors to predict PRC transfusion need. Cite This Article: Kapuangan, C., Utariani, A., Hanindito, E. 2019. Factors associated with the need for intraoperative packed red cells transfusion in pediatric liver transplant patients.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Factors associated with the need for intraoperative packed red cells transfusion in pediatric liver transplant patients

Kapuangan

Utariani

Hanindito

2019

Bali J Anaesthesiol

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“…Hypocalcaemia and hypokalaemia were observed after transfusion of two units of pRBC and one unit of FFP alongside the administration of Hartmann's solution and gelatin based colloids. This can be caused by dilutional effects, citrate overload, hypoproteinemia and re-entry of electrolytes into transfused cells (Blain and Paterson, 2016). There were no changes on the electrocardiogram, such as a prolonged QT interval or inversion of the T wave (Chodan and Davidow, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Tranexamic acid (TA) is an antifibrinolytic drug. In people there is evidence that when administered during active bleeding it reduces blood loss and requirements for blood transfusion (Blain and Paterson, 2016). Tranexamic acid has been evaluated in healthy dogs and has been reported to be safe at clinical doses of 10 mg/kg (Kelmer et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Management of massive blood loss in a dog under general anaesthesia during a sternotomy

Chevallier¹,

Love

2019

Companion Animal

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A 2-year-old male neutered American Staffordshire Terrier was presented collapsed, with tachycardia, dyspnoea and pale mucous membranes. An emergency sternotomy and lateral thoracotomy was performed. Before surgery the dog's blood was typed and found to be DEA negative. The dog lost the equivalent of its entire blood volume (estimated) during the first hour of surgery. Cardiovascular parameters initially responded to boluses of crystalloids and colloids. He also received transfusions of DEA negative packed red blood cells and fresh frozen plasma. Due to ongoing haemorrhage, the dog's clinical condition, and a lack of availability of any more DEA negative blood products, the decision was made to give a unit of DEA positive packed red blood cells. The dog recovered uneventfully, although following diagnosis of an aggressive soft tissue sarcoma the dog was later euthanased. This report discusses the management of massive blood loss in veterinary medicine and the implications, potential options for management, and treatment of these cases perioperatively.

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Fluid Management in Children Undergoing Surgery and Anesthesia

Bergesio

Johnson

2019

A Guide to Pediatric Anesthesia

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Paediatric massive transfusion

Cited by 19 publications

References 11 publications

Factors associated with the need for intraoperative packed red cells transfusion in pediatric liver transplant patients

Factors associated with the need for intraoperative packed red cells transfusion in pediatric liver transplant patients

Management of massive blood loss in a dog under general anaesthesia during a sternotomy

Fluid Management in Children Undergoing Surgery and Anesthesia

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