Paediatric inflammatory bowel disease in India: a prospective multicentre study

Srivastava, Anshu; Sathiyasekharan, Malathi; Jagadisan, Barath; Bolia, Rishi; Peethambaran, Maya; Mammayil, Geetha; Acharya, Bhaswati; Malik, Rohan; Sankaranarayanan, Srinivas; Biradar, Vishnu; Malhotra, Smita; Mathew, Philip; Poddar, Ujjal; Yachha, Surender Kumar

doi:10.1097/meg.0000000000001859

Cited by 13 publications

(15 citation statements)

References 34 publications

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“…According to a recent systematic review, the incidence of IBD, CD, and UC were each 0.5-11.4, 0.3-3.7, and 0.2-3.9 per 100,000 person-years, respectively, from 1968 to 2012 (8). However, when compared to the adult data on IBD epidemiology, there are still very few studies from Asian countries with relatively high population such as China, India, and Central Asia (17)(18)(19)(20). Owing to the limited data regarding pediatric IBD epidemiology in Asia, this study may be an important piece of the puzzle to define the epidemiology of pediatric IBD in the region.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

Choe

Choi

Song³

et al. 2022

Front. Pediatr.

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Background and Aim: There is paucity of data regarding the epidemiology of pediatric IBD in Asia compared to that of Western countries. We aimed to investigate the incidence and prevalence trends of pediatric inflammatory bowel disease (IBD) in the Daegu-Kyungpook province of South Korea from 2017 to 2020.Methods: This study was a multicenter, retrospective study conducted in eight IBD referral centers located in the Daegu-Kyungpook province. Children and adolescents of ≤18 years who were initially diagnosed with IBD between 2017 and 2020 were included. The annual number of children and adolescents newly diagnosed with IBD and the annual resident population of children and adolescents ≤18 years of age in the Daegu-Kyungpook province were investigated to calculate the annual incidence and prevalence in the region.Results: A total 304 children and adolescents that had been diagnosed with IBD were included in this study. Among these patients, 71.4% had been diagnosed with Crohn's disease (CD), and 28.6% with ulcerative colitis (UC). The population based annual incidences of IBD from 2017 to 2020 were each 7.24, 6.82, 10.27, and 13.33 per 100,000, respectively (P for trend <0.001), 4.48, 5.26, 7.39, and 9.8 per 100,000, respectively, for CD (P for trend <0.001), and 2.76, 1.56, 2.88, and 3.53 per 100,000, respectively, for UC (P for trend = 0.174).Conclusion: Pediatric IBD, especially CD has significantly increased recently in the Daegu-Kyungpook province. Epidemiology studies from other regions of Asia are required to better elucidate this trend of increase in Asia.

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Section: Discussionmentioning

confidence: 99%

Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

Choe

Choi

Song³

et al. 2022

Front. Pediatr.

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“…Of interest, VEO‐IBD was phenotypically often unclassified and presented with diarrhea or rectal bleeding, while EO‐IBD and adolescent IBD were more like CD and presented with abdominal pain and diarrhea. Fifty‐six percent (13/23) of the VEO‐IBD patients in this study had an IBD‐U phenotype compared to 30% in a recent study from India 29 . Perineal and perianal disease occurred in about 52% of VEO‐IBD patients, indicating the aggressive nature of the disease.…”

Section: Discussionmentioning

confidence: 44%

“…Fifty-six percent (13/23) of the VEO-IBD patients in this study had an IBD-U phenotype compared to 30% in a recent study from India. 29 Perineal and perianal disease occurred in about 52% of VEO-IBD patients, indicating the aggressive nature of the disease. A positive family history was present in 21.7% of VEO-IBD.…”

Section: Discussionmentioning

confidence: 99%

“…The histological findings reported on colonic mucosal biopsies from patients with UC included lamina propria inflammation (496), cryptitis (431), crypt distortion (402), crypt abscesses (311), and granulomas (22). In IBD-U patients, findings reported on mucosal biopsy included mucosal inflammation (68), crypt distortion (29), cryptitis (28), and crypt abscesses (25). Interestingly, 20 of 84 (23.8%) IBD-U patients were reported to have granulomas on mucosal biopsy.…”

Section: Adult Ibdmentioning

confidence: 99%

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Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices

et al. 2021

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BackgroundInflammatory bowel disease (IBD) is increasingly diagnosed in South Asia. This survey by the Tamil Nadu Chapter of the Indian Society of Gastroenterology (TNISG) documents the demography, clinical profile, and therapeutic practices related to IBD in Tamil Nadu.MethodsTNISG members from 32 institutions completed an online cross‐sectional questionnaire on IBD patients from March 2020 to January 2021.ResultsOf 1295 adult IBD patients, 654 had Crohn's disease (CD), 499 ulcerative colitis (UC), and 42 IBD‐unclassified (IBD‐U). CD and UC showed a unimodal age distribution. A total of 55% were graduates or postgraduates. A positive family history was noted in 30, other risk factors were uncommon. In CD, the pattern of involvement was ileocolonic (42.8%), ileal (34.7%), colonic (18.9%), and upper gastrointestinal (3.5%); while in UC, disease was characterized as extensive (44.9%), left‐sided (41.7%), or proctitis (13.4%). Perineal disease, perianal fistulae, and bowel obstruction were noted in 4.3, 14.0, and 23.5%, respectively, of CD. The most widely used drugs were mesalamine, azathioprine, and corticosteroids. Surgery was undertaken in 141 patients with CD and 23 patients with UC. Of the 138 patients with pediatric IBD (≤16 years), 23 were characterized as very early onset IBD (VEO‐IBD), 27 as early‐onset, and 88 as adolescent IBD. VEO‐IBD were more likely to have a positive family history of IBD and were more likely to have perineal disease and to have the IBD‐U phenotype. Among pediatric IBD patients, corticosteroids, mesalamine, and azathioprine were the most commonly used medications, while 25 pediatric patients received biologics.ConclusionThis study provides important information on demography, clinical profile, and treatment practices of IBD in India.

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“…This is also consistent with rising trends observed in other Asian paediatric cohorts in Saudi Arabia[ 16 ], Bahrain[ 17 ], Japan[ 18 ], South Korea[ 19 ] and China[ 20 ]. There still remains a knowledge gap on the epidemiological trends of PIBD in many parts of Asia, particularly Central and South Asian regions, although recently published studies out of Kazakhstan[ 21 ], India[ 22 ] and Nepal[ 23 ] reaffirm IBD as an emerging health issue.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network

Huang¹,

Wong²,

Chew³

et al. 2022

WJG

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BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease (PIBD). AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform. METHODS Clinical, endoscopic and radiologic data at diagnosis from the registry were extracted between 1 st January 1995 to 31 st December 2019. Disease phenotypic characteristics were classified as per the Paris classification system. RESULTS There was a distinct rise in new PIBD cases: Nearly half (48.6%) of the cohort was diagnosed in the most recent 5 years (2015-2019). The ratio of Crohn’s disease (CD):Ulcerative colitis (UC):IBD-Unclassified was 55.9%:38.3%:5.8%. The mean age was 9.07 years with a high proportion of very early onset IBD (VEO-IBD) (29.3%) and EO-IBD (52.7%). An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort (6.8%-9.0% Indians in census). Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease ( P = 0.003). CD patients presented with significantly more constitutional symptoms (fever, anorexia, malaise/fatigue and muscle-wasting) than UC and higher inflammatory indices (higher C-reactive protein and lower albumin levels). CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity. South Asian CD patients were more likely to have symptomatic perianal disease.

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Paediatric inflammatory bowel disease in India: a prospective multicentre study

Cited by 13 publications

References 34 publications

Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020

Inflammatory bowel diseases in Tamil Nadu: A survey of demographics, clinical profile, and practices

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network

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