Paediatric cutaneous adnexal tumours: a study of 559 cases

Ireland, Amanda; Harvey, Nathan T.; Berry, Bligh; Wood, Benjamin A.

doi:10.1016/j.pathol.2016.10.003

Cited by 8 publications

(4 citation statements)

References 17 publications

(29 reference statements)

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“…We also analysed paediatric tumours (in patients aged ≤ 18 years), and found that they accounted for 10% of our caseload. In our paediatric population, the majority of tumours were pilomatrixomas, accounting for 91·7% (155 of 169) of cases in our study, which correlates well with Ireland et al ., who studied paediatric SATs in the same age group and found that 92·5% (517 of 559) were pilomatrixomas 35 …”

Section: Discussionmentioning

confidence: 99%

“…In our paediatric population, the majority of tumours were pilomatrixomas, accounting for 91Á7% (155 of 169) of cases in our study, which correlates well with Ireland et al, who studied paediatric SATs in the same age group and found that 92Á5% (517 of 559) were pilomatrixomas. 35 Prebiopsy diagnosis and the clinical indication communicated to the pathologist on the histology sample submission form was assessed (in the context of SATs, clinical discrimination is recognized to be challenging but has not been studied at scale). In a smaller study (n = 65 cases), 36Á4% of SATs were clinically unsuspected 9 and in another study (n = 528 cases) the clinical diagnosis was unsuspected in 51% of cases.…”

Section: Discussionmentioning

confidence: 99%

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A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

Cook

Bajwa

Hollestein

et al. 2022

British Journal of Dermatology

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Background Skin adnexal tumours (SATs) comprise a diverse range of neoplasms, which are difficult to diagnose clinically. They present in paediatric and adult populations, and may be indicative of an underlying genetic syndrome. There is a lack of recent data on the presentation of these tumours in clinical practice in European populations. Objectives To characterize the clinical and pathological features of SATs received at a single tertiary centre over a 5-year period. Methods A retrospective health record audit of SATs received at the Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, during the period November 2012 to October 2017 was performed. Results In total, 107 144 skin cases were received during the audit period. A total of 1615 cases of SATs from 1359 patients were included; 1570 (97Á2%) were benign and 45 (2Á8%) were malignant. Overall, the average age at presentation was 55 years (range 11 months to 97 years) and the male to female ratio was 0Á77 : 1. Sweat gland and hair follicle SATs were most frequently excised; in adults, the most frequent tumour was hidrocystoma, and in children, pilomatrixoma occurred most often. Prebiopsy diagnosis was correct in 28% of cases. Benign SATs are often markers of an associated genetic condition, which warrants improved discrimination of sporadic from genetically related SATs. Conclusions SATs are difficult to diagnose clinically, and clinicopathological correlation may help enhance discrimination of genetically related SATs from sporadic cases. These data have implications for clinical and dermatopathological training provision, the development of reporting standards, and genetic assessment of selected patients.What is already known about this topic?• Skin adnexal tumours (SATs) comprise a diverse range of neoplasms, which arise from the hair follicle, sebaceous and eccrine glands.• Clinical diagnosis is difficult owing to the lack of discriminatory features.• Selected SATs are recognized markers of underlying genetic conditions, but the proportion of these tumours occurring in unselected European populations is not known.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A 5-year retrospective review of skin adnexal tumours received at a tertiary dermatopathology service: implications for linked genetic diagnoses

Cook

Bajwa

Hollestein

et al. 2022

British Journal of Dermatology

View full text Add to dashboard Cite

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“…Engendered malignancy is cogitated as "clear cell hidradenocarcinoma" or "malignant clear cell hidradenoma". The malignant counterpart is an exceptional neoplasm and is characterized by an infiltrative tumour perimeter, cellular atypia and innumerable atypical mitosis [11,12].…”

Section: Distinguishing Diagnosismentioning

confidence: 99%

“…Malignant transformation is infrequent although neoplasm such as clear cell hidradenocarcinoma tend to reappear. Tumefaction undergoing malignant conversion demonstrate an aggressive clinical course, disseminated disease with adjuvant, enhanced mortality [12,13].…”

Section: Therapeutic Optionsmentioning

confidence: 99%