Paediatric atypical teratoid/rhabdoid tumour of the pineal region mimicking a meningioma: a case report and literature review

Tan, Xuan-Yu; Xiao, Mengliang; Jiang, Wei; Cao, Yilin; Qu, Limei; Zhao, Gang

doi:10.1080/02688697.2021.1895971

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…Establishing an accurate histologic diagnosis is critical for effective treatment of these tumors. Aggressive tumor resection is indicated for ATRT and surgery should typically be followed by chemotherapy or radiation [16,17] .…”

Section: Discussionmentioning

confidence: 99%

Atypical Teratoid Rhabdoid Tumor of the Pineal Region in a 33-Month-Old Child: A Case Report

MACIAS GRAGEDA,

Montenegro Salcedo,

Rodríguez Ruiz

et al. 2023

ijirms

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Purpose: The present article describes a patient with an atypical teratoid/rhabdoid tumor of the pineal region and a literature review about this uncommon pathology. Methods: Literature review about Atypical Teratoid Rhabdoid Tumor between March and July of 2023 using 7 databases: Web of Science, Pubmed, Cochrane Library, SCOPUS, Science Direct, Clinical key and Medscape. Clinical features: A 33-month-old patient with an Atypical Teratoid Rhabdoid Tumor (ATRT) of the pineal region presented headache, VI cranial nerve paralysis, bilateral ataxia and loss of sphincters control during 3 months. Intervention: Endoscopic ventriculostomy with biopsy that reported ATRT. Conclusions: Recent statistics show that this tumor has been underdiagnosed throughout the time and evaluation of surgical material by a neuropathologist is required for its correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Atypical Teratoid Rhabdoid Tumor of the Pineal Region in a 33-Month-Old Child: A Case Report

MACIAS GRAGEDA,

Montenegro Salcedo,

Rodríguez Ruiz

et al. 2023

ijirms

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“…As AT/RT occurring in the pineal gland is extremely rare, even in pediatric cases, 3 there are only a few case reports 19,20 . According to a report of Meyers et al, 21 out of 17 cases, one showed the occurrence of tumor in the pineal gland and two from the pineal gland to the dorsal midbrain, which also spread to the cerebellum.…”

Section: Discussionmentioning

confidence: 99%

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Doi

Koike

Yoshida

et al. 2021

Pathology International

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A 31‐year‐old man suffered from headaches and presented at a hospital after the symptom worsened. Obstructive hydrocephalus and a pineal tumor were identified, and he was transferred to our hospital for further investigation and treatment. Cranial computed tomography revealed a hypodense mass lesion on the right of the pineal region, and calcifications and enlargement of the lateral and third cerebral ventricles were also evident. Blood tests were negative for all tumor markers. Laparoscopic biopsy and third‐ventricle fenestration were performed that day as an emergency surgery to treat the obstructive hydrocephalus. Postoperative cranial magnetic resonance imaging revealed a solid tumor that was hypointense on T1‐weighted imaging, hyperintense on T2‐weighted imaging, and heterogeneously enhanced by Gd. Subsequently, the tumor increased in size, and craniotomy and tumorectomy were performed. Histologically, the tumor proliferated as round or short spindle‐shaped cells in a myxoid matrix, forming arrays that surrounded the blood vessels. As a few cells with eosinophilic cytoplasm were also present and immunostaining for INI‐1 was negative, the patient was diagnosed with atypical teratoid/rhabdoid tumor (AT/RT). AT/RT of the pineal region in adults is rare, and herein, we report the morphological characteristics of this case and reviewed the relevant literature.

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“…Germinomas are the most common type of pineal tumor, but all the different histotypes may be present, including choriocarcinomas, teratomas, embryonal carcinomas, yolk sac tumors, and mixed germ cell tumors [ 3 ]. Other tumors, including metastatic cancer spreading to the pineal gland, are exceedingly uncommon [ 4 , 5 , 6 ].…”

Section: Pathological and Molecular Featuresmentioning

confidence: 99%

“…Tumors of the pineal region (PRT) are rare, accounting for less than 1% of all intracranial tumor lesions, and represent a histologically heterogeneous group of tumors, including primary pineal parenchymal tumors, germ cell tumors (GCT), and tumors originating from the adjacent structures, such as choroid plexus tumors, meningiomas, and gliomas [ 3 ]. Lymphomas, atypical teratoid rhabdoid tumor (ATRT), and metastases may also occur in this region, though they are uncommon (see Figure 1 ) [ 4 , 5 , 6 ]. Pineal parenchymal tumors and germ cell tumors together make up more than 70% of all pineal region tumors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Treatment of Pineal Region Tumors in Adults: A EURACAN Overview

Lombardi

Poliani

Manara

et al. 2022

Cancers

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Pineal region tumors are rare intracranial tumors, accounting for less than 1% of all adult intracranial tumor lesions. These lesions represent a histologically heterogeneous group of tumors. Among these tumors, pineal parenchymal tumors and germ cell tumors (GCT) represent the most frequent types of lesions. According to the new WHO 2021 classification, pineal parenchymal tumors include five distinct histotypes: pineocytoma (PC), pineal parenchymal tumors of intermediate differentiation (PPTID), papillary tumor of the pineal region (PTPR), pinealoblastoma (PB), and desmoplastic myxoid tumor of the pineal region, SMARCB1-mutant; GCTs include germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, mixed GCTs. Neuroradiological assessment has a pivotal role in the diagnostic work-up, surgical planning, and follow-up of patients with pineal masses. Surgery can represent the mainstay of treatment, ranging from biopsy to gross total resection, yet pineal region tumors associated with obstructive hydrocephalus may be surgically managed via ventricular internal shunt or endoscopic third ventriculostomy. Radiotherapy remains an essential component of the multidisciplinary treatment approach for most pineal region tumors; however, treatment volumes depend on the histological subtypes, grading, extent of disease, and the combination with chemotherapy. For localized germinoma, the current standard of care is chemotherapy followed by reduced-dose whole ventricular irradiation plus a boost to the primary tumor. For pinealoblastoma patients, postoperative radiation has been associated with higher overall survival. For the other pineal tumors, the role of radiotherapy remains poorly studied and it is usually reserved for aggressive (grade 3) or recurrent tumors. The use of systemic treatments mainly depends on histology and prognostic factors such as residual disease and metastases. For pinealoblastoma patients, chemotherapy protocols are based on various alkylating or platinum-based agents, vincristine, etoposide, cyclophosphamide and are used in association with radiotherapy. About GCTs, their chemosensitivity is well known and is based on cisplatin or carboplatin and may include etoposide, cyclophosphamide, or ifosfamide prior to irradiation. Similar regimens containing platinum derivatives are also used for non-germinomatous GCTs with very encouraging results. However, due to a greater understanding of the biology of the disease’s various molecular subtypes, new agents based on targeted therapy are expected in the future. On behalf of the EURACAN domain 10 group, we reviewed the most important and recent developments in histopathological characteristics, neuro-radiological assessments, and treatments for pineal region tumors.

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Paediatric atypical teratoid/rhabdoid tumour of the pineal region mimicking a meningioma: a case report and literature review

Cited by 3 publications

References 14 publications

Atypical Teratoid Rhabdoid Tumor of the Pineal Region in a 33-Month-Old Child: A Case Report

Atypical Teratoid Rhabdoid Tumor of the Pineal Region in a 33-Month-Old Child: A Case Report

A case of an atypical teratoid/rhabdoid tumor with distinctive histology in the pineal region in an adult patient

Diagnosis and Treatment of Pineal Region Tumors in Adults: A EURACAN Overview

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