Padina tenuis (marine alga) attenuates oxidative stress and streptozotocin-induced type 2 diabetic indices in Wistar albino rats

Al-Araby, Salahuddin Qader; Rahman, Md. Atiar; Chowdhury, Md. A.H.; Das, Rickta Rani; Chowdhury, Tahseen A; Hasan, Choudhury M.; Afroze, Mirola; Hashem, Mohammad Abul; Hajjar, Dina; Alelwani, Walla; Makki, Arwa A.; Haque, Md. Areeful

doi:10.1016/j.sajb.2019.09.007

Cited by 26 publications

(22 citation statements)

References 27 publications

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“…Mice were healthy at the time of acclimatisation in the laboratory environment before the commencement of the toxicity analysis. The study was conducted according to the OECD guidelines and following the described method with little modification [ 16 , 17 ]. Male Swiss albino mice were divided into seven groups, consisting of six animals (n=6) each.…”

Section: Methodsmentioning

confidence: 99%

“…The free radical scavenging activity of AFMV was assessed using stable DPPH (1,1-diphenyl-2-picrylhydrazil) according to the procedure mentioned earlier [ 16 ]. A 3 ml of 0.004% DPPH solution (4 mg DPPH in 100 ml 95% methanol) was dissolved in different concentration of either extract or standard (31.25–500 µg/ml).…”

Section: Methodsmentioning

confidence: 99%

“…The reducing power assay was investigated according to the modified method [ 16 ]. About 1 ml of the test sample or standard at different concentrations level (31.25–500 μg/mL) was mixed with 2.5 ml of phosphate buffer (0.2 M, pH 6.6) and potassium ferricyanide (1% w/v), respectively and incubated for 20 min at 50°C to complete the reaction.…”

Section: Methodsmentioning

confidence: 99%

“…The free radical scavenging activity of AFMV was assessed using stable DPPH (1,1diphenyl-2-picrylhydrazil) according to the procedure mentioned earlier 16…”

Section: Determination Of Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

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Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia leaves (AFMV) through in vitro and in vivo experimental models. The thrombolytic and anti-arthritic effects of AFMV were evaluated by using the clot lysis technique and inhibition of protein denaturation technique, respectively. The anti-nociceptive activity of AFMV was investigated in Swiss Albino mice by acetic acid-induced writhing test and formalin-induced paw licking test. The antioxidant activities of AFMV, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and total reducing power, were also tested. The qualitative phytochemical assays exhibited AFMV contains secondary metabolites such as alkaloid, carbohydrate, flavonoid, tannin, triterpenoids and phenols. In addition, AFMV showed strong antioxidant effects with the highest scavenging activity (IC50 146.61 µg/mL) and reducing power was increased with a dose-dependent manner. AFMV also revealed notable clot lysis effect and substantial anti-arthritic activity at higher doses (500 µg/mL) as compared with the control. The results demonstrated a promising reduction of the number of writhing and duration of paw licking in acetic acid-induced writhing test and formalin-induced paw licking test in a dose-dependent manner, respectively. In conclusion, AFMV provides the scientific basis of its folkloric usage, suggesting it as the vital source of dietary supplement.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The free radical scavenging activity of AFMV was assessed using stable DPPH (1,1diphenyl-2-picrylhydrazil) according to the procedure mentioned earlier 16…”

Section: Determination Of Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

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Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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“…Experimental animals were observed individually during the first 30 min after dosing, periodically for the first 24 min (special attention for the first 4 hr), with special monitoring for possible unusual responses including behavioral changes, allergic syndromes (itching, swelling, skin, and rash), and mortality over the next 72 hr. The median therapeutic effective dose was intervened as one‐tenth of the median lethal dose (LD50 >2.0 g/kg) (Al‐Araby et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Hossen¹,

Reza²,

Amin³

et al. 2021

Food Science & Nutrition

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Blumea lacera is an edible plant with imperative medicinal values. However, the anxiolytic and antidepressant roles of B. lacera have not been well‐explained. Therefore, the current study aims to explore the impending bioactive metabolites and roles of B. lacera methanol leaf extract (Me‐BLL) in attenuating anxiety and depression through several experimental and computer‐aided approaches. The chemical characterization of Me‐BLL was performed through standard phytochemical and GC‐MS analyses. To explore the neuropharmacological insights, Swiss albino mice were treated with Me‐BLL at doses of 200–400 mg/kg, p.o. The anxiolytic effects were observed employing elevated plus maze (EPM), light–dark box (LDB), and hole‐board (HBT) tests, while antidepressant effects were evaluated using forced swimming (FST) and tail suspension tests (TST). Diazepam (1 mg/kg, i.p.) and fluoxetine HCl (20 mg/kg, p.o.) were used as the reference standard. The phytochemical analyses revealed several bioactive metabolites, including higher contents of total phenolics and flavonoids. The EPM and LDB tests demonstrated an increased time spent in open arms and light box, and the HBT showed an increased number of head dipping, indicating the anxiolytic effects of Me‐BLL. The TST and FST revealed a decrease in immobility time, meaning the persuasive antidepressant effects. The antioxidative effects of Me‐BLL have also been observed prominently. Correspondingly, the computer‐aided investigation confirmed several bioactive lead molecules. Specifically, thymol and cuminol revealed potential anxiolytic and antioxidant effects, while stigmast‐5‐en‐3.beta.‐ol and gamma‐sitosterol possessed promising antidepressant effects. Taken these results as a base, the plant has imperative potentials in managing anxiety and depression‐like disorders.

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Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

Chowdhury

Hashem

et al. 2020

Anim Models and Exp Med

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Background: Justicia adhatoda and Ocimum tenuiflorum, locally known as bashok and tulsi, are two ethnomedicinally important herbs that have been using as dietary supplements for several therapeutic applications. This study evaluated the combined effect of both the herbs as an antioxidative and antihyperlipidemic agent.Methods: Antihyperlipidemic effect was assessed in a high-fat diet-induced hyperlipidemic model in Wistar albino rats. The rats were treated orally with extracts of bashok (J adhatoda, 200 mg/kg bw), tulshi (O tenuiflorum, 200 mg/kg bw), and a combination of bashok and tulshi (50:50), as well as with a reference drug, atorvastatin (10 mg/kg/day), with or without high-fat diet for 14 days. The antioxidative effect was studied using established in vitro models. The studies were supported by experimentally testing the effects of the extracts on membrane stabilization and inhibition of protein denaturation. Results:The results showed that the serum lipid profile was significantly decreased in the different treatment groups, with bashok having the greatest effect. Body weights, total serum protein, LDH, and relative liver and adipose tissue weights were markedly restored towards baseline values, the lowest atherogenic index being achieved with the combined extract. The combination treatment significantly enhanced total phenolic content and antioxidative capacity and greatly potentiated membrane stabilization, but inhibition of protein denaturation was not significantly affected. Conclusion:The data demonstrate that a combination of Justicia adhatoda and Ocimum tenuiflorum could be developed as a food supplement with antioxidative and antihyperlipidemic benefits.

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Padina tenuis (marine alga) attenuates oxidative stress and streptozotocin-induced type 2 diabetic indices in Wistar albino rats

Cited by 26 publications

References 27 publications

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer‐aided model

Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

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