Paclitaxel treatment enhances lymphatic metastasis of B16F10 melanoma cells via CCL21/CCR7 axis

Zhang, Li; Zhu, Linyu; Yao, Xiaohan; Lou, Xiaohan; Wan, Jiajia; Duan, Xixi; Pan, Longze; Li, Anqi; Gu, Zhuoyu; Wang, Ming; Wang, Fazhan; Qin, Zhihai

doi:10.7150/ijbs.67138

Cited by 9 publications

(9 citation statements)

References 47 publications

(62 reference statements)

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“…In this report, we demonstrated that inhibition of miR‐590‐5p observably reversed the inhibitory effect of MOE. In addition, it also been reported that CCR7 is associated with immune responses 49,50 . In our data, CCR7 as a target of miR‐590‐5p and overexpression of CCR7 also remarkably reversed the inhibitory effect of MOE.…”

Section: Discussionsupporting

confidence: 80%

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Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR‐590‐5p/CCR7 axis

Zhao

Zhang

et al. 2023

J of Cosmetic Dermatology

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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with a genetic predisposition, and the traditional Chinese medicine Morinda officinalis and its roots are characterized with anti‐inflammatory effects and have been used for the treatment of various disease. However, it is still largely unknown whether Morinda officinalis extract (MOE) can be used for the treatment of AD. Objectives In our study we aimed to determine whether MOE could ameliorate 2,4‐dinitrochlorobenzene (DNCB)‐induced AD and elucidate molecular mechanisms. Methods We established an AD mouse model by using DNCB. Skin pathological analysis and ELISA assay were used to detect the effect of MOE on the inflammation of AD model mouse skin and the expression changes of inflammatory factors, and further functional verification was performed in TNF‐α/IFN‐γ‐induced HaCaT cells. Results Our in vivo experiments confirmed that MOE remarkably reduced DNCB‐induced AD lesions and symptoms, such as epidermal and dermal thickness and mast cell infiltration and inflammatory cytokines secretion in the mice models. In addition, the underlying mechanisms by which MOE ameliorated AD had been uncovered, and we verified that MOE inhibited MALAT1 expression in AD, resulting in attenuated expression of C‐C chemokine receptor type 7 (CCR7) regulated by MALAT1‐sponge miR‐590‐5p in a competing endogenous RNA (ceRNA) mechanisms‐dependent manner, thereby inhibiting TNF‐α/IFN‐γ‐induced cellular proliferation and inflammation.

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Section: Discussionsupporting

confidence: 80%

“…In addition, it also been reported that CCR7 is associated with immune responses. 49,50 In our data, CCR7 as a target of miR-590-5p and overexpression of CCR7 also remarkably reversed the inhibitory effect of MOE. Therefore, our results…”

Section: Discussionsupporting

confidence: 64%

Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR‐590‐5p/CCR7 axis

Zhao

Zhang

et al. 2023

J of Cosmetic Dermatology

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“…Decreased survival associated with the activation of CCR7 is achieved through PI3K/Akt, ERK1/2, JNK and p38 signalling (Figure 2). 107,108 In addition, a previous study, investigating the expression of CCL21 by B16 F10 melanoma cells documented the elevated infiltration of TREG cells and myeloid‐derived suppressor cells into tumours and found that CCL21 may be a driver of lymphoid neogenesis and immunosuppression, resulting in melanoma cell proliferation 109 …”

Section: The Ccr7/ccl21 Axismentioning

confidence: 96%

Chemokines as possible therapeutic targets in metastatic melanoma

et al. 2023

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Background Cutaneous melanoma is a relentless form of cancer which continues to rise in incidence. Currently, cutaneous melanoma is the leading cause of skin cancer‐related mortality, which can mainly be attributed to its metastatic potential. The activation of chemokine axes is a major contributor to melanoma metastasis through its involvement in promoting tumour cell migration, proliferation, survival, and adhesion. This review will focus on the role of chemokines in melanoma and possible therapeutic strategies to alter chemokine activation and subsequently inhibit the activation of signalling cascades that may promote metastasis. Methods A literature review was conducted to evaluate chemokines as possible therapeutic targets in metastatic melanoma. Results The crosstalk between signalling pathways and immune responses in the melanoma microenvironment resembles a complex and dynamic system. Therefore, the involvement of governing chemokine axes in the promotion of cutaneous and metastatic melanoma demands a proper understanding of the tumour microenvironment in order to identify possible targets and develop appropriate treatments against melanoma. Conclusion Even though chemokine axes are regarded as promising therapeutic targets, it has become increasingly evident that chemokines can play a critical role in both tumour inhibition and promotion. The inhibition of chemokine axes to inhibit signalling cascades in target cells that regulate metastasis should, therefore, be carefully approached.

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“…This suggests that the effect of VEGF-C-enhanced antitumor immunotherapy is somewhat dependent on the CCL21/CCR7 axis. On the other hand, certain CCR7-expressing tumor cells can also use this to undergo lymphatic metastasis, leading to tumor spread and metastasis [202]. Ding et al found an association between high CCR7 expression and lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma [203].…”

Section: Dual Role Of Cerebral Lymphatic System In Brain Metastasis F...mentioning

confidence: 99%

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Zhao¹,

Sun²,

Zhang³

et al. 2024

Aging and disease

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As a recently discovered waste removal system in the brain, cerebral lymphatic system is thought to play an important role in regulating the homeostasis of the central nervous system. Currently, more and more attention is being focused on the cerebral lymphatic system. Further understanding of the structural and functional characteristics of cerebral lymphatic system is essential to better understand the pathogenesis of diseases and to explore therapeutic approaches. In this review, we summarize the structural components and functional characteristics of cerebral lymphatic system. More importantly, it is closely associated with peripheral system diseases in the gastrointestinal tract, liver, and kidney. However, there is still a gap in the study of the cerebral lymphatic system. However, we believe that it is a critical mediator of the interactions between the central nervous system and the peripheral system.

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Paclitaxel treatment enhances lymphatic metastasis of B16F10 melanoma cells via CCL21/CCR7 axis

Cited by 9 publications

References 47 publications

Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR‐590‐5p/CCR7 axis

Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR‐590‐5p/CCR7 axis

Chemokines as possible therapeutic targets in metastatic melanoma

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

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