Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: Formulation, optimization and in vitro characterization

Zhang, Wei; Hao, Junguo; Shi, Yuan; Li, Yajuan; Wu, Juan; Sha, Xianyi; Fang, Xiaoling

doi:10.1016/j.ijpharm.2009.04.030

Cited by 372 publications

(214 citation statements)

References 52 publications

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“…24, and T1107 and T1307 with HLB 18-23) and a medium hydrophilic variety (T904 with HLB 12-18) of poloxamine and their combinations to form single or mixed polymeric micelles as a nanotechnology platform suitable for encapsulation of the CAI-drug ETOX towards the topical treatment of glaucoma. Previous studies showed that to produce mixed poloxamer/poloxamer polymeric micelles both copolymers need to present two main features: (i) hydrophobic blocks of similar molecular weight and (ii) different hydrophilic/hydrophobic balance [33,34]. These two premises were taken into account when choosing the poloxamine varieties included in the study.…”

Section: Self-aggregation Of Poloxaminesmentioning

confidence: 99%

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Ribeiro

Sosnik

Chiappetta

et al. 2012

J. R. Soc. Interface.

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Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g -1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) . T1107 ffi T1307 . T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.

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Section: Self-aggregation Of Poloxaminesmentioning

confidence: 99%

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Ribeiro

Sosnik

Chiappetta

et al. 2012

J. R. Soc. Interface.

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“…In studies by Chaibundit et al [11] it was observed that binary mixtures of Pluronics  , which have the same hydrophobic block length, formed stables comicelles in diluted aqueous solution, and these mixtures showed a single narrow distribution and small particles at room and body temperature [10,11] . In studies by Wei et al [12] this behavior was observed for the mixtures between P123 and F127 solubilizing the drug Paclitaxel. These micelles showed hydrodynamic diameter (D H ) ranging from 20 to 30 nm and polydispersivity index between 0.14 and 0.23.…”

Section: Micelle Sizementioning

confidence: 83%

“…Copolymers used as solubilizing agents should be mostly micellized in dilute aqueous solution. Low CMC values of surfactants are interesting for drug solubilisation because they provide high stability of their micelles in solutions upon dilution in the blood [7,12,18,19] . Figure 2b shows CMC values of P123, F127 and their mixtures at 25 and 37 °C.…”

Section: Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

“…Generally, so that the efficiency of the encapsulated active be long during its circulation in blood, the micelles should be small enough to evade detection and destruction by the reticular endothelial system [12] . In studies by Chaibundit et al [11] it was observed that binary mixtures of Pluronics  , which have the same hydrophobic block length, formed stables comicelles in diluted aqueous solution, and these mixtures showed a single narrow distribution and small particles at room and body temperature [10,11] .…”

Section: Micelle Sizementioning

confidence: 99%

“…Due to their small particle size (<100 nm) these systems exhibit many advantages such as targeting ability, long circulation time and easy production on effective delivery of drugs. Incorporation of low molecular mass drugs into Pluronic  micelles can increase their solubility and stability and improve their pharmacokinetics and biodistribution [7][8][9][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

et al. 2015

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Sbstract Pluronics molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics  have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (S cp ). In this work we studied Pluronics  binary mixture, P123 and F127, as nanocarriers of the hydrophobic drug griseofulvin. P123 (E 21 P 67 E 21 ) shows a relative good S cp , whereas F127 (E 98 P 67 E 98 ) shows a good colloidal stability. According to data, these binary mixtures form stables nano-sized comicelles in aqueous solution. The S cp of the P123/F127 systems at 25 and 37 °C was monitored by UV/Visible spectroscopy, showing good results at both temperatures, as would be expected, since P123/F127 have similar length hydrophobic block. Hydrophobic-dependence and temperature-responsive of the systems were evaluated by CMC, particle size and colloidal stability. Hence, stables P123/F127 comicelles may have potencial as hydrophobic drug delivery.

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Ultrasound Cavitation as a Green Processing Technique in the Design and Manufacture of Pharmaceutical Nanoemulsions in Drug Delivery System

Tang¹,

Tan

Manickam³

2011

Green Chemistry for Environmental Remediation

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Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: Formulation, optimization and in vitro characterization

Cited by 372 publications

References 52 publications

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

Ultrasound Cavitation as a Green Processing Technique in the Design and Manufacture of Pharmaceutical Nanoemulsions in Drug Delivery System

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