Paclitaxel-loaded PLA/PEG/fluorescein anticancer agent prepared by Ugi reaction

Icart, Luis Peña; Santos, Emanuel; Agüero, Lissette; Andrade, Leonardo R.; Souza, Cristiane Gimenes de; d´Avila, Luiz Antonio; Zaldívar, Dionisio; Dias, Marcos L.

doi:10.1080/00914037.2017.1378884

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…Two different fluorescent block copolymers of PLA and PEG containing grafted fluorescein were synthesized. Plaxitel-loaded fluorescent microspheres were prepared from the grafted copolymers, and they proved to have anticancer activity against the colorectal cancer cell line Caco-2 [61].…”

Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…In addition to random copolymers, Ugi reactions have also been used for the fabrication of block copolymers. For example, a fluorescent diblock copolymer with poly(lactic acid) and PEG as hydrophobic and hydrophilic chains was synthesized and applied for the preparation of spheric microparticles 60 . The microspheres were used for the encapsulation of hydrophobic drugs via a single‐emulsion solvent evaporation method.…”

Section: Polymers From Multicomponent Polymerizations and Their Self‐...mentioning

confidence: 99%

“…For example, a fluorescent diblock copolymer with poly(lactic acid) and PEG as hydrophobic and hydrophilic chains was synthesized and applied for the preparation of spheric microparticles. 60 The microspheres were used for the encapsulation of hydrophobic drugs via a single-emulsion solvent evaporation method. This nanocarrier exhibited prolonged and controlled drug release profiles, exhibiting a good inhibition activity to cancer cell growth and colony formation.…”

Section: Polymers From Ugi Reactionmentioning

confidence: 99%

Self‐assembly of polymers from multicomponent reactions

Liu

Kanjilal

Thayumanavan

2022

Polymer International

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Supramolecular assemblies from synthetic polymers have been widely used in materials science and biological applications. Developing convenient and efficient methods to tune polymer structures and architectures is important for achieving desired self‐assembly behaviors. Among various synthetic strategies, multicomponent reactions have drawn significant interest due to the high reaction efficiency, chemical selectivity, atom economy and one‐pot manner. These features make it convenient to manipulate polymer properties by varying chemical building blocks. In this review, we summarize the recent advances in the self‐assembly of polymers from multicomponent reactions. We discuss how multicomponent reactions are applied for polymerization and post‐polymerization modifications, generating polymers with specific self‐assembly behaviors for various research and application purposes. Challenges and perspectives about the development of this field are also discussed. © 2021 Society of Industrial Chemistry.

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Poly(Butylene Succinate) Molar Mass Calculation by GPC and 1H‐NMR

Costa

Santos

Souza

2021

Macromolecular Symposia

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The determination of the molar mass of a polymer is a fundamental characterization. One of the most common techniques used for this purpose is gel permeation chromatography (GPC). However, the most used columns are not appropriate for low molar mass polymers, presenting results that are different from reality. For these cases, it is possible to use the nuclear magnetic resonance (NMR) technique to obtain molar mass values (based on calculations associated with spectra signals and the quantity of the polymer used in the analysis). However, in some cases, the resultant signals of different chain portions can be presented in the same spectral region, hampering calculations. Thus, this paper proposes the use of an external standard. This way, it can correlate to the molar mass of four different samples of poly(butylene succinate) (PBS) with different molar mass values. The results based on NMR spectra were different from those found using GPC, but both increased in the same proportion (R² = 0.8828). Since NMR presents an absolute result, it seems to be the most accurate result. This analysis method also allows us to quantify the experimental percentage of unsaturation, which was lower than the theoretical one due to losses during the PBS synthesis.

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Paclitaxel-loaded PLA/PEG/fluorescein anticancer agent prepared by Ugi reaction

Cited by 3 publications

References 55 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Self‐assembly of polymers from multicomponent reactions

Poly(Butylene Succinate) Molar Mass Calculation by GPC and 1H‐NMR

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