Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells

Watanabe, Kenji; Nishio, Yu; Makiura, Rie; Nakahira, Atsushi; Kojima, Chie

doi:10.1016/j.ijpharm.2013.02.002

Cited by 58 publications

(36 citation statements)

References 22 publications

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“…But, Fe@HAP-PEI-CD showed more potential for CUR loading (CLC= 18% and CLE= 76.6%) in comparison to Fe@PEI-CD that could be related to the presence of inner HAP layer as a porous material 72 . But, Fe@HAP-PEI-CD showed more potential for CUR loading (CLC= 18% and CLE= 76.6%) in comparison to Fe@PEI-CD that could be related to the presence of inner HAP layer as a porous material 72 .…”

Section: Cur Loading Into the CD Modified Mnpsmentioning

confidence: 89%

Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

et al. 2015

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Biocompatible multi-layer iron oxide magnetic nanoparticles (MNPs) for drug delivery applications with increased loading capacity, sustained sensitive release profile, and high inherent magnetic properties as well as improved cellular uptake were prepared. In this approach, Fe 3 O 4 MNPs were obtained by co precipitation method and functionalized using hydroxyapatite (HAP) and/or polyethyleneimine (PEI). They were then modified by βcyclodextrin (CD) to increase loading capacity. These MNPs allowed suitable encapsulation of hydrophobic curcumin (CUR) in CD shell and CUR adsorption into the polymeric layers.The dissolution profile of CUR showed pH sensitive release of CUR. Protein corona pattern of MNPs by electrophoresis showed lower protein adsorption for CD modified MNPs than other MNPs. No significant toxicity was observed for the target MNPs, while the CUR loaded MNPs inhibited MCF-7 breast cancer cells more efficient than free CUR. Also, negligible hemolytic activity of the target MNPs showed their excellent haemocompatibility for cancer treatment. The preferential uptake of drug was resulted in CUR loaded MNPs by MCF-7 cells in comparison with free CUR using flow cytometeric analysis. As a result, the designed and prepared MNPs can be considered as a promising CUR delivery platforms.

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Section: Cur Loading Into the CD Modified Mnpsmentioning

confidence: 89%

Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

et al. 2015

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“…Each strand of the helix consists of a repetitive amino acid sequence, glycine–X–Y, where X and Y are frequently proline (Pro) and hydroxyproline (Hyp) . Due to their excellent gel‐forming ability and biodegradability, collagens have been widely used as biomedical materials for the delivery of chemotherapeutic drugs such as paclitaxel, doxorubicin, and antibacterial drugs such as gentamicin, as well as for tissue support and regeneration applications including skin replacement, bone substitutes, and artificial blood vessels . However, some of the limitations of animal‐derived collagens, such as their thermal instability, possible contamination with pathogenic substances, and relative difficulty in the introduction of specific sequence modifications, have limited their versatility.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Self‐Assembly of Nanostructures from a Collagen‐Like Peptide‐Containing Diblock Copolymer

Luo

He²,

Théato³

et al. 2014

Macromolecular Bioscience

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Temperature-triggered formation of nanostructures with distinct biological activity offers opportunities in selective modification of matrices and in drug delivery. Toward these ends, diblock polymers comprising poly(diethylene glycol methyl ether methacrylate) (PDEGMEMA) conjugated to a triple helix-forming collagen-like peptide (CLP) is produced. The ability of the CLP domain to maintain its triple helix conformation after conjugation with the polymer is confirmed via circular dichroism (CD). Dynamic light scattering (DLS) measurements suggest the diblock conjugate undergo a reversible temperature-induced transition in aqueous solution to form nanoparticles with a diameter of approximately 100 nm, with a transition temperature of 37 °C. Transmission electron microscopy (TEM) suggests the formation of well-defined vesicles above the transition temperature, while no supramolecular assemblies are observed at room temperature. The self-assembly of PDEGMEMA-CLP diblock is triggered by the collapse of the thermoresponsive domain above its LCST. The incorporation of CLP domains in these nanostructures may offer opportunities for the selective targeting of collagen-containing matrices.

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“…Na oncologia, diversos estudos são realizados com o uso de biomateriais nanoestruturado de fosfatos de cálcio em tratamento de tumores na estrutura óssea. Os resultados mostram que esses biomateriais apresentam comportamento eficiente na entrega de fármacos in situ [14][15][16][17].…”

Section: Introductionunclassified

Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

et al. 2019

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RESUMO As biocerâmicas bifásicas hidroxiapatita/fosfato tricálcico-beta (HA/TCP-β) microporosas são pesquisadas e se destacam em aplicações biomédicas como substitutos dos tecidos ósseos. Estes biomateriais são biocompatíveis e apresentam microestruturas microporosas interconectadas, que permitem sua utilização no reparo do tecido ósseo. Devido às suas características microestruturais, estes biomateriais vem sendo também avaliados para liberação controlada de fármacos. O presente trabalho teve como objetivo a incorporação do fármaco carboplatina no biomaterial granulado bifásico microporoso 60%HA/40%TCP-β pelo método de alto vácuo e caracterização do biomaterial carregado, nas concentrações de 1, 5, 10 e 20 mg/g de carboplatina no biomaterial. Os resultados apresentados envolvem a caracterização morfológica, microestrutural, cristalográfica e química do biomaterial granulado bifásico microporoso. A microscopia eletrônica de varredura (MEV) mostrou em suas micrografias a presença dos precipitados de carboplatina na microestrutura microporosa do biomaterial. O resultado da difratometria de raios X (DRX) permitiu a identificação dos picos representativos da fase cristalina da HA, TCP-β e da carboplatina depois do carregamento. A análise por espectroscopia na região do infravermelho (FTIR) evidenciou os modos vibracionais relativos aos fosfatos de cálcio, OH-e PO43-e também Pt-N e NH3 da molécula da carboplatina. Os resultados obtidos demonstraram que a microporosidade da biocerâmica e o método de alto vácuo possibilitaram o carregamento da carboplatina na microestrutura do biomaterial granulado.

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Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells

Cited by 58 publications

References 22 publications

Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

Thermoresponsive Self‐Assembly of Nanostructures from a Collagen‐Like Peptide‐Containing Diblock Copolymer

Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

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