Paclitaxel loaded carrier based biodegradable polymeric implants: Preparation and in vitro characterization

Abstract

The objective of this study was to develop paclitaxel (PTX) loaded poly(ε-caprolactone) (PCL) based tiny implants. β-Cyclodextrin (β-CD) and polyethylene glycol (PEG 6000) were used to enhance solubility and release of the drug in the phosphate buffer saline pH 7.4. Implants were evaluated in terms of color, shape, thickness, surface area, weight, drug content. Developed implants were characterized for their surface morphology (SEM analysis), drug physical state by thermal analysis (DSC studies), crystalline nature (XRD studies) and drug excipients compatibility (FT-IR spectroscopy). Macroscopically all the tiny implants were white in color and cylindrical in shape with smooth surfaces. PTX was entrapped within implants in the polymeric amorphous form. In vitro drug release studies showed prolonged and controlled release of PTX with zero order and Korsmeyer-Peppas model being exhibited. Excipients and method of preparation did not affect chemical stability of PTX.

Improved catalytic activity by catalase immobilization using γ‐cyclodextrin and electrospun PCL nanofibers

“…For instance, peak shifts were recorded in all encapsulations (catalase‐γCD complex encapsulation into PCL nanofiber, catalaze‐γCD physical mixture encapsulation into PCL nanofibers and catalase encapsulation into PCL nanofibers) at pure PCL peak values of 3444, 2948, 1294, and 1240 cm −1 in the FT‐IR spectrum. The adsorption band at 3444 cm −1 corresponds to OH vibrations, 2948 cm −1 corresponds to CH stretching, 1294 cm −1 corresponds to CO and CC stretching and the peak at 1240 cm −1 corresponds to antisymmetrical COC stretching vibrations …”

Creation of a functional graded nanobiomembrane using a new electrospinning system for drug release control and an in vitro validation of drug release behavior of the coating membrane

“…The characteristic peaks of PCL nanofibers were observed at 1730 cm −1 , 732 cm −1 , 840-1470 cm − 1 , 2892 cm − 1 , and 2930 cm − 1 . PTX loaded PCL-PF showed peaks at 2948 cm −1 and 1729 cm − 1 for C\H sp3 and C_O stretch, respectively; drug peaks were disappeared in composite fibers, may be due to drug was completely entrapped in the polymer fibers or polymeric amorphous surface since their concentration is also much less [29]. Results of FT-IR studies revealed no evidence of chemical interaction of drug with polymers.…”

Small-angle neutron scattering studies of microenvironmental and structural changes of Pluronic micelles upon encapsulation of paclitaxel

“…1, the structure of PTX offers a variety of functional groups to form bonds with P123. FTIR spectra of the samples loaded with PTX showed additional peaks of PTX molecule at 1,072, 1,248, 1,370, and 2,965 12 cm −1 that were assigned to C-O stretch, C-N stretch, CH 3 bending, and =C-H structure, respectively [33,34]. However, resonance intensities and morphologies varied between samples.…”