Paclitaxel Inhibits Proliferation of Cell Lines Responsible for Metal Stent Obstruction:

Kalinowski, Marc; Alfke, Heiko; Kleb, Beate; Dürfeld, Frank; Wagner, H

doi:10.1097/00004424-200207000-00007

Cited by 59 publications

(33 citation statements)

References 26 publications

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“…1 Paclitaxel, a chemotherapeutic agent that has been shown to inhibit cell proliferation in fibroblasts, pancreatic cancer, and epithelial cells in the gallbladder, has been studied for its effect on patency. 33 Suk et al investigated Niti-S Mira-Cover stents coated with paclitaxel. They inserted 21 stents in patients diagnosed with unresectable malignant biliary obstruction.…”

Section: Drug-eluting Stentsmentioning

confidence: 99%

An Update to Hepatobiliary Stents

Moy¹,

Bir²

2015

JCTH

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Endoscopic stent placement is a common primary management therapy for benign and malignant biliary strictures. However, continuous use of stents is limited by occlusion and migration. Stent technology has evolved significantly over the past two decades to reduce these problems. The purpose of this article is to review current guidelines in managing malignant and benign biliary obstructions, current endoscopic techniques for stent placement, and emerging stent technology. What began as a simple plastic stent technology has evolved significantly to include uncovered, partially covered, and fully covered self-expanding metal stents (SEMS) as well as magnetic, bioabsorbable, drug-eluting, and antireflux stents.

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Section: Drug-eluting Stentsmentioning

confidence: 99%

An Update to Hepatobiliary Stents

Moy¹,

Bir²

2015

JCTH

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“…36 In vitro and in vivo studies (the latter using drug-coated SEMSs) have demonstrated that local exposure to paclitaxel, 5-fluorouracil, and gemcitabine can induce local responses when placed in contact with both benign and malignant GI tract tissues. [37][38][39][40][41][42][43][44] To date, there are only a few small published case series in humans. These demonstrated that partial responses in unresectable cholangiocarcinoma can be achieved with a carboplatincoated percutaneous biliary tube, 45 and endoscopically placed drug-eluting SEMS may be associated with improved stent patency and overall survival in patients with extrahepatic cholangiocarcinoma.…”

Section: Drug-eluting Stents In the Gi Tractmentioning

confidence: 99%

Drug-eluting/biodegradable stents

Tokar¹,

Banerjee²,

Barth

et al. 2011

Gastrointestinal Endoscopy

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“…Anti-tumor agents are usually delivered by simple diffusion, into the mucosal and submucosal layers. The recently introduced paclitaxel-eluting covered metal stents may prevent occlusion from tumor ingrowth by the anti-tumor effect of paclitaxel [31]. These stents were reported to be safe and effective in animal and human studies [32,33].…”

Section: Update In Palliation Of Biliary Tumorsmentioning

confidence: 99%

Update in Biliary Endoscopy

Costamagna¹,

Boškoski²,

Familiari³

et al. 2011

Dig Dis

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Biliary endoscopy has seen the development of several new techniques in the last few years. Its current role includes direct diagnostic imaging, tissue sampling, early diagnosis and palliation of biliary tumors. Relatively new methods for biliary stones management are electrohydraulic lithotripsy combined with choledochoscope guidance and laser lithotripsy. Intraductal ultrasound, confocal laser endomicroscopy and optical coherence tomography are emerging, purely diagnostic endoscopic tools in biliary endoscopy. Cytological examinations such as digital imaging analysis and fluorescence in situ hybridization have the potential of becoming very important in the early diagnosis of biliary tumors. Direct visualization of the biliary mucosa and tissue sampling can be done with the last generation of cholangioscopes. All these tools are promising, especially for the ‘undetermined biliary strictures’. Improvements in quality of life, survival and biliary drainage in patients with non-operable cholangiocarcinoma have been reported after the application of both photodynamic therapy and high-dose rate intraluminal brachytherapy. Drug-eluting stents with incorporated anti-tumor agents designed to improve patency and reduce the risk of tumor ingrowth have already been tested, and other stents are under investigation as well.

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Paclitaxel Inhibits Proliferation of Cell Lines Responsible for Metal Stent Obstruction:

Cited by 59 publications

References 26 publications

An Update to Hepatobiliary Stents

An Update to Hepatobiliary Stents

Drug-eluting/biodegradable stents

Update in Biliary Endoscopy

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