Paclitaxel in Combination with Coumarin as a Potentially Effective Anticancer Agent

Zobel, A.M.; Schellenberger, S.E.

doi:10.1076/1388-0209(200007)38:3;1-s;ft192

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Supuran and his group have reported that some of the coumarinylsubstituted benzenesulfonamide series are potent, low nanomolar CA-V inhibitors [26]. In another study, Zobel et al demonstrated the enhanced anticarcinogenic potential of combining coumarin at high concentrations (greater than 10 ppm) with the chemotherapy agent, Paclitaxel [32].…”

Section: Resultsmentioning

confidence: 97%

In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

Başaran

Sinan

Çakır

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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Section: Resultsmentioning

confidence: 97%

In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

Başaran

Sinan

Çakır

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Zobel and Schellenberger suggested that paclitaxel can be used in combination with other natural products such as coumarins for the inhibition of mitosis. 2 Coumarins are extruded to the surface of many medicinal plants 3 and can cause phytophotodermatitis if psoralens rubbed on the skin are exposed to ultraviolet radiation, either artificial or in sunlight. 4 We have found several interesting taxoids among them paclitaxel, on the surface of Taxus leaves, each potentially toxic.…”

Section: Introductionmentioning

confidence: 99%

Influence of water extracts from the surface of two Yew (Taxus) species on mites (Tetranychus urticae)

Furmanowa

Kropczynska²,

Zobel

et al. 2002

J of Applied Toxicology

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Taxus cuspidata and Taxus media var. Hicksii contain paclitaxel, among other taxoids, on the surface of the needles. These compounds were removed by 5-s dipping of the needles in water just below its boiling point at 96 degrees C and at 60 degrees C and 40 degrees C. Taxus cuspidata contained a fourfold higher concentration of paclitaxel than Taxus media var. Hicksii. The extract with the higher concentration of paclitaxel was more harmful to the mites Tetranychus urticae Koch, increasing their mortality 150%, prolonging development by ca. 20% and lowering the average fecundity from 112 in the control to 16.13 after treatment with Taxus cuspidata; also, the net reproductive rate dropped from 70.24 to 6.70, which is more than a tenfold reduction.

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Paclitaxel in Combination with Coumarin as a Potentially Effective Anticancer Agent

Abstract: ABSTRACT

Cited by 2 publications

References 8 publications

In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

Influence of water extracts from the surface of two Yew (Taxus) species on mites (Tetranychus urticae)

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