Packing materials for enantioselective preparative chromatography

Chiral Stationary Phases for Preparative Enantioselective Chromatography

“…For the same reason, only a limited number of materials can be reasonably applied for preparative purposes among the broad range of available CSPs that have been developed for analytical separation of enantiomers. The estimated loading capacity of the most commonly used phases has already been previously discussed [3,24,[79][80][81]118,119]. However, it must be emphasised that the optimal CSP in terms of loading capacity may vary from one racemate to another, depending on the structure of the racemic compound to be resolved, as it is a function of the number of accessible interaction sites per mass unit of the phase.…”

Techniques in Preparative Chiral Separations

“…Therefore, some types of CSPs are more suitable than others for preparative purposes [21,25]. Scale-up of a chiral separation can be made having as a reference an analytical resolution, but optimization of the preparative process is critically dependent upon the nature of the CSP.…”