Packed column supercritical fluid chromatography of a peroxysome proliferator-activating receptor agonist drug

Gyllenhaal, Olle

doi:10.1016/j.chroma.2004.05.035

Cited by 25 publications

(10 citation statements)

References 20 publications

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“…In addition, injections of 0. Gyllenhaal [29] described the achiral and chiral purity determination of a peroxysome proliferators-activating receptor agonist. Since our review only focuses on chiral separations, we will only discuss these.…”

Section: Separations On Polysaccharide-based Cspmentioning

confidence: 99%

Chiral separations in sub‐ and supercritical fluid chromatography

Mangelings

Heyden²

2008

J of Separation Science

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Section: Separations On Polysaccharide-based Cspmentioning

confidence: 99%

Chiral separations in sub‐ and supercritical fluid chromatography

Mangelings

Heyden²

2008

J of Separation Science

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“…The use of water has long been regarded as detrimental to SFC analysis. However, some recent studies have proven the possibility and beneficial effects of water as sample diluent [22][23][24][25][26]. Water was also investigated in this work as sample diluent with multiple injection as compared to acetonitrile.…”

Section: Multiple Injection Using Water As Sample Diluentmentioning

confidence: 99%

Signal enhancement in supercritical fluid chromatography‐diode‐array detection with multiple injection

Sun

Turner

Sandahl

2019

J of Separation Science

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To circumvent the detrimental effects of large‐volume injection with fixed‐loop injector in modern supercritical fluid chromatography, the feasibility of performing multiple injection was investigated. By accumulating analytes from a certain number of continual small‐volume injections, compounds can be concentrated on the column head, and this leads to signal enhancement compared with a single injection. The signal to noise enhancement of different compounds appeared to be associated with their retention on different stationary phases and with type of sample diluent. The diethylamine column gave the best signal to noise enhancement when acetonitrile was used as sample diluent and the 2‐picolylamine column showed the best overall performance with water as the sample diluent. The advantage of multiple injection over one‐time large‐volume injection was proven with sulfanilamide, with both acetonitrile and water as sample diluents. The multiple injection approach exhibited comparable within‐ and between‐day precision of retention time and peak area with those of single injections. The potential of the multiple injection approach was demonstrated in the analysis of sulfanilamide‐spiked honey extract and diclofenac‐spiked ground water sample. The limitations of this approach were also discussed.

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“…SFC methods developed to be applied in quality control testing are described in several publications [35,44,45]. The finally chosen experimental conditions for these applications are presented in Table 4.…”

Section: Quality Control Testingmentioning

confidence: 99%

“…In [44], a candidate drug (a peroxysome proliferatoractivating -receptor) and/or four related substances were determined using SFC-UV. Four methods were optimized: one to assay the bulk drug substance, one for the drug substance in aqueous solution, one for the enantiomeric purity of the bulk drug substance, and one for the enantiomeric purity of the drug substance in aqueous solution.…”

Section: Quality Control Testingmentioning

confidence: 99%

Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

Dejaegher

Pieters²,

Heyden³

2010

CCHTS

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In this review paper, the high-throughput potential of some novel chromatographic modes is surveyed. The modes are Hydrophilic Interaction Liquid Chromatography (HILIC), Supercritical Fluid Chromatography (SFC), and Polar Organic Solvent Chromatography (POSC). Their high throughput potential will be discussed in three domains, i.e. drug discovery, bio-analysis in clinical drug development, and quality control (QC) testing, and is illustrated with some examples.

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Packed column supercritical fluid chromatography of a peroxysome proliferator-activating receptor agonist drug

Cited by 25 publications

References 20 publications

Chiral separations in sub‐ and supercritical fluid chromatography

Chiral separations in sub‐ and supercritical fluid chromatography

Signal enhancement in supercritical fluid chromatography‐diode‐array detection with multiple injection

Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

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