Packaging of surface acoustic wave (SAW) based biosensors: an important issue for future biomedical applications

Länge, Kerstin; Blaess, Guido; Volgt, A.; Rapp, M.; Hansjosten, E.; Schygulla, U.

doi:10.1109/freq.2004.1418473

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…The SAW devices can be structured using photolithography which allows to integrate a high number of sensors on a small area. Devices with fluidic volumes well below 1 µL have been developed [ 36 ]. SAW sensors have the highest theoretical mass sensitivity among the acoustic resonators [ 37 ] and with a shown limit of detection of lower than 0.08 ng/cm 2 [ 38 ], a robust sensor system based on SAW would be extremely competitive to existing commercially available technology.…”

Section: Transducer Principlesmentioning

confidence: 99%

Review of Transducer Principles for Label-Free Biomolecular Interaction Analysis

2011

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Label-free biomolecular interaction analysis is an important technique to study the chemical binding between e.g., protein and protein or protein and small molecule in real-time. The parameters obtained with this technique, such as the affinity, are important for drug development. While the surface plasmon resonance (SPR) instruments are most widely used, new types of sensors are emerging. These developments are generally driven by the need for higher throughput, lower sample consumption or by the need of complimentary information to the SPR data. This review aims to give an overview about a wide range of sensor transducers, the working principles and the peculiarities of each technology, e.g., concerning the set-up, sensitivity, sensor size or required sample volume. Starting from optical technologies like the SPR and waveguide based sensors, acoustic sensors like the quartz crystal microbalance (QCM) and the film bulk acoustic resonator (FBAR), calorimetric and electrochemical sensors are covered. Technologies long established in the market are presented together with those newly commercially available and with technologies in the early development stage. Finally, the commercially available instruments are summarized together with their sensitivity and the number of sensors usable in parallel and an outlook for potential future developments is given.

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Section: Transducer Principlesmentioning

confidence: 99%

Review of Transducer Principles for Label-Free Biomolecular Interaction Analysis

2011

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“…In this direction, of late, the performance of these microdevices has improved significantly when integrated with the alternative forms of energy alongside the incorporation of effective nanomaterials. For example, metal or metal-oxide nanoparticles (NPs), , polymeric nanofibers, nanotubes, and carbon allotropes are now integrated with transistors, actuators, − and piezoelectric, flexible electronic, , and microelectro-mechanical systems (MEMS) devices − to improve their selectivity and specificity. Further, the scientific principles associated with the propagation of acoustic waves through diverse solid or fluidic materials and the subsequent change in the materials properties have also been employed for sensing and detection. − At the micro- or nanoscale, the surface acoustic wave (SAW) devices have been successfully employed for the detection of biomolecules, gases, and vapors .…”

Section: Introductionmentioning

confidence: 99%

Acoustic Wave Catalyzed Urea Detection Utilizing a Pulsatile Microdroplet Sensor

Thakur

Bhattacharjee

Dasmahapatra

et al. 2019

ACS Sustainable Chem. Eng.

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We observe variations in the electrical resistance across a conducting water microdroplet when it was placed on a glass substrate before being mechanically vibrated at natural frequency with the help of an acoustic source. The reduction in the resistance across the droplet was magnified owing to the formation of vortices in the matrix when the periodic oscillation of the surface was increased. The variation in the resistance could be tuned with the frequency of the sound source, which was found to be maximum when a 10 μL droplet was vibrated at ∼320 Hz. Interestingly, the variation in resistance across the oscillating droplet could follow and distinguish the musical notes in the octaves (“sur”) or rhythmic cycles (“taal”) originating from musical instruments such as flute, harmonium, whistle, and tabla. Further, when a suspension of urease-stabilized gold–cadmium–sulfide nanocomposite was suspended inside the droplet and mixed with an analyte containing urea solution, the change in the resistance during the operational time period was found to monotonically vary with the concentration of urea in the analyte. The enzymatic reaction between urea and urease was found to follow a faster first-order chemical kinetics than the commonly observed Michaelis–Menten pathway owing to the presence of the moving nanocomposites and mixing vortices under the optimal acoustic excitations. The specific lock-and-key enzymatic reaction helped in extending these experimental results to estimate the unknown levels of urea in human blood serum samples.

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Packaging of surface acoustic wave (SAW) based biosensors: an important issue for future biomedical applications

Cited by 2 publications

References 5 publications

Review of Transducer Principles for Label-Free Biomolecular Interaction Analysis

Review of Transducer Principles for Label-Free Biomolecular Interaction Analysis

Acoustic Wave Catalyzed Urea Detection Utilizing a Pulsatile Microdroplet Sensor

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