Pachymic Acid Ameliorates Pulmonary Hypertension by Regulating Nrf2-Keap1-ARE Pathway

He, Yuan; Zhong, Jianhua; Wei, Xinlei; Huang, Chuying; Peng, Pailan; Yao, Jun; Song, Xiusheng; Fan, Wanli; Li, Guang‐Cai

doi:10.1007/s11596-021-2414-2

Cited by 12 publications

(10 citation statements)

References 29 publications

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“…Pachymic acid is a lanostane-type triterpenoid compound, which is a natural active compound extracted from Poria cocos with potent pharmacological effects such as anti-inflammatory, anti-oxidation and anti-apoptosis [ 201 ]. Numerous studies have shown that persistent or accumulated non-infectious myocardial inflammation is directly related to the development of HF and can be caused by a variety of injuries, including ischemia, hypoxia, hemodynamic overload and chemotherapy stimulation.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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“…Studies have confirmed that activating mitophagy can inhibit apoptosis and inflammatory responses and delay the occurrence and development of diabetes complications. Poricoic acid A (PAA) is a tetracyclic triterpenoid extracted from Poria cocos, It possesses biological activities such as antioxidant, anti-inflammatory, and hypoglycemic properties ( He Y. et al, 2022 ). HG treatment upregulates the protein expression of FUNDC1 in mouse podocytes, promotes FUNDC1-mediated mitophagy, enhances the expression of IL-6 and IL-1β, decreases podocyte viability, proliferation, and mitochondrial MMP levels, increases ROS generation, and accelerates podocyte injury in mice.…”

Section: Mitophagy and Metabolic Diseasesmentioning

confidence: 99%

The role of mitophagy in metabolic diseases and its exercise intervention

Tang,

Geng,

Lin

2024

Front. Physiol.

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Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases that threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases. This article reviews the role of mitophagy in metabolic diseases, the effects of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for future basic and clinical research on exercise interventions to prevent and treat metabolic diseases.

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“…Both cytoplasmic and nuclear Nrf2 expression levels were significantly diminished in PASMCs induced by hypoxia, while hypoxia promoted Keap1 accumulation and PA reversed the dysregulated Nrf2 and Keap1 expression caused by hypoxia in PASMCs. PA treatment also upregulated the decreased Nrf2 downstream gene expression, including HO-1 and SOD-1, and reduced intracellular ROS generation [ 101 ]. The research findings demonstrated that PA might become a potential pH treatment approach.…”

Section: Nrf2 Activators As a Novel Therapeutic Approach For Phmentioning

confidence: 99%

Target Nuclear Factor Erythroid 2-Related Factor 2 in Pulmonary Hypertension: Molecular Insight into Application

Qin

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor involved in maintaining redox balance and activates the expression of downstream antioxidant enzymes. Nrf2 has received wide attention considering its crucial role in oxidative and electrophilic stress. Large amounts of studies have demonstrated the protective role of Nrf2 activation in various pulmonary hypertension (pH) models. Additionally, various kinds of natural phytochemicals acting as Nrf2 activators prevent the development of pH and provide a novel and promising therapeutic insight for the treatment of pH. In the current review, we give a brief introduction of Nrf2 and focus on the role and mechanism of Nrf2 in the pathophysiology of pH and then review the relevant research of Nrf2 agonists in pH in both experimental research and clinical trials.

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Pachymic Acid Ameliorates Pulmonary Hypertension by Regulating Nrf2-Keap1-ARE Pathway

Cited by 12 publications

References 29 publications

The recent advance and prospect of natural source compounds for the treatment of heart failure

The recent advance and prospect of natural source compounds for the treatment of heart failure

The role of mitophagy in metabolic diseases and its exercise intervention

Target Nuclear Factor Erythroid 2-Related Factor 2 in Pulmonary Hypertension: Molecular Insight into Application

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