“… 170 Furthermore, in rats with BLM-induced pulmonary fibrosis, pachymic acid also showed benefits with decreasing the expressions of HYP and TGF-β1, and regulating oxidative indicators (MDA, SOD, CAT, and ROS). 144 Importantly, pachymic acid treatment also could down-regulate the levels of ERS-related proteins (BIP, CHOP, caspase-9, and ATF4). Collectively, pachymic acid may alleviate BLM-induced lung fibrosis and pathological injury in vivo by inhibiting ERS and improving mitochondrial function.…”