Pachymeningeal metastasis from squamous cell carcinoma of the uterine cervix with involvement of the optic nerve: case report and review of the literature

Balaji, Ravikanth; Ramachandran, K.; Kumar, Aswin; Krishnakumar, AS; Venugopal, M

doi:10.1102/1470-7330.2007.0020

Cited by 17 publications

(8 citation statements)

References 12 publications

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“…To the best of our knowledge, there are only 19 cases of this disease reported in the English‐language literature (Table , Fig. ) . A literature review highlighted two unique features of the present case: (1) oculomotor nerve metastasis causing ptosis, and (2) the longest interval (17 years) from primary tumor treatment to the onset of LM.…”

Section: Discussionmentioning

confidence: 74%

Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment

Oike

Ohno

Noda

et al. 2015

Clinical Case Reports

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Section: Discussionmentioning

confidence: 74%

Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment

Oike

Ohno

Noda

et al. 2015

Clinical Case Reports

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“…A few cases have arisen from malignant transformation of epidermoid cyst epithelium within the brain [22,23]. Other reported primary sites giving rise to squamous cell LM include cervix [24][25][26][27][28] and vulva [29]. Although the lung is the commonest source of metastatic squamous cell carcinoma in the Western world, we found few cases of LM from this site.…”

Section: Discussionmentioning

confidence: 82%

Squamous cell carcinomatous meningitis

Karim¹,

Nava

Paal

et al. 2009

Oncol Rev

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A case of leptomeningeal carcinomatosis due to a poorly differentiated malignancy is presented. Immunohistochemistry was used to characterize it as a squamous cell carcinoma. Squamous cell carcinomas rarely invade the meninges. There are few well-founded guidelines for managing patients with this condition. Prognosis is generally poor. A literature review of this entity is provided.A 64-year-old African American man presented to the Otolaryngology Clinic with a 1-month history of a left neck mass. The patient had a history of alcoholic liver cirrhosis with a transjugular intrahepatic portosystemic shunt (TIPS) procedure. He was a tobacco user and had chronic obstructive pulmonary disease. A 1 cm, nontender supraclavicular node was observed. A magnetic resonance imaging (MRI) scan of the neck revealed adenopathy in levels II-V and a mass in the posterior aspect of the left parotid gland, invading both superficial and deep lobes. Fine needle aspiration (FNA) of the mass revealed poorly differentiated carcinoma which was focally positive for pancytokeratin (AE1/AE3) and negative for mucin, CK20 and CK7. Endoscopy revealed no visible lesions in the upper aerodigestive tract or esophagus. An excisional biopsy of the parotid mass revealed metastatic poorly differentiated squamous cell carcinoma that was positive for CK5/6 and P63; and negative for AE1/AE3, CK7, CK20, TTF1, CK8/18, S100, HMB45, MART1, CD45, and CD3. Flow cytometry revealed polyclonal B cells. A computerized tomographic (CT) scan of the chest revealed mediastinal and bilateral axillary adenopathy. A fusion positron emission tomographic (PET) scan/CT scan revealed activity in the neck, mediastinum, and axillae but no other areas of concern. An FNA of a right axillary lymph node revealed poorly differentiated squamous cell carcinoma with an immunohistochemical (IHC) staining pattern identical to that of the neck biopsy. The patient was started on chemotherapy consisting of weekly carboplatin (AUC = 2) and weekly paclitaxel (50 mg/m 2 ). He experienced an immediate hypersensitivity reaction to the first dose of paclitaxel and received gemcitabine 1,000 mg/m 2 every other week in its place thereafter. One week after the first cycle of chemotherapy, the patient was noted to be mildly confused and inappropriate. Some improvement resulted from a decrease in narcotic doses, administered for pain.Prior to his third planned cycle of chemotherapy, he presented to the emergency room for headaches, nausea, vomiting, and photophobia. He was found to be confused and disoriented with tangential speech. He was hemodynamically stable and afebrile. Neurological examination revealed ataxia, but there were no cranial nerve, sensory, or motor deficits. Laboratory values revealed a hematocrit of

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“…ONSM is a rare tumour. In 1614, Felix Plater first described meningioma during an autopsy [14]. In general, it may be either primary or secondary.…”

Section: Discussionmentioning

confidence: 99%

Papilledema as a diagnostic challenge — report of three cases

Cekić

Risimic²,

Stanković-Babić

et al. 2011

Open Medicine

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AbstractWe present three different cases of patients with papilledema: one case with a primary tumour of the optic nerve, and two cases with secondary involvement of the optic nerve (breast carcinoma and non-Hodgkin lymphoma). The visual acuity varies from sudden, painless, decrease of vision, to blurred vision and proptosis on the affected eye. A characteristic ophthalmoscopic examination shows a swollen optic disc and promonence with tortuosity of blood vessels. A fluorescein angiography shows dilated capillaries of the optic disc with leakage in the early phase and diffuse hyperfluorescence during the late phase. A ultrasonography B-scan of the affected eye shows prominent optic nerves with widened optic nerve sheath. An exhaustive history and complete ophthalmological examination are essential for the diagnosis, to which fluorescein angiography, B-scan ultrasonography, ocular coherent tomography, computerized tomography, and magnetic resonance can be used as useful additional tests. Treatment and prognosis depend on the primary process. We emphasize the crucial role of ophthalmologist in the early diagnosis of CNS neoplasia.

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Pachymeningeal metastasis from squamous cell carcinoma of the uterine cervix with involvement of the optic nerve: case report and review of the literature

Cited by 17 publications

References 12 publications

Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment

Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment

Squamous cell carcinomatous meningitis

Papilledema as a diagnostic challenge — report of three cases

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