Pachychoroid disease spectrum: review article

Mazzeo, Thiago José Muniz Machado; Leber, Henrique Monteiro; Silva, Allan Gomes da; Freire, Raimunda Cristina Mendonça; Barbosa, Gabriel Castilho Sandoval; Criado, Guilherme Garcia; Jacob, Gabriel Almeida Veiga; Machado, Cleide Guimarães; Gomes, André Luís

doi:10.1007/s00417-021-05450-3

Cited by 21 publications

(15 citation statements)

References 118 publications

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“…Looking closely at retinal and choroidal morphology in the course of CSCR may provide information on the potential damage caused. Currently, it is accepted that the origin of pathology in CSCR is thickened choroid [8, 9]. Dilation of choroidal large vessels results in pressure on the choriocapillaris.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Significant Visual Impairment after Short-Lasting Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

Pompein-Batkiewicz

2022

Case Rep Ophthalmol

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A 37-year-old man experienced two episodes of central serous chorioretinopathy (CSCR) with the onset within a 7-month period, one in each eye. The diagnosis was made based on spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and fluorescein angiography. The presence of subretinal neovascularization and polypoidal choroidal vasculopathy were excluded. Each CSCR episode lasted for approximately 6 months and resolved completely after laser photocoagulation (left eye) and photodynamic therapy (right eye). In the right eye, subthreshold micropulse laser treatment and oral eplerenone were initially administered because of a verteporfin shortage, but they were not effective. Final best-corrected visual acuity was 0.8 logMAR in the left eye and “counting fingers” in the right. SD-OCT revealed significant retinal thinning in both eyes despite FAF, showing no major loss of retinal pigment epithelial cells. A significant reduction of ganglion cell complex thickness occurred in the right eye. Acute CSCR can result in significant visual impairment, even when short-lasting.

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Section: Discussion/conclusionmentioning

confidence: 99%

Significant Visual Impairment after Short-Lasting Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

Pompein-Batkiewicz

2022

Case Rep Ophthalmol

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“…4 As most patients are asymptomatic, regular monitoring for any progression to symptomatic pachychoroid diseases such as CSC, PNV, and PCV is needed. 25…”

Section: Pachychoroid Pigment Epitheliopathymentioning

confidence: 99%

“…49 Differences in baseline ocular characteristics such as choroidal vascular hyperpermeability and choroidal thickness affect treatment response. 25 Future research to identify clinical and imaging biomarkers may provide guidance on the optimal management for PCV/AT1. 49…”

Section: Polypoidal Choroidal Vasculopathy or Aneurysmal Type 1 Neova...mentioning

confidence: 99%

Advancements in ophthalmic imaging for better understanding of pachychoroid spectrum diseases: perspective

Wong

Lam

Lai

2022

Hong Kong Journal of Ophthalmology

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“…One of the causes of peripapillary SRF and IRF is peripapillary pachychoroid syndrome (PPS). This disease was first reported by Phasukkijwatana et al 2 PPS has been described as part of the pachychoroid disease spectrum, as it shares some clinical signs with other diseases in this group, such as CSC, and may, therefore, share a common pathophysiology 2–4 . Phasukkijwatana and colleagues defined PPS as a peripapillary choroidal thickening with the presence of IRF and/or SRF in the nasal macula.…”

Section: Introductionmentioning

confidence: 99%

NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the Retina: A New Phenotype and its Differential Diagnosis

Sirks,

van Dijk,

Pauleikhoff

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: The presence of peripapillary intraretinal fluid (IRF) has a broad differential diagnosis, including several types of neovascular and pachychoroid-related diseases. However, the clinician may encounter cases without signs of neovascular or pachychoroid disease, or any other previously described diagnosis. For these patients, we propose the term NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the retina, and we discuss the differential diagnosis. Design: A retrospective chart study set in a tertiary referral center for retinal diseases in Amsterdam, the Netherlands. Methods: Using multimodal imaging, cases suspected of peripapillary pachychoroid syndrome were reviewed. Cases without signs of neovascular or pachychoroid disease were included in this study. These cases were discussed in a group of senior retinal specialists to establish a diagnosis, and if there was no evidence for any previously described diagnostic entity, these cases were categorized as NOPPES. Results: Four cases of NOPPES were identified, 3 female patients and 1 male patient, aged between 58 and 75 years. Two patients were myopic, and 1 patient had a mild hyperopia. Three out of 4 cases showed unilateral peripapillary IRF, and 1 case had bilateral IRF. No improvement was seen after intravitreal bevacizumab or aflibercept, nepafenac eye drops, oral acetazolamide, vitrectomy with internal limiting membrane peeling, or surgery for carotid stenosis. One case showed a reduction in IRF after starting prednisolone eye drops. Conclusions: We describe NOPPES, a new form of peripapillary schisis-like IRF. NOPPES seems relatively therapy-resistant. More research is needed to delineate the clinical spectrum of NOPPES and its pathogenesis and treatment.

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Pachychoroid disease spectrum: review article

Cited by 21 publications

References 118 publications

Significant Visual Impairment after Short-Lasting Central Serous Chorioretinopathy

Significant Visual Impairment after Short-Lasting Central Serous Chorioretinopathy

Advancements in ophthalmic imaging for better understanding of pachychoroid spectrum diseases: perspective

NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the Retina: A New Phenotype and its Differential Diagnosis

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