Pacemaker Potential and C-Fibre's Impulses Evoked by Stimuli of the Vagus Nerve

Goto, Kashima

doi:10.2974/kmj1951.29.165

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2003

2005

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Cited by 2 publications

(2 citation statements)

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“…Experimental proofs for such ideas arise from experiments with cutting and artificial stimulation of extracardiac (parasympathetic and sympathetic) nerves. It has also shown that these effects were caused by the acceleration of spontaneous depolarisation of the pacemaker cells by stimulation of the sympathetic nerves, and vice versa, slowing it down under parasympathetic influence 1−3 …”

mentioning

confidence: 99%

Alternative view on the mechanism of cardiac rhythmogenesis

Pokrovskii

2003

Heart, Lung and Circulation

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mentioning

confidence: 99%

Alternative view on the mechanism of cardiac rhythmogenesis

Pokrovskii

2003

Heart, Lung and Circulation

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“…Experiments in which these nerves were cut and subsequently electrically stimulated, provided the basis for these ideas. It has been established that the increase in heart rate produced by sympathetic nerve stimulation is due to accelerated depolarization of the pacemaker cells whereas parasympathetic vagal stimulation causes slowing of pacemaker depolarization [1,7,18]. However, the changes in heart rate so produced, cannot provide the whole spectrum of cardiac adaptive reactions in the whole organism.…”

Section: Introductionmentioning

confidence: 99%

Integration of the Heart Rhythmogenesis Levels: Heart Rhythm Generator in the Brain

Pokrovskii

2005

J. Integr. Neurosci.

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We propose that along with the intracardiac pacemaker, a generator of cardiac rhythm exists in the central nervous system--in the efferent structures of the cardiovascular center of the medullar oblongata. Signals in the medulla oblongata arise as a result of the hierarchic interaction of the brain structures. Neural signals originating there in the form of bursts of impulses conduct to the heart along the vagus nerves and after interaction with cardiac pacemaker structures, cause generation of the cardiac pulse in exact accordance with the frequency of "neural bursts". The intrinsic cardiac rhythm generator (the sinus node) is a life-sustaining factor that maintains the heart pumping function when the central nervous system is in a stage of deep inhibition, (e.g., under anesthesia or during unconsciousness). The brain generator is the factor that provides heart adaptive reactions in behaving organism. The integration of the two levels of rhythmogenesis in the brain and heart provides reliability and functional perfection of the cardiac rhythm generation system in the whole organism.

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Pacemaker Potential and C-Fibre's Impulses Evoked by Stimuli of the Vagus Nerve

Cited by 2 publications

References 15 publications

Alternative view on the mechanism of cardiac rhythmogenesis

Alternative view on the mechanism of cardiac rhythmogenesis

Integration of the Heart Rhythmogenesis Levels: Heart Rhythm Generator in the Brain

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