Paced mating behavior in the naturally cycling and the hormone-treated female rat

Zipse, Lauryn R; Brandling‐Bennett, Erica M.; Clark, Ann S.

doi:10.1016/s0031-9384(00)00242-0

Cited by 67 publications

(12 citation statements)

References 23 publications

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“…Since the females employed in the present experiment were fully primed, there was no reason to expect any effect on lordosis. It can also be mentioned that the physiological importance of the inhibitory effects in females treated with suboptimal doses of EB is questionable since intact, cycling females are fully receptive and show a pacing behavior similar to what was observed in the present experiment (Zipse et al 2000). Nevertheless, an effect of SB206,553 on some aspects of pacing could not be excluded even in fully receptive females.…”

Section: Discussionsupporting

confidence: 41%

Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Kaspersen

Ågmo

2011

Psychopharmacology

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Section: Discussionsupporting

confidence: 41%

Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Kaspersen

Ågmo

2011

Psychopharmacology

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“…However, further studies are needed in the paced mating paradigm (and without the prior testing activity) to determine if fluoxetine truly does reduce the female's propensity for mating. Such experiments will be important because the female's latency to return to the male has been interpreted to reflect the degree of the female's sexual motivation [14, 37, 38]. Thus, the fact that fluoxetine-treated females tended to leave and stay away from the male might evidence a fluoxetine-induced reduction in the female's motivation for mating.…”

Section: 0 Discussionmentioning

confidence: 99%

Factors influencing fluoxetine-induced sexual dysfunction in female rats

Adams

Heckard

Hassell

et al. 2012

Behavioural Brain Research

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Treatment with selective serotonin reuptake inhibitors, such as fluoxetine, produces sexual side effects with low sexual desire being the most prevalent effect in females. In few studies have preclinical models for such antidepressant-induced sexual dysfunction been fruitful. In the current manuscript, the effects of fluoxetine on multiple measures of female sexual motivation and sexual receptivity were examined. Ovariectomized, Fischer rats were primed with 10 μg estradiol benzoate and 500 μg progesterone. Partner preference, active investigation of the male, and measures of sexual behavior were examined after injection with 15 mg/kg fluoxetine. Factors (pretesting for sexual behavior, size of the test arena, non-contact time with a male) that differ among experiments designed to study antidepressant-induced female rat sexual dysfunction were studied. The male preference ratio was not affected by fluoxetine treatment but active investigation of the male was reduced; lordosis behavior was inhibited and pretesting for sexual receptivity amplified fluoxetine's inhibition; size of the testing arena or non-contact experience with the male had no effect. Regardless of test condition, when given the opportunity to escape from the male, fluoxetine-treated females displayed escape behavior. Measures of male preference and active investigation, but not lordosis behavior, appeared to be affected by fluoxetine's impact on activity. The collective data provided a behavioral profile of fluoxetine-induced sexual dysfunction. These findings reinforce the value of multiple measures when attempting to model antidepressant-induced female sexual dysfunction.

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“…Nevertheless, when given the opportunity in a suitable environment, an oestrous female will approach and withdraw from the male, hence controlling the number and timing of sexual contacts. This pattern is known as paced mating behaviour 6 . Sexual behaviour in female rats is primarily regulated by oestradiol and progesterone, but it may be influenced by different neurotransmitters and peptides 7 .…”

Section: Introductionmentioning

confidence: 99%

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

Zavatti

Carnevale

Benelli

et al. 2011

Clinical and Experimental Pharmacology and Physiology

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1. The aim of the present study was to investigate the effect of the cannabinoid antagonist/inverse agonist SR 141716 (SR) on the receptive behaviour and sexual motivation of female rats. 2. Partner preference, receptivity and proceptivity were evaluated in ovariectomized female rats primed with oestrogen and progesterone and administered SR (1 or 2.5 mg/kg, i.p.) 20 min prior to testing. 3. In the partner preference test, a reduced interest in both stimulus animals (a sexually active male and an ovariectomized hormone-primed female) was detected in rats treated with SR at both doses, but no effect on preference score was observed. In the receptivity test, pronounced reductions in lordosis quotient, lordosis rating and in the percentage of receptive females were found in SR-treated rats compared with control rats. Proceptive behaviours were not significantly affected by either dose of SR. 4. In addition, we explored the behavioural effects induced by SR in female rats using the open field test. Only at the higher dose (i.e. 2.5 mg/kg) did SR markedly increased grooming and scratching behaviour. 5. The results demonstrate the ability of SR to reduce female sexual receptivity, but not sexual motivation. The reduction does not seem strictly related to the motor alterations induced by the cannabinoid antagonist.

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Paced mating behavior in the naturally cycling and the hormone-treated female rat

Cited by 67 publications

References 23 publications

Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists

Factors influencing fluoxetine-induced sexual dysfunction in female rats

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

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