PacBio sequencing of human fecal samples uncovers the DNA methylation landscape of 22 673 gut phages
Yanqiang Ding,
Liuyang Zhao,
Guoping Wang
et al.
Abstract:Gut phages have an important impact on human health. Methylation plays key roles in DNA recognition, gene expression regulation and replication for phages. However, the DNA methylation landscape of gut phages is largely unknown. Here, with PacBio sequencing (2120×, 4785 Gb), we detected gut phage methylation landscape based on 22 673 gut phage genomes, and presented diverse methylation motifs and methylation differences in genomic elements. Moreover, the methylation rate of phages was associated with taxonomy … Show more
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