PACAP Modulates Distinct Neuronal Components to Induce Cell-Specific Plasticity at Central and Autonomic Synapses

Starr, Eric R.; Margiotta, Joseph F.

doi:10.1007/978-3-319-35135-3_7

Cited by 3 publications

(1 citation statement)

References 114 publications

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“…In other studies, PAC1 receptor levels correlated with increased startle response [ 92 , 93 ], a marker of PTSD [ 94 , 95 , 96 ]. PACAP plays an important role in physiological stress responses, including those mediated by the sympathetic and parasympathetic nervous system [ 97 ]. PACAP distribution in brain areas involved in stress and emotion, including the hypothalamus, bed nucleus of the stria terminalis, and amygdala, suggests PACAP’s involvement in limbic, autonomic, and neuroendocrine functions [ 98 , 99 ].…”

Section: Neurobiology Of Stress-related Psychiatric Disordersmentioning

confidence: 99%

Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders

Bremner

Gurel

Wittbrodt

et al. 2020

JPM

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Background: Vagal Nerve Stimulation (VNS) has been shown to be efficacious for the treatment of depression, but to date, VNS devices have required surgical implantation, which has limited widespread implementation. Methods: New noninvasive VNS (nVNS) devices have been developed which allow external stimulation of the vagus nerve, and their effects on physiology in patients with stress-related psychiatric disorders can be measured with brain imaging, blood biomarkers, and wearable sensing devices. Advantages in terms of cost and convenience may lead to more widespread implementation in psychiatry, as well as facilitate research of the physiology of the vagus nerve in humans. nVNS has effects on autonomic tone, cardiovascular function, inflammatory responses, and central brain areas involved in modulation of emotion, all of which make it particularly applicable to patients with stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD) and depression, since dysregulation of these circuits and systems underlies the symptomatology of these disorders. Results: This paper reviewed the physiology of the vagus nerve and its relevance to modulating the stress response in the context of application of nVNS to stress-related psychiatric disorders. Conclusions: nVNS has a favorable effect on stress physiology that is measurable using brain imaging, blood biomarkers of inflammation, and wearable sensing devices, and shows promise in the prevention and treatment of stress-related psychiatric disorders.

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Section: Neurobiology Of Stress-related Psychiatric Disordersmentioning

confidence: 99%

Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders

Bremner

Gurel

Wittbrodt

et al. 2020

JPM

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Investigating the impact of PACAP on thermal stability of G-actin by differential scanning calorimetry

Bukovics,

Tamás,

Tóth

et al. 2024

J Therm Anal Calorim

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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a bioactive peptide known for its diverse effects on the nervous system. While numerous studies have demonstrated the neuroprotective properties of PACAP, its role in tissue regeneration and potential as a therapeutic agent remain to be fully understood. Specifically, the understanding of PACAP’s impact on cytoskeletal dynamics, particularly the organization and disorganization of actin filament networks, is limited due to the scarcity of in vitro studies in this area. Additionally, the interaction between PACAP and actin has been minimally explored, and the influence of PACAP on the thermal stability of actin is completely unknown. To address these gaps, the current study aimed to investigate the impact of different forms and fragments of PACAP on the thermal denaturation and renaturation of Ca2+-G-actin using a differential scanning calorimetry (DSC) approach. Our primary objective was to determine whether PACAP modulates the thermal stability of Ca2+-G-actin and establish a temperature-dependent pattern of any structural alterations that may occur as a result of PACAP interaction. Two PACAP forms exist in vivo: the 38 amino-acid length PACAP38 and the PACAP27, the latter truncated at the C-terminal. In the PACAP38 + Ca2+-G-actin mixture, the DSC scans exhibited a mild decrease in actin denaturation temperature compared to the control, plus an exotherm appeared in the high-temperature range with a significantly increased calorimetric enthalpy. The truncated PACAP27 produced a slight increase in actin denaturation temperature with the same exotherm without significant alteration in enthalpy. In PACAP6-38 mixture (i.e., an artificial fragment of PACAP38 + Ca2+-G-actin), there was no change in the denaturation temperature of actin and no plus exotherm, but significant ΔHcal was observed. With the modified PACAP6-27 (another artificial fragment), the exotherm was absent, but the actin denaturation temperature and enthalpy increased compared to the control. Through this research, we sought to elucidate the underlying mechanisms of PACAP’s effects on actin dynamics and provide valuable insights into the potential therapeutic applications of PACAP in the context of cytoskeletal organization and neuronal regeneration. The findings of this study may contribute to the development of novel strategies targeting actin-related processes for neuroprotection and neural tissue repair.

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Pituitary adenylate cyclase activating polypeptide induces long-term, transcription-dependent plasticity and remodeling at autonomic synapses

Starr

Margiotta

2017

Molecular and Cellular Neuroscience

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PACAP Modulates Distinct Neuronal Components to Induce Cell-Specific Plasticity at Central and Autonomic Synapses

Cited by 3 publications

References 114 publications

Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders

Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders

Investigating the impact of PACAP on thermal stability of G-actin by differential scanning calorimetry

Pituitary adenylate cyclase activating polypeptide induces long-term, transcription-dependent plasticity and remodeling at autonomic synapses

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