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Kawasaki,

doi:10.1016/0925-5710(95)00350-2

Cited by 18 publications

(3 citation statements)

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“…Moreover, the prominent siRNA signal detected in tumor, the high signals in kidney are consistent with our previous publications that major clearance route of this nanoparticle is kidney [ 51 ]. We also detected some siRNA signal in the liver, lung, and brain, which may be due to lymphoma associated inflammation in central nervous system [ 57 , 58 , 59 , 60 , 61 ] and other organs. Because our previous studies have shown that this delivery system spares health brain [ 45 ], lung [ 50 ], and other organs/tissues, and is not cleared appreciably by a healthy liver [ 51 ], the present results support the observation that this nanomaterial permeates leaky vasculature associated with tumoral and inflammatory microenvironment.…”

Section: Resultsmentioning

confidence: 95%

Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma

et al. 2021

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Adult T-cell leukemia/lymphoma (ATLL) is an aggressive, clonal malignancy of mature T cells caused by human T-cell leukemia virus type 1. Although it is a rare tumor type, it serves as an excellent model of a virus driven process that transforms cells and engenders a highly malignant tumor that is extraordinarily difficult to treat. The viral transcriptional transactivator (Tax) in the HTLV-1 genome directly promotes tumorigenesis, and Tax-induced oncogenesis depends on its ability to constitutively activate NF-κB signaling. Accordingly, we developed and evaluated a nano-delivery system that simultaneously inhibits both canonical (p65) and noncanonical (p100) NF-κB signaling pathways locally in tumors after systemic administration. Our results demonstrate that siRNA is delivered rapidly to ATLL tumors after either i.p. or i.v. injection. The siRNA treatment significantly reduced both p65 and p100 mRNA and protein expression. Anti-NF-κB nanotherapy significantly inhibited tumor growth in two distinct tumor models in mice: a spontaneous Tax-driven tumor model, and a Tax tumor cell transplant model. Moreover, siRNA nanotherapy sensitized late-stage ATLL tumors to the conventional chemotherapeutic agent etoposide, indicating a pleiotropic benefit for localized siRNA nanotherapeutics.

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Section: Resultsmentioning

confidence: 95%

Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma

et al. 2021

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“…The matrix-valued memory kernel δK αβ µ (q, t) can be expressed in terms of an irreducible memory kernel which is more suitable for applying MCT approximations [85,86]. The concept of irreducible memory functions is also present in modified MCT approaches, e.g.…”

Section: Irreducible Memory Kernelmentioning

confidence: 99%

Dynamic properties of quasi-confined colloidal hard-sphere liquids near the glass transition

Schrack,

Petersen,

Jung

et al. 2020

Preprint

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The complex behavior of confined fluids arising due to a competition between layering and local packing can be disentangled by considering quasi-confined liquids, where periodic boundary conditions along the confining direction restore translational invariance. This system provides a means to investigate the interplay of the relevant length scales of the confinement and the local order. We provide a modecoupling theory of the glass transition (MCT) for quasi-confined liquids and elaborate an efficient method for the numerical implementation. The nonergodicity parameters in MCT are compared to computer-simulation results for a hard-sphere fluid. We evaluate the nonequilibrium state diagram and investigate the collective intermediate scattering function. For both methods, non-monotonic behavior depending on the confinement length is observed.

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“…Acute, lymphomatous, chronic, and smoldering variants of ATLL have been identified. CNS involvement is more common in the lymphomatous and acute forms [ 2 , 3 ]. Herein, we report a rare case of ATLL that was originally diagnosed as isolated CNS T-cell lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Adult T-Cell Lymphoma/Leukemia Presenting as Isolated Central Nervous System T-Cell Lymphoma

et al. 2014

Case Reports in Hematology

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Adult T-cell leukemia/lymphoma (ATLL) is a T-cell neoplasm, associated with infection by the retrovirus human T-lymphotropic virus type 1 (HTLV-1). Central nervous system (CNS) involved by ATLL is often occurred in advanced disease, such as acute and lymphomatous variants. On the other hand, isolated CNS lymphoma is rare. We repot a 50-year-old woman who presented with multiple infiltrative brain lesions on the magnetic resonance (MR) imaging. Results of initial biopsy of brain tumor indicated CNS vasculitis. The patient received one course of high-dose methotrexate and MR imaging of brain revealed remission of infiltrative lesions. Two years later, new brain lesions were detected. Histopathologic examination of specimens via craniotomy revealed T-cell lymphoma. The patient responded poorly to subsequent chemotherapy, and salvage whole-brain irradiation was performed. Six months later, the patient had hepatosplenomegaly, hypercalcemia, and multiple lymphocytes with a cloverleaf appearance in circulation. Results of flow cytometry analysis of peripheral blood indicated ATLL and antibodies to human T-lymphotropic virus type 1 (HTLV-1) were detected. Clinicians should screen HTLV-1 infection when patients are diagnosed with peripheral T-cell lymphoma. Combined antiviral therapy and intensive chemotherapy may improve the outcomes of ATLL.

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Cited by 18 publications

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Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma

Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma

Dynamic properties of quasi-confined colloidal hard-sphere liquids near the glass transition

Adult T-Cell Lymphoma/Leukemia Presenting as Isolated Central Nervous System T-Cell Lymphoma

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