Abstract:The aim of this study was to develop a pH responsive enteric coated extended release pellets containing a model drug flurbiprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets were prepared by using extrusion/ spheronization method. Core pellets were coated with polymer Eudragit RS30D in a coating pan to achieve a sustainable release for 12 hours. A ph responsive barrier coat of Eudragit L 100-55 was employed in a coating pan for abstaining release in acidic medi… Show more
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