P98. Differential expression of genes in the corpus, fundus and antrum regions of the stomach in grower pigs

Kiernan, Dillon P.; O’Doherty, John V.; Maher, Sam; Ryan, M. F.; Sweeney, T.

doi:10.1016/j.anscip.2022.03.301

Cited by 2 publications

(2 citation statements)

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“…The low gastric pH and the acidification of feed consumed play an important role in the defense mechanisms against pathogenic microbes [ 23 ]. The corpus region of the stomach has a significantly higher expression of genes involved in acid and enzyme production, while the antrum has significantly higher gastrin expression [ 24 ].…”

Section: Mouth and Stomachmentioning

confidence: 99%

Gut Health and Influencing Factors in Pigs

Szabó

Lugata

Ortega

2023

Animals

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The gastrointestinal tract (GIT) is a complex, dynamic, and critical part of the body, which plays an important role in the digestion and absorption of ingested nutrients and excreting waste products of digestion. In addition, GIT also plays a vital role in preventing the entry of harmful substances and potential pathogens into the bloodstream. The gastrointestinal tract hosts a significant number of microbes, which throughout their metabolites, directly interact with the hosts. In modern intensive animal farming, many factors can disrupt GIT functions. As dietary nutrients and biologically active substances play important roles in maintaining homeostasis and eubiosis in the GIT, this review aims to summarize the current status of our knowledge on the most important areas.

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Section: Mouth and Stomachmentioning

confidence: 99%

Gut Health and Influencing Factors in Pigs

Szabó

Lugata

Ortega

2023

Animals

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“…For example, live Lactobacilli as probiotics can enhance the expression of IL-6 in intestinal epithelial cells to promote B cell differentiation, exerting immune-regulating effects without inducing inflammatory responses (9). Certain probiotics (such as Lactobacilli and Bacillus) can stimulate the elongation of intestinal villi, which increases the contact area and improves absorption efficiency, thereby enhancing the utilization and absorption functions of the intestine (10).…”

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confidence: 99%

Alleviating effect of Lactobacillus pentosus CQZC01 probiotic strain on antibiotic-induced diarrhea in mice

LIU,

CHENG,

LIU

et al. 2024

Acta Poloniae Pharmaceutica - Drug Research

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This experiment used mice as the experimental subjects to study the alleviating effect of Lactobacillus pentosus CQZC01 (LPCQZC01) on antibiotic-induced diarrhea in mice. After adaptive feeding for seven days, Kunming (KM) mice were randomly divided into the following groups: positive control group, model group, normal group, high concentration group of LPCQZC01 (H-LPCQZC01, 1×109 CFU/mL), and low concentration group of LPCQZC01 (L-LPCQZC01, 1×108 CFU/mL). Except for the normal group, mice were orally administered with lincomycin hydrochloride (120 mg/day) for 7 consecutive days. Changes in body weight, food intake, water consumption, and fecal water content of mice were observed. A histological examination of mouse colon and small intestine sections was done to find out if Lactobacillus pentosus CQZC01 may help mice with antibiotic-induced diarrhea. The findings demonstrated that, in comparison to the model group, mice in the H-LPCQZC01 and L-LPCQZC01 groups had considerably lower blood levels of nterleukin-6 (IL-6), interleukin-17A (IL-17A), 5-hydroxytryptamine (5-HT), and malondialdehyde (MDA), and other variables. In comparison to the model group, the fecal water content in the H-LPCQZC01 and L-LPCQZC01 groups was considerably lower. The H-LPCQZC01 and L-LPCQZC01 groups consumed more food and liquids than the model group did. The H-LPCQZC01 and L-LPCQZC01 groups had more intact colon walls and more compact, regular, and organized intestinal villi. H-LPCQZC01 and L-LPCQZC01 groups had the lower CFTR, EGFR expression and stronger NHE1, NHE2 expression than model group. This study reveals that Lactobacillus pentosus CQZC01 may treat inflammatory lesions in the mouse intestines and successfully treat antibiotic-induced diarrhea in mice.

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P98. Differential expression of genes in the corpus, fundus and antrum regions of the stomach in grower pigs

Cited by 2 publications

References 0 publications

Gut Health and Influencing Factors in Pigs

Gut Health and Influencing Factors in Pigs

Alleviating effect of Lactobacillus pentosus CQZC01 probiotic strain on antibiotic-induced diarrhea in mice

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