P95 Blood Pressure Variability, Arterial Stiffness and Arterial Remodeling – The Maastricht Study

Zhou, Tan Lai; Henry, Ronald M.A.; Stehouwer, Coen D.A.; Sloten, Thomas T. van; Reesink, Koen D.

doi:10.1016/j.artres.2018.10.148

Cited by 5 publications

(6 citation statements)

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“…Arterial stiffening may alter pulse wave dynamics, potentially causing a buildup or otherwise erratic flow of blood and tissue perfusion 5,36,39 . Disrupted blood flow may be particularly detrimental to organs with high metabolic demand like the brain 35,36,38,[40][41][42][43][44] . The brain's smaller cerebral arterioles and capillaries may be the most vulnerable, where the majority of nutrient transfer, nutrient influx, and waste clearance takes place across the blood-brain barrier, which could be related to the present study findings.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Sible

Yew

Jang

et al. 2022

Sci Rep

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Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1–42: Aβ1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1–42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer’s disease pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Sible

Yew

Jang

et al. 2022

Sci Rep

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“…We have shown that BPV, an important predictor of cardiovascular risk, is positively associated with mean BP but were unable to demonstrate any significant associations with age, sex or concurrent arterial stiffness when the mean BP was accounted for. Arterial stiffening may be a long-term consequence rather than a cause of BPV [15], hence the lack of association seen in cross-sectional regression. Increased BMI was associated with a higher baseline BP and increased variability of night-time measurements, but not daytime pressures, which may reflect findings by others that higher BMI is associated with increased BPV, and disruption of normal nocturnal dipping patterns [29,30].…”

Section: Discussionmentioning

confidence: 99%

“…Some degree of BPV is a normative property, but a high variability has been shown to be associated with an increased risk of cardiovascular outcomes, independent of the mean systolic pressure [11][12][13]. Determinants of increased BPV may include general cardiovascular risk factors such as increasing age, arterial stiffness and adverse lipid profiles [14,15] amongst others. Elucidation of factors associated with BPV in this cohort may provide clues to modifiable risk factors for high BPV in cohorts at a higher risk of cardiovascular morbidities.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of sequential ambulatory blood pressure and pulse wave velocity measurements in normotensive and hypertensive individuals

Keehn

Hall

Berry

et al. 2022

Journal of Hypertension

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Objective: Errors in blood pressure (BP) measurement account for a large proportion of misclassified hypertension diagnoses. Ambulatory blood pressure monitoring (ABPM) is often considered to be the gold standard for measurement of BP, but uncertainty remains regarding the degree of measurement error. The aim of this study was to determine reproducibility of sequential ABPM in a population of normotensive and well controlled hypertensive individuals.Methods: Individual participant data from three randomized controlled trials, which had recorded ABPM and carotid-femoral pulse wave velocity (PWV) at least twice were combined (n ¼ 501). We calculated within-individual variability of daytime and night-time BP and compared the variability between normotensive (n ¼ 324) and hypertensive (n ¼ 177) individuals. As a secondary analysis, variability of PWV measurements was also calculated, and multivariable linear regression was used to assess characteristics associated with blood pressure variability (BPV).Results: Within-individual coefficient of variation (CoV) for systolic BP was 5.4% (day) and 7.0% (night). Equivalent values for diastolic BP were 6.1% and 8.4%, respectively. No statistically significant difference in CoV was demonstrated between measurements for normotensive and hypertensive individuals. Within-individual CoV for PWV exceeded that of BP measurements (10.7%). BPV was associated with mean pressures, and BMI for night-time measurements. PWV was not independently associated with BPV. Conclusion:The variability of single ABPM measurements will still yield considerable uncertainty regarding true average pressures, potentially resulting in misclassification of hypertensive status and incorrect treatment regimes. Repeated ABPM may be necessary to refine antihypertensive therapy.

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“…This may suggest that BPV measures share similar underlying mechanisms that lead to MVD (even though individual measures of BPV are determined by different haemodynamic mechanisms) [62]. Fourth, the association between greater BPV and UAE may be the result of residual confounding because of low-grade inflammation [63,64], arterial stiffening [4,65], activation of the renin-angiotensin system [66,67], unhealthy dietary habits [68,69], physical inactivity [70,71] and lower socioeconomic status [72,73]. However, when we adjusted for low-grade inflammation, carotid-femoral pulse wave velocity, the diet score, moderate-to-vigorous physical activity and factors related to socioeconomic status (i.e.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure variability and microvascular dysfunction: the Maastricht Study

Zhou

Rensma

Baan

et al. 2020

Journal of Hypertension

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P95 Blood Pressure Variability, Arterial Stiffness and Arterial Remodeling – The Maastricht Study

Cited by 5 publications

References 0 publications

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Reproducibility of sequential ambulatory blood pressure and pulse wave velocity measurements in normotensive and hypertensive individuals

Blood pressure variability and microvascular dysfunction: the Maastricht Study

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