P8 First experiences with PGD after trophectoderm biopsy at Kinderwunsch Centrum Munich (KCM), Germany

Suttner, R.; Shakeshaft, D.; Koehler, Ulrich; Schön, Ulrike; Harasim, Th.; Wagner, A.; Holinski‐Feder, Elke; Rost, Imma; Würfel, W.

doi:10.1016/s1472-6483(12)60225-9

Reproductive BioMedicine Online

2012

DOI: 10.1016/s1472-6483(12)60225-9

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P8 First experiences with PGD after trophectoderm biopsy at Kinderwunsch Centrum Munich (KCM), Germany

R. Suttner¹,

D. Shakeshaft²,

Ulrich Koehler³

et al.

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“…First reports applying PGS on blastocysts were pub-lished from 2002 on [4,14]. Our PGS programme with trophectoderm biopsy (TEB) was introduced in 2010 [15], after the decision of the German Federal Supreme Court and according to the ESHRE guidelines [11,12]. The majority of PGD is done on day 3 embryos, however, the percentage of cycles with TEB is increasing [7,10].…”

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Pregnancy and Birth After a Two-Step PGD: Polar Body Diagnosis for Hemophilia A and Array CGH on Trophectoderm Cells for Chromosomal Aberrations

Würfel¹,

Suttner²,

Shakeshaft³

et al. 2013

Geburtsh Frauenheilk

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Objective: To demonstrate that a PGD program can be successfully established after the 2011 verdict of the German Bundestag concerning PGD. Material and Method: Eight years previously, the couple had had a daughter who suffered from clinically manifest hemophilia A due to an unbalanced X-inactivation, as well as microdeletion syndrome resulting in severe physical and mental disability. The couple wished to have a second child but refused the idea of a "trial" pregnancy. Given the indications for both, it was necessary to carry out polar body diagnosis (PBD) to rule out hemophilia A and, during the same cycle, a subsequent PGD on the blastocysts to rule out genetic aberrations. The PBD and PGD (trophectoderm biopsy, TEB) were performed after highdosage ovarian stimulation and ICSI fertilization of the oocytes. A blastocyst was successfully transferred on day 6. Results: The patient conceived immediately. The pregnancy developed normally and the patient gave birth to a girl in the 40th week of pregnancy. Post-natal examinations showed that the baby is free from hemophilia A and is developing normally both physically and mentally. Conclusion: Establishment of a PGD program is now possible after legalization of PGD in Germany. It is possible to apply two investigative techniques in a single treatment cycle if multifactorial diagnosis is required.

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Pregnancy and Birth After a Two-Step PGD: Polar Body Diagnosis for Hemophilia A and Array CGH on Trophectoderm Cells for Chromosomal Aberrations

Würfel¹,

Suttner²,

Shakeshaft³

et al. 2013

Geburtsh Frauenheilk

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P8 First experiences with PGD after trophectoderm biopsy at Kinderwunsch Centrum Munich (KCM), Germany

Cited by 1 publication

References 0 publications

Pregnancy and Birth After a Two-Step PGD: Polar Body Diagnosis for Hemophilia A and Array CGH on Trophectoderm Cells for Chromosomal Aberrations

Pregnancy and Birth After a Two-Step PGD: Polar Body Diagnosis for Hemophilia A and Array CGH on Trophectoderm Cells for Chromosomal Aberrations

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