P771 Hepcidin Involves in Hepatic Iron Overload and Liver Injury in Chronic Hepatitis C Virus Infection

Wang, R.; Zhao, Shilin; Du, Ji Mei; He, Haolan; Tan, P; Nan, Yuemin

doi:10.1016/s0168-8278(14)60932-6

Cited by 2 publications

(1 citation statement)

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“…To determine the value of transient elastography (FibroTouch), the cutoff LSM and FAP levels for the fibrosis and steatosis as well as the basal LSM and FAP levels of livers from healthy individuals must be known [18,20]. Several factors, such as age and obesity, can affect LSM and FAP reference levels in adults [14,21]. However, there is no study reporting the basal LSM and FAP levels of livers from healthy children in China with the transient elastography (FibroTouch).…”

Section: Introductionmentioning

confidence: 99%

The defining of the reference range of liver stiffness and fat attenuation parameter for healthy Chinese children

Zeng

Wang

2020

European Journal of Gastroenterology &Amp; Hepatology

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Aims We aimed to establish the basal reference levels of liver stiffness and accumulated fat in healthy Chinese children. Methods To obtain the liver stiffness measurement (LSM) and the fat attenuation parameter (FAP) levels, the transient elastography (FibroTouch) was used in pediatric patients aged 0 to 18 years. The patients were divided into groups as follows: newborns/infants (0–2 years), preschool children (3–5 years), elementary school children (6–11 years), and adolescents/teenagers (12–18 years). The weight, height and fasting liver function tests were performed. FibroTouch and abdominal ultrasonography were performed. Results The livers of 521 out of 1362 children (329 male; median age, 4.6 years; age range 0.2–17.6 years) were examined with the FibroTouch. The LSM reference range was 1.5–5.9 kPa, and the FAP reference range was 159.6–217.1 dB/m in healthy children from 0 to 18 years of age. The median LSM value was higher in males than that in females (3.5 vs. 3.2 kPa, respectively; P = 0.01). Conclusion For healthy children from 0 to 18 years in southern China, the LSM reference range was 1.5–5.9 kPa, and the FAP reference range was 159.6–217.1 dB/m. The LSM values were age-dependent in children from 3 to 18 years old, and the FAP values were age-independent in children from 0 to18 years old.

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Section: Introductionmentioning

confidence: 99%