p75NTR Ectodomain Ameliorates Cognitive Deficits and Pathologies in a Rapid Eye Movement Sleep Deprivation Mice Model

Zhu, Yang; Gao, Min; Hao, Huang; Gao, Shi-Hao; Liao, Ling-Yi; Tao, Yong; Cheng, Huan; Gao, Chang-Yue

doi:10.1016/j.neuroscience.2022.06.009

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…When mice with SD were administered a high dose of p75Ecd-Fc (10 mg/kg) peripherally, the Aβ and p75ECD levels in the hippocampus normalized. This intervention successfully addressed the cognitive deficits observed in SD mice [ 77 ]. Potential interaction between SD and disruption of circadian rhythm can impede the clearance of Aβ and tau proteins through the glial-vascular-lymphatic system.…”

Section: Mechanism Of Aβ Deposition and Tau Protein Hyperphosphorylat...mentioning

confidence: 99%

Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease

Han,

Yang,

Huang

2024

Heliyon

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Section: Mechanism Of Aβ Deposition and Tau Protein Hyperphosphorylat...mentioning

confidence: 99%

Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease

Han,

Yang,

Huang

2024

Heliyon

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“…Spontaneous alternation and novel arm exploration in a Y-maze (SD Instruments, San Diego, CA) were used to evaluate the learning and memory function. The experimental procedures were conducted as reported in the literature [31].…”

Section: Y Maze Testmentioning

confidence: 99%

An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia

Gao,

Xie,

Xie

et al. 2024

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Sevoflurane is an inhalation anaesthetic agent widely used in clinical settings. Despite good surgical outcomes using sevoflurane, patients frequently develop postoperative cognitive dysfunction (POCD). An enriched environment (EE), as a rehabilitation technique, could provide objects and tools to facilitate neuromotor and visual stimuli and brain activity, and is reported to improve cognitive functions. We aim to investigate the impairments of sevoflurane inhalation on cognitive function in mice and determine the benefits of EE in ameliorating POCD. Eighteen-month-old mice were exposed to sevoflurane inhalation for 2 h and then placed in standard environment (SE) or EE cages. The mice without sevoflurane exposure in standard or EE cages were used as controls. The behavioural tests include Morris water maze, Y maze and novel object recognition. Magnetic resonance imaging (MRI) was used to determine the blood circulation in the brains. The proangiogenic factors (CD31, angiopoietin-1, vascular endothelial growth factor, and N-cadherin) and neurotrophic (brain-derived neurotrophic factor, post-synaptic density protein 95) expression in hippocampus of aged mice were evaluated by Western blotting and RT-PCR analysis. Sevoflurane-exposed mice demonstrated reduced performance in learning, memory and spatial memory tests. Enriched environment improved the behavioural performance of sevoflurane-exposed animals. Sevoflurane exposure reduced the blood flow in the brains, and these effects were ameliorated by EE habitation. The EE also promoted the expression of angiogenic and neurotropic factors in sevoflurane-exposed animals. In summary, EE is effective in ameliorating the side-effects of sevoflurane exposure in aged mice.

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“…The available evidence suggests that REM sleep deprivation causes learning and memory impairment due to neuroinflammation [25,26], and the toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway is involved in sleep-deprivation-induced neuroinflammation [11]. A variety of active ingredients in traditional Chinese medicine, such as Suan-Zao-Ren decoction [27] and curcumin [28], can reduce hippocampal inflammation by inhibiting the TLR4/NF-κB signaling pathway and then improving learning and memory impairment in sleep-deprived rats.…”

Section: Introductionmentioning

confidence: 99%

Gastrodin Improves Cognitive Dysfunction in REM Sleep-Deprived Rats by Regulating TLR4/NF-κB and Wnt/β-Catenin Signaling Pathways

Liu

et al. 2023

Brain Sciences

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Gastrodin is the active ingredient in Gastrodia elata. Our previous studies demonstrated that gastrodin ameliorated cerebral ischemia–reperfusion and hypoperfusion injury and improved cognitive deficit in Alzheimer’s disease. This study aims to examine the effects of gastrodin on REM sleep deprivation in rats. Gastrodin (100 and 150 mg/kg) was orally administered for 7 consecutive days before REM sleep deprivation. Seventy-two hours later, pentobarbital-induced sleep tests and a Morris water maze were performed to measure REM sleep quality and learning and memory ability. Histopathology was observed with hematoxylin–eosin staining, and the expression of the NF-κB and Wnt/β-catenin signaling pathways was examined using Western blot. After REM sleep deprivation, sleep latency increased and sleep duration decreased, and the ability of learning and memory was impaired. Neurons in the hippocampal CA1 region and the cortex were damaged. Gastrodin treatment significantly improved REM sleep-deprivation-induced sleep disturbance, cognitive deficits and neuron damage in the hippocampus CA1 region and cerebral cortex. A mechanism analysis revealed that the NF-κB pathway was activated and the Wnt/β-catenin pathway was inhibited after REM sleep deprivation, and gastrodin ameliorated these aberrant changes. Gastrodin improves REM sleep-deprivation-induced sleep disturbance and cognitive dysfunction by regulating the TLR4/NF-κB and Wnt/β-catenin signaling pathways and can be considered a potential candidate for the treatment of REM sleep deprivation.

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p75NTR Ectodomain Ameliorates Cognitive Deficits and Pathologies in a Rapid Eye Movement Sleep Deprivation Mice Model

Cited by 7 publications

References 40 publications

Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease

Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease

An enriched environment promotes cognitive recovery and cerebral blood flow in aged mice under sevoflurane anaesthesia

Gastrodin Improves Cognitive Dysfunction in REM Sleep-Deprived Rats by Regulating TLR4/NF-κB and Wnt/β-Catenin Signaling Pathways

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