P751: Characterizing Circular Rna Expression in Myelodysplastic Syndrome

Wedge, Eileen; Côme, Christophe; Hansen, Jakob Werner; Jespersen, Jakob S.; Dahl, Mette; Schöllkopf, Claudia; Raaschou‐Jensen, Klas; Porse, Bo T.; Kristensen, Lasse Sommer; Grønbæk, Kirsten

doi:10.1097/01.hs9.0000845888.83823.cf

Cited by 2 publications

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“…Additionally, global circRNA expression has been found to be upregulated in the continuum from normal hematopoiesis to clonal cytopenias of undetermined significance (CCUS) and further to MDS. Even among MDS patients, a higher risk group was correlated with increased global circRNA expression and a "Myeloid Circ Score" was developed based on 14 specific circRNAs with potential prognostic value to stratify patients in terms of risk and disease outcomes [97]. Another research group found 145 circRNAs to be upregulated and 224 downregulated in MDS patients compared to healthy controls.…”

Section: Circular Rnasmentioning

confidence: 99%

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Cancers

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Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

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Section: Circular Rnasmentioning

confidence: 99%

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Cancers

View full text Add to dashboard Cite

show abstract

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

Georgoulis,

Koumpis,

Hatzimichael

2023

Preprint

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Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia and an increased risk for evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review will present a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.

show abstract

P751: Characterizing Circular Rna Expression in Myelodysplastic Syndrome

Cited by 2 publications

References 0 publications

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

The Role of Non-Coding RNAs in Myelodysplastic Neoplasms

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