P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke

Deshpande, Sachin S.; Malik, Subash C.; Conforti, Pasquale; Lin, Jia-di; Chu, Yu-Hsuan; Nath, Suvra; Greulich, Franziska; Dumbach, Meike-Ast; Uhlenhaut, N. Henriette

doi:10.1007/s00441-021-03539-z

Cited by 11 publications

(8 citation statements)

References 57 publications

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“…In the brain, new neurons are produced in the SVZ around the ventricle and the SGZ in the hippocampus, where neurogenesis occurs most actively and continuously [ 25 , 26 ]. Many studies have shown that when the brain is abnormal, the dividing neuroblasts move to the lesion location, and the migrated cells surround the lesion and slow its progression [ 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation

Seo

Han

Song

et al. 2023

IJMS

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Endogenous neural stem cells (eNSCs) in the adult brain, which have the potential to self-renew and differentiate into functional, tissue-appropriate cell types, have raised new expectations for neurological disease therapy. Low-intensity focused ultrasound (LIFUS)-induced blood–brain barrier modulation has been reported to promote neurogenesis. Although these studies have reported improved behavioral performance and enhanced expression of brain biomarkers after LIFUS, indicating increased neurogenesis, the precise mechanism remains unclear. In this study, we evaluated eNSC activation as a mechanism for neurogenesis after LIFUS-induced blood–brain barrier modulation. We evaluated the specific eNSC markers, Sox-2 and nestin, to confirm the activation of eNSCs. We also performed 3′-deoxy-3′[18F] fluoro-L-thymidine positron emission tomography ([18F] FLT-PET) to evaluate the activation of eNSCs. The expression of Sox-2 and nestin was significantly upregulated 1 week after LIFUS. After 1 week, the upregulated expression decreased sequentially; after 4 weeks, the upregulated expression returned to that of the control group. [18F] FLT-PET images also showed higher stem cell activity after 1 week. The results of this study indicated that LIFUS could activate eNSCs and induce adult neurogenesis. These results show that LIFUS may be useful as an effective treatment for patients with neurological damage or neurological disorders in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation

Seo

Han

Song

et al. 2023

IJMS

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show abstract

“…This reparative mechanism involves restoring damaged tissue and containing future expansion of the lesion. 51 Nevertheless, the quantity of activated endogenous NSCs within the organism is constrained. Furthermore, many of these endogenous NSCs tend to develop into glial cells due to adverse microenvironmental conditions.…”

Section: How Effective Is Neural Stem Cell Therapy For Ischemic Strokementioning

confidence: 99%

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Zhu,

Zhang,

Feng

et al. 2024

IJN

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Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are a type of stem cell that are only found inside the nervous system. These cells can differentiate into various kinds of cells, potentially regenerating or restoring neural networks within areas of the brain that have been destroyed. This review begins by providing an introduction to the existing therapeutic approaches for ischemic stroke, followed by an examination of the promise and limits associated with the utilization of NSCs for the treatment of ischemic stroke. Subsequently, a comprehensive overview was conducted to synthesize the existing literature on the underlying processes of neural stem cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy in the context of ischemic stroke. These mechanisms encompass neuroprotection, inflammatory response suppression, and endogenous nerve and vascular regeneration facilitation. Nevertheless, the clinical translation of NSC-sEVs is hindered by challenges such as inadequate targeting efficacy and insufficient content loading. In light of these limitations, we have compiled an overview of the advancements in utilizing modified NSC-sEVs for treating ischemic stroke based on current methods of extracellular vesicle modification. In conclusion, examining NSC-sEVs-based therapeutic approaches is anticipated to be prominent in both fundamental and applied investigations about ischemic stroke.

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“…Neurogenesis has a pivotal role in the recovery process of the brain after stroke. Recently, Deshpande et al (2022) demonstrated the critical contribution of p75NTR to the migration of neural stem cells, which were produced in the SVZ after stroke [ 51 ]. It was revealed that p75NTR KO mice exhibited reduced SVZ neural stem cell migration towards the lesion area after cortical brain injury [ 51 ].…”

Section: Roles Of Bdnf/trkb System In Cns Neuronsmentioning

confidence: 99%

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

Numakawa

Kajihara

2023

Life

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The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. Developing evidence demonstrates that decreased cell survival, synaptic dysfunction, and reduced neurogenesis are involved in the pathogenesis of AD. On the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB, have multiple roles in the central nervous system (CNS), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. Thus, many investigations regarding therapeutic approaches to AD, and/or the screening of novel drug candidates for its treatment, focus on upregulation of the BDNF/TrkB system. Furthermore, current studies also demonstrate that GDNF, IGF1, and bFGF, which play roles in neuroprotection, are associated with AD. In this review, we introduce data demonstrating close relationships between the pathogenesis of AD, neurotrophic factors, and drug candidates, including natural compounds that upregulate the BDNF-mediated neurotrophic system.

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P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke

Cited by 11 publications

References 57 publications

Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation

Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation

Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

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