P72 Catastrophic antiphospholipid syndrome, genetic and acquired thrombophilia

Features of the Course of Pregnancy and Childbirth in Woman with a History of Non-Developing Pregnancy in the Samarkand Region

“…In the structure of early reproductive losses, one of the main places is occupied by nondeveloping pregnancy (NP), the frequency of which remains stably high [1][2][3][4]. At the same time, despite numerous studies on this issue, the proportion of unexplained causes of NP still remains high and, according to different authors, ranges from 25 to 57% [5][6][7][8].…”

“…Most researchers believe that a persistent viral bacterial infection occupies the leading place in the etiology of NP, and chronic endometritis forms the basis of the pathogenesis of this pathology [6,7,[10][11][12]. So, according to VE Radzinsky [7], genital infection was detected in 96% of women with NP.…”

“…Most researchers believe that a persistent viral bacterial infection occupies the leading place in the etiology of NP, and chronic endometritis forms the basis of the pathogenesis of this pathology [6,7,[10][11][12]. So, according to VE Radzinsky [7], genital infection was detected in 96% of women with NP. Changes in chronic endometritis interfere with normal implantation and placentation and form a pathological response to pregnancy, which leads to early reproductive losses.…”

Age-Related Features of Detectability of Xenobiotic Enzyme Gene Polymorphism in Pregnant Women with Fetal Growth Restriction Syndrome

“…indicators of the level of specificity and sensitivity of the del / + polymorphism of the GSTT1 gene were SE = 0.8 and SP = 0.75, respectively, at significantly high values (OR = 11.7; 95% CI 5.132-26.9). At the same time, the calculated AUC indicator demonstrates a high level of effectiveness for predicting the development of the disease, which indicates the possible independent effect of this polymorphism on the risk of pathology development[22][23][24][25][26][27][28]. The SE and SP indices of the combined variant of the del polymorphisms of the GSTM1 + GSTT1 genes deviate towards sensitivity and are equal to 0.86 and 0.43, respectively and the efficiency rating is 0.65.…”