P688 Demographic, clinical, and therapeutic characteristics of a cohort of 238 patients with ulcerative colitis from two medical centres from Uruguay

Luciano, Mg; Noria, Alejandro; Iade, Beatriz

doi:10.1093/ecco-jcc/jjx180.815

Cited by 5 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 18 , 19 A low proportion of patients with UC were current smokers, ranging from 0.0% in Mexico City to 16.4% in Montevideo, Uruguay. 29 , 36 The majority of patients were non-smokers (ranging from 60.1% in Montevideo, Uruguay to 91.3% in Mexico City), with the exception of Sergipe, Brazil, in which the majority of patients (76.1%) were ex-smokers. 18 , 29 , 36 …”

Section: Resultsmentioning

confidence: 99%

“… 16 , 24 Colectomy rates varied between countries, with 22% of patients in Puerto Rico, 10.5% in Montevideo, Uruguay, 10.1% in Mexico City and 1.5–3.4% in Bahia, Brazil requiring a colectomy. 16 , 17 , 29 , 34 , 36 In Montevideo, Uruguay, 5.0% of patients underwent proctocolectomy (3.8% pouch and 1.3% definitive ileostomy) and 4.2% of patients required a colectomy. 36 …”

Section: Resultsmentioning

confidence: 99%

“…18,19 A low proportion of patients with UC were current smokers, ranging from 0.0% in Mexico City to 16.4% in Montevideo, Uruguay. 29,36 The majority of patients were nonsmokers (ranging from 60.1% in Montevideo, Uruguay to 91.3% in Mexico City), with the exception of Sergipe, Brazil, in which the majority of patients (76.1%) were ex-smokers. 18,29,36 Extraintestinal manifestations A total of 14 studies reported the presence of extraintestinal manifestations (EIMs) in patients with UC (Table 4), with the proportion of patients with UC who experienced EIMs ranging from approximately 26% in Mexico and Puerto Rico to 89.4% in Sergipe, Brazil.…”

Section: Patient Demographicsmentioning

confidence: 98%

“…19 In a study in Montevideo, Uruguay, 1.7% of patients developed colorectal cancer, and 7.6% of patients died. 36…”

Section: Treatmentmentioning

confidence: 99%

See 3 more Smart Citations

Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

View full text Add to dashboard Cite

The incidence and prevalence of ulcerative colitis (UC) has been reported to be rising in newly industrialised regions, such as Latin America. Here, we review data from published studies reporting demographics and clinical aspects of UC in Latin America to further understand epidemiology and disease burden. The incidence and prevalence of UC in Latin America varied between regions and studies, ranging between 0.04 to 8.00/100,000 and 0.23 to 76.1/100,000, respectively, and generally increased over the period from 1986 to 2015. The majority of patients with UC were female (53.6–72.6%) and urban residents (77.8–97.4%). Extraintestinal manifestations were reported in approximately 26–89.4% of patients. Use of biologic therapies was generally low (0.8–16.2%), with the exception of Mato Grosso do Sul, Brazil, with a greater proportion of patients tending to receive 5-aminosalicylates, immunosuppressants or corticosteroids; colectomy rates varied between studies (1.5–22%). A high proportion of patients had moderate to severe UC (45.9–73.0%) and, in 11 of 19 studies, the greatest proportion of patients had extensive disease (pancolitis). Colorectal cancer (0–1.7%) and mortality rates (0–7.6%) were low. This evaluation of published studies may influence therapeutic approaches and the development of strategies to improve healthcare access and patient outcomes, although further high-quality studies are required in patients with UC in Latin America.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Patient Demographicsmentioning

confidence: 98%

“…19 In a study in Montevideo, Uruguay, 1.7% of patients developed colorectal cancer, and 7.6% of patients died. 36…”

Section: Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

View full text Add to dashboard Cite

show abstract

“…[24] The larger case-series in LAC Countries are from 1946 to date are from Argentina [14,51,52], Barbados [13], Brazil [14,[53][54][55][56][57][58][59][60][61][62][63][64][65], Chile [66][67][68], Cuba [69], Peru [70,71], Puerto Rico [72][73][74][75] and Uruguay. [76][77][78] Most CD localizations were ileal-colonic and CD behavior was mostly inflammatory, followed by penetrant or stenotic. Perianal disease was identified roughly in one out of four cases.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

et al. 2020

View full text Add to dashboard Cite

Background and aims Ulcerative Colitis (UC) and Crohn's Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia.

show abstract

Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review

Kotze

Underwood

Damião

et al. 2020

Clinical Gastroenterology and Hepatology

143

View full text Add to dashboard Cite

BACKGROUND & AIMS:The incidence of inflammatory bowel diseases (IBD) is increasing in Latin America. We performed a systematic review to identify clinical and epidemiologic features of IBD in Latin America (including Mexico, Central America, and South America) and the Caribbean. METHODS:We searched MEDLINE, EMBASE, and SciELO databases for clinical or epidemiologic studies of Crohn's disease (CD) or ulcerative colitis (UC) from Latin American and Caribbean countries and territories that reported incidence, prevalence, ratio of UC:CD, IBD phenotype, and treatment, through September 12, 2018. Data were extracted from 61 articles for analysis. RESULTS:The incidence and prevalence of IBD have been steadily increasing in Latin America and the Caribbean. The incidence of CD in Brazil increased from 0.08 per 100,000 person-years in 1988 to 0.68 per 100,000 person-years in 1991-1995 to 5.5 per 100,000 person-years in 2015. The highest reported prevalence of IBD was in Argentina, in 2007, at 15 and 82 per 100,000 personyears for CD and UC, respectively. The ratio of UC:CD exceeded 1 in all regions throughout Latin America and the Caribbean with the exception of Brazil. Treatment with tumor necrosis factor antagonists increased steadily for patients with CD (43.4% of all patients in Brazil were treated in 2014) but less so for patients with UC (4.5% of all patients were treated in 2014). Surgery for IBD decreased with time. In Chile, surgeries were performed on 57.0% of patients with CD and 18.0% of patients with UC during the period of 1990-2002; these values decreased to 38.0% and 5.0%, respectively, during the period of 2012-2015. In Peru, 6.9% of patients with UC received colectomies in the period of 2001-2003 and 6.2% in 2004-2014. CONCLUSIONS:In a systematic review, we found the incidence of IBD to be increasing throughout Latin America and the Caribbean. Population-based epidemiology studies are needed to evaluate the increase in IBD in these regions, which differ from other global regions in climate, culture, demographics, diet, healthcare delivery and infrastructure, and socioeconomic status.

show abstract

P688 Demographic, clinical, and therapeutic characteristics of a cohort of 238 patients with ulcerative colitis from two medical centres from Uruguay

Cited by 5 publications

References 0 publications

Review of the epidemiology and burden of ulcerative colitis in Latin America

Review of the epidemiology and burden of ulcerative colitis in Latin America

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review

Contact Info

Product

Resources

About