P6433Coronary artery ectasia is a strong predictor of acute atherotrombotic events after an acute coronary syndrome

Peláez, Juan Antonio Franco; Reyes, Roberto Martín; Lázaro, A. M.; Navarro, A.; O, Gonzalez; Ventura, Jose Luis Martin; Colio, L. Blanco; Casaus, María Luisa González; González, Ignacio Hernández; Carda, Rocío; Mariscal, María Luisa Martín; Egido, Jesús; Tuñón, José

doi:10.1093/eurheartj/ehy566.p6433

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“…Одним из представителей большого семейства хемотактических цитокинов является моноцитарный хемоаттрактантный белок 1 (MCP-1 -Monocyte Chemoat tractant Protein 1). Экспериментальные данные свидетельствуют о том, что MCP-1 активно экспрессируется в АСБ [12]. При инфаркте мио карда (ИМ) MCP-1 способствует привлечению мононуклеарных клеток, изменяя при этом фенотип моноцитов и лимфоцитов.…”

Section: Introductionunclassified

Age-associated level of myocardial fibrosis markers and chemokines in patients with acute coronary syndrome

Осипова

Головин

Белоусова

et al. 2021

Cardiovasc Ther Prev

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Aim. To study age-related specifics of the concentration of fibrosis markers and monocyte chemotactic protein-1 (MCP-1) in patients with ST-segment elevation acute coronary syndrome (STE-ACS).Material and methods. A total of 140 STE-ACS patients were examined. Depending on the age, participants were divided into following groups: middle age — 42 patients, elderly — 50 patients, senile — 48 patients. The control group (CG) consisted of 20 people without cardiovascular disease. The level of matrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), MCP-1 was determined by enzyme immunoassay. Statistical processing was carried out using the MATLAB 2020software.Results. It was found that in STE-ACS patients, the MMP-9 level in middle-aged patients is 2,9 times higher than in the CG (p<0,001), elderly — 4,1 times (p<0,001), senile — 6 times (p<0,001). A strong direct relationship was found between age and MMP-9 level (r=0,86088, p<0,001). The TIMP-1 level was higher in all patients (p<0,05) compared with CG. A strong direct relationship was found between levels of MMP-9 and TIMP-1 (r=0,7801; p<0,01). The MMP-9/TIMP-1 ratio was higher in the group of middle-aged people by 85,7% (p<0,05), elderly — 1,2 times (p<0,001), senile — 2,3 times (p<0,001) compared to CG. MCP-1 was elevated in all age groups (p <0,001). A direct correlation was found between levels of MCP-1 and MMP-9 (r=0,726, p<0,001).Conclusion. In STE-ACS patients, an age-associated increase in concentrations of MMP-9 and MMP-9/TIMP-1 ratio was found in comparison with CG, which indicates the predominance of intercellular matrix degradation marker in patients with ACS. At the same time, MMP-9 increase is possibly induced by MCP-1.

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Section: Introductionunclassified