P630 Epidemiological and phenotypic characteristics of IBD patients in Romania – results of a nationwide hospital-based registry

Gheorghe, Cristian; Dimitriu, Andreea; Iacob, R.; Cojocaru, M; Lupei, Cristina; Vadan, Roxana; Dobru, Daniela; Trifan, Anca; Tanţău, Marcel; Goldiş, Adrian; Constantinescu, Georgiana; Gologan, S.; Mateescu, Bogdan; Gheonea, Dan-Ionuţ; Gheorghe, L.; Diculescu, Mircea

doi:10.1016/s1873-9946(14)60750-9

Cited by 1 publication

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“…In accordance with the latest study made in Dobrogea [7], more than half of the CD patients (60.6%) had a uniformly age distribution between 21-50 years and there were no statistical differences between male and female. These findings are in contrast with literature that indicates a high prevalence of CD in young females [8,10].…”

Section: Discussioncontrasting

confidence: 99%

“…Disease behavior In concordance with previous studies [7,8], inflammatory phenotype B1 was predominant, followed by stenotic B2 and penetrant B3 and perianal disease was present in a small percentage.…”

Section: Discussionsupporting

confidence: 91%

“…Disease location Almost half of patients had ileo-colonic L3 involvement, similar with other studies like ESCAPE in Serbia [12] or Hungary [13], but in contradictory with the results from IBSEN Study [14] or national studies where colonic involvement L2 [7,8,9] or ileal involvement L1 [10] were predominant. We don't have information about the upper digestive tract involvement because we don't routinely perform upper GI endoscopy in our patients unless they have symptoms.…”

Section: Discussionsupporting

confidence: 62%

“…A similar local study conducted years ago showed the same results [7]. In contrast, other studies [8,9,10] published the predominance of UC in different regions of Romania and a south-west to north-east phenotypic gradient. Recent information from our National Database IBD Prospect [10] indicates that UC is predominant in our country.…”

Section: Discussionsupporting

confidence: 56%

“…We suppose that the predominance of CD in Dobrogea can be due to environmental factors, diet or ethnics, but additional epidemiological studies to better define the association with environmental factors and risk factors for CD or UC in our region are needed. [8,10] CROHN'S DISEASE Gender and age distribution The mean age was 44 years in both CD and UC and is higher than data available from other national studies [10] or from Europe and USA where the incidence peak is under 35 years of age [11]. In accordance with the latest study made in Dobrogea [7], more than half of the CD patients (60.6%) had a uniformly age distribution between 21-50 years and there were no statistical differences between male and female.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Bowel Diseases: focus on epidemiology

Tecchio

Achim

Alexandrescu

et al. 2017

ARS Medica Tomitana

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The worldwide incidence and prevalence of Inflammatory Bowel Diseases (IBD) continues to increase, recent studies showing a future global spread of Inflammatory Bowel Diseases. Epidemiological data coming for Romania are scarce. The aim is to describe epidemiological features of Inflammatory Bowel Diseases in an adult population in the South-East side of Romania. The retrospective and descriptive study included 128 patients: group 1=Crohn’s Disease (CD) (79), group 2=Ulcerative Colitis (UC) (46) and group 3=Unclassified Colitis (Unclassified C) (3). We calculated the prevalence of Inflammatory Bowel Diseases in Constanţa in 2016. The phenotypic distribution was: 62% with Crohn’s Disease, 36% with Ulcerative Colitis and 3 patients with Unclassified Colitis. Crohn’s Disease: The prevalence was 0.11/100000 inhabitants. 51% were female and 49% were male. The age distribution showed a uniform model of the frequency of Crohn’s Disease in patients aged between 21 and 50 years. According to Montreal Classification, ileo-colonic involvement L3 was the most frequent in 47% and 60% patients presented inflammatory phenotype B1. 44% had intestinal complications. 9% had extraintestinal complications. 16.4% required surgical interventions. Ulcerative Colitis: The prevalence was 0.06/100000 inhabitants. We noticed a slight male predominance: 57% were male and 43% female. The age distribution showed a bimodal peak of incidence in patients aged between 21-30 years and 41-50 years. The most common disease extension was left colitis E2 in 47% cases. One patient had an enterovesical fistula. Extraintestinal complications were not reported in this group. No patient required surgical intervention. Unclassified Colitis: 3 male patients with ages between 31-50 years were diagnosed with Unclassified Colitis. Complications or need for surgery were not reported in this group. We noticed the predominance of Crohn’s Disease in our region while in other parts of Romania Ulcerative Colitis is predominant. We suppose that the predominance of Crohn’s Disease in Dobrogea can be due to environmental factors, diet or ethnics, but additional epidemiological studies to define better the association with environmental factors and risk factors for Crohn Disease or Ulcerative Colitis in our region are needed.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%